Clinical significance of determining the lipocalin associated with neutrophil gelatinase urine levels in patients with st-elevation myocardial infarction and acute ischemic kidney injury
https://doi.org/10.51922/2616-633X.2021.5.2.1292
Abstract
The aim of the study was to assess the clinical significance of determining the level of lipocalin associated with neutrophil gelatinase in urine (uNGAL) at the time of hospital admission in patients with acute ST-elevation myocardial infarction (STEMI) and acute ischemic kidney injury. Conclusion. Acute ischemic kidney injury is a frequent complication of STEMI. Based on the findings of the study uNGAL can be applied as an early marker of acute ischemic kidney injury and a predictor of post-discharge CKD in patients with MI.
About the Authors
E. BrankovskayaBelarus
E. Grigorenko
Belarus
T. Statkevich
Belarus
L. Kartun
Belarus
E. Hodosovskaya
Belarus
N. Mitkovskaya
Belarus
References
1. Singh S., Kanwar A., Sundaragiri P. R., Cheungpasitporn W., Truesdell A. G., Rab S. T., Singh M., Vallabhajosyula S. Acute Kidney Injury in Cardiogenic Shock: An Updated Narrative Review. J. Cardiovasc Dev Dis, 2021, vol. 8, no. 8, pp. 88. https://doi.org/10.3390/jcdd8080088.
2. El-Ahmadi A., Abassi M. S., Andersson H. B., Engstrøm T., Clemmensen P., Helqvist S., Jørgensen E., Kelbæk H., Pedersen F., Saunamäki K., Lønborg J., Holmvang L. Acute kidney injury - A frequent and serious complication after primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction. PLoS One, 2019, vol. 14, no. 12, pp. e0226625. doi:10.1371/journal.pone.0226625.
3. Ong L. T. Evidence based review of management of cardiorenal syndrome type 1. World J Methodol, 2021, vol. 11, no. 4, pp. 187-198. doi: 10.5662/wjm.v11.i4.187.
4. Brankovskaya E. Yu., Kartun L. V., Hodosovskaya E. V., Mit’kovskaya N. P. Krupnoochagovyj infarkt miokarda i ostroe ishemicheskoe povrezhdenie pochek [ST-elevation myocardial infarction and acute ischemic kidney injury]. Neotlozhnaya kardiologiya i kardioovaskulyarnye riski, 2020, vol. 4, no. 2, pp. 979-985. (in Russian).
5. Kellum J. A., Lameire N. KDIGO AKI Guideline Work Group. Diagnosis, evaluation, and management of acute kidney injury: a KDIGO summary (Part 1). Crit Care, 2013, vol. 17, no. 1, pp. 204.
6. Dong-Jin Oh A long journey for acute kidney injury biomarkers. Renal Failure, 2020, vol. 42, no. 1, pp. 154-165. doi: 10.1080/0886022X.2020.1721300.
7. Liu X., Guan Y., Xu S., Li Q., Sun Y., Han R., Jiang C. Early Predictors of Acute Kidney Injury: A Narrative Review. Kidney Blood Press Res, 2016, vol. 41, no. 5, pp. 680-700. doi: 10.1159/000447937.
8. Haase M., Bellomo R., Devarajan P., Schlattmann P., Haase-Fielitz A., Group NM-aI. Accuracy of neutrophil gelatinase-associated lipocalin (NGAL) in diagnosis and prognosis in acute kidney injury: A systematic review and meta-analysis. Am J Kidney Dis, 2009, vol. 54, no. 6, pp. 1012-1024.
9. Hirsch R., Dent C., Pfriem H., Allen J., Beekman R.H., Ma Q., Dastrala S., Bennett M., Mitsnefes M., Devarajan P. NGAL Is an Early Predictive Biomarker of Contrast-Induced Nephropathy in Children. Pediatr Nephrol Berl Ger, 2007, vol. 22, no. 12, pp. 2089-2095.
10. Kim J. D., Chee H. K., Shin J. K., Kim J. S., Lee S. A., Kim Y. H., Lee W. S., Kim H. Y. Novel Early Predictor of Acute Kidney Injury after Open Heart Surgery under Cadiopulmonary Bypass Using Plasma Neutrophil Gelatinase-Associated Lipocalin. Korean J Thorac Cardiovasc Surg, 2014, vol. 47, no. 3, pp. 240-248.
11. Mishra J., Ma Q., Prada A., Mitsnefes M., Zahedi K., Yang J., Barasch J., Devarajan P. Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury. J Am Soc Nephrol, 2003, vol. 14, no. 10, pp. 2534-2543. doi: 10.1097/01.asn.0000088027.54400.
12. Kellum J. A., Romagnani P., Ashuntantang G., Ronco C., Zarbock A., Anders H. J. Acute kidney injury. Nat Rev Dis Primers, 2021, vol. 7, no. 1, pp. 52. doi: 10.1038/s41572-021-00284-z.
13. Fortrie G., de Geus H. R. H., Betjes M. G. H. The aftermath of acute kidney injury: a narrative review of long-term mortality and renal function. Crit Care, 2019, vol. 23, no. 1, pp. 24. doi.org/10.1186/s13054-019-2314-z.
14. Hsu R. K., Hsu C. Y. The Role of Acute Kidney Injury in Chronic Kidney Disease. Semin Nephrol, 2016, vol. 36, no. 4, pp. 283-292. doi:10.1016/j.semnephrol.2016.05.005.
15. Jamme M., Legrand M., Geri G. Outcome of acute kidney injury: how to make a difference? Ann. Intensive Care, 2021, vol. 11, no. 1, pp. 60. doi.org/10.1186/s13613-021-00849-x.
16. Sharipova Kh. Yo., Gulov M. K., Ismailov S. S., Tagoev S. Kh., Sokhibov R. G. Terminalnaya chronicheskaya pochechnaya nedostatochnost: ocenka riska, etapi terapii I cardialnie problem [Terminal chronic renal failure: risk assessment, stages of therapy and cardiac problem]. Vestnik Аvitsenny, 2013, no. 2, pp.153-159 (in Russian).
Review
For citations:
Brankovskaya E., Grigorenko E., Statkevich T., Kartun L., Hodosovskaya E., Mitkovskaya N. Clinical significance of determining the lipocalin associated with neutrophil gelatinase urine levels in patients with st-elevation myocardial infarction and acute ischemic kidney injury. Emergency Cardiology and Cardiovascular Risks journal. 2021;5(2):1292–1297. (In Russ.) https://doi.org/10.51922/2616-633X.2021.5.2.1292









