emcardioНеотложная кардиология и кардиоваскулярные рискиEmergency Cardiology and Cardiovascular Risks journal2616-633XБелорусский государственный медицинский университет10.51922/2616-633X.2021.5.2.1292emcardio-168Research ArticleОригинальные научные публикацииOriginal Scientific ResearchКлиническое значение определения уровня липокалина, ассоциированного с желатиназой нейтрофилов в моче у пациентов с крупноочаговым инфарктом миокарда и острым ишемическим повреждением почекClinical significance of determining the lipocalin associated with neutrophil gelatinase urine levels in patients with st-elevation myocardial infarction and acute ischemic kidney injuryБранковскаяЕ. Ю.BrankovskayaE.ГригоренкоЕ. А.GrigorenkoE.СтаткевичТ. В.StatkevichT.КартунЛ. В.KartunL.ХодосовскаяЕ. В.HodosovskayaE.МитьковскаяН. П.MitkovskayaN.Кардиологический центр Первомайского района г. Минска УЗ «8-я городская поликлиника»Pervomaisky District Cardiological CenterУО «Белорусский государственный медицинский университет»Belarusian State Medical UniversityГУ «Республиканский научно-практический центр «Кардиология»Scientific and Practical Center “Cardiology”202124102025521292–1297Copyright © Бранковская Е.Ю., Григоренко Е.А., Статкевич Т.В., Картун Л.В., Ходосовская Е.В., Митьковская Н.П., 20252025Бранковская Е.Ю., Григоренко Е.А., Статкевич Т.В., Картун Л.В., Ходосовская Е.В., Митьковская Н.П.Brankovskaya E., Grigorenko E., Statkevich T., Kartun L., Hodosovskaya E., Mitkovskaya N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://emcardio.bsmu.by/jour/article/view/168

Цель исследования: оценить клиническое значение определения уровня липокалина, ассоциированного с желатиназой нейтрофилов в моче (uNGAL), определенного при поступлении в стационар у пациентов с острым крупноочаговым инфарктом миокарда (ИМ) и острым ишемическим повреждением почек. Заключение. Острое ишемическое повреждение почек является частым осложнением крупноочагового ИМ. В данном исследовании uNGAL зарекомендовал себя перспективным ранним маркером острого ишемического повреждения почек и предиктором развития ХБП в постгоспитальном периоде у пациентов с ИМ.

The aim of the study was to assess the clinical significance of determining the level of lipocalin associated with neutrophil gelatinase in urine (uNGAL) at the time of hospital admission in patients with acute ST-elevation myocardial infarction (STEMI) and acute ischemic kidney injury. Conclusion. Acute ischemic kidney injury is a frequent complication of STEMI. Based on the findings of the study uNGAL can be applied as an early marker of acute ischemic kidney injury and a predictor of post-discharge CKD in patients with MI.

инфаркт миокардаострое повреждение почеклипокалинассоциированный с желатиназой нейтрофиловNGALmyocardial infarctionacute kidney injury. neutrophil gelatinase-associated lipocalinNGALReferencesSingh S., Kanwar A., Sundaragiri P. R., Cheungpasitporn W., Truesdell A. G., Rab S. T., Singh M., Vallabhajosyula S. Acute Kidney Injury in Cardiogenic Shock: An Updated Narrative Review. J. Cardiovasc Dev Dis, 2021, vol. 8, no. 8, pp. 88. https://doi.org/10.3390/jcdd8080088.Singh S., Kanwar A., Sundaragiri P. R., Cheungpasitporn W., Truesdell A. G., Rab S. T., Singh M., Vallabhajosyula S. Acute Kidney Injury in Cardiogenic Shock: An Updated Narrative Review. J. Cardiovasc Dev Dis, 2021, vol. 8, no. 8, pp. 88. https://doi.org/10.3390/jcdd8080088.El-Ahmadi A., Abassi M. S., Andersson H. B., Engstrøm T., Clemmensen P., Helqvist S., Jørgensen E., Kelbæk H., Pedersen F., Saunamäki K., Lønborg J., Holmvang L. Acute kidney injury - A frequent and serious complication after primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction. PLoS One, 2019, vol. 14, no. 12, pp. e0226625. doi:10.1371/journal.pone.0226625.El-Ahmadi A., Abassi M. S., Andersson H. B., Engstrøm T., Clemmensen P., Helqvist S., Jørgensen E., Kelbæk H., Pedersen F., Saunamäki K., Lønborg J., Holmvang L. Acute kidney injury - A frequent and serious complication after primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction. PLoS One, 2019, vol. 14, no. 12, pp. e0226625. doi:10.1371/journal.pone.0226625.Ong L. T. Evidence based review of management of cardiorenal syndrome type 1. World J Methodol, 2021, vol. 11, no. 4, pp. 187-198. doi: 10.5662/wjm.v11.i4.187.Ong L. T. Evidence based review of management of cardiorenal syndrome type 1. World J Methodol, 2021, vol. 11, no. 4, pp. 187-198. doi: 10.5662/wjm.v11.i4.187.Brankovskaya E. Yu., Kartun L. V., Hodosovskaya E. V., Mit’kovskaya N. P. Krupnoochagovyj infarkt miokarda i ostroe ishemicheskoe povrezhdenie pochek [ST-elevation myocardial infarction and acute ischemic kidney injury]. Neotlozhnaya kardiologiya i kardioovaskulyarnye riski, 2020, vol. 4, no. 2, pp. 979-985. (in Russian).Brankovskaya E. Yu., Kartun L. V., Hodosovskaya E. V., Mit’kovskaya N. P. Krupnoochagovyj infarkt miokarda i ostroe ishemicheskoe povrezhdenie pochek [ST-elevation myocardial infarction and acute ischemic kidney injury]. Neotlozhnaya kardiologiya i kardioovaskulyarnye riski, 2020, vol. 4, no. 2, pp. 979-985. (in Russian).Kellum J. A., Lameire N. KDIGO AKI Guideline Work Group. Diagnosis, evaluation, and management of acute kidney injury: a KDIGO summary (Part 1). Crit Care, 2013, vol. 17, no. 1, pp. 204.Kellum J. A., Lameire N. KDIGO AKI Guideline Work Group. Diagnosis, evaluation, and management of acute kidney injury: a KDIGO summary (Part 1). Crit Care, 2013, vol. 17, no. 1, pp. 204.Dong-Jin Oh A long journey for acute kidney injury biomarkers. Renal Failure, 2020, vol. 42, no. 1, pp. 154-165. doi: 10.1080/0886022X.2020.1721300.Dong-Jin Oh A long journey for acute kidney injury biomarkers. Renal Failure, 2020, vol. 42, no. 1, pp. 154-165. doi: 10.1080/0886022X.2020.1721300.Liu X., Guan Y., Xu S., Li Q., Sun Y., Han R., Jiang C. Early Predictors of Acute Kidney Injury: A Narrative Review. Kidney Blood Press Res, 2016, vol. 41, no. 5, pp. 680-700. doi: 10.1159/000447937.Liu X., Guan Y., Xu S., Li Q., Sun Y., Han R., Jiang C. Early Predictors of Acute Kidney Injury: A Narrative Review. Kidney Blood Press Res, 2016, vol. 41, no. 5, pp. 680-700. doi: 10.1159/000447937.Haase M., Bellomo R., Devarajan P., Schlattmann P., Haase-Fielitz A., Group NM-aI. Accuracy of neutrophil gelatinase-associated lipocalin (NGAL) in diagnosis and prognosis in acute kidney injury: A systematic review and meta-analysis. Am J Kidney Dis, 2009, vol. 54, no. 6, pp. 1012-1024.Haase M., Bellomo R., Devarajan P., Schlattmann P., Haase-Fielitz A., Group NM-aI. Accuracy of neutrophil gelatinase-associated lipocalin (NGAL) in diagnosis and prognosis in acute kidney injury: A systematic review and meta-analysis. Am J Kidney Dis, 2009, vol. 54, no. 6, pp. 1012-1024.Hirsch R., Dent C., Pfriem H., Allen J., Beekman R.H., Ma Q., Dastrala S., Bennett M., Mitsnefes M., Devarajan P. NGAL Is an Early Predictive Biomarker of Contrast-Induced Nephropathy in Children. Pediatr Nephrol Berl Ger, 2007, vol. 22, no. 12, pp. 2089-2095.Hirsch R., Dent C., Pfriem H., Allen J., Beekman R.H., Ma Q., Dastrala S., Bennett M., Mitsnefes M., Devarajan P. NGAL Is an Early Predictive Biomarker of Contrast-Induced Nephropathy in Children. Pediatr Nephrol Berl Ger, 2007, vol. 22, no. 12, pp. 2089-2095.Kim J. D., Chee H. K., Shin J. K., Kim J. S., Lee S. A., Kim Y. H., Lee W. S., Kim H. Y. Novel Early Predictor of Acute Kidney Injury after Open Heart Surgery under Cadiopulmonary Bypass Using Plasma Neutrophil Gelatinase-Associated Lipocalin. Korean J Thorac Cardiovasc Surg, 2014, vol. 47, no. 3, pp. 240-248.Kim J. D., Chee H. K., Shin J. K., Kim J. S., Lee S. A., Kim Y. H., Lee W. S., Kim H. Y. Novel Early Predictor of Acute Kidney Injury after Open Heart Surgery under Cadiopulmonary Bypass Using Plasma Neutrophil Gelatinase-Associated Lipocalin. Korean J Thorac Cardiovasc Surg, 2014, vol. 47, no. 3, pp. 240-248.Mishra J., Ma Q., Prada A., Mitsnefes M., Zahedi K., Yang J., Barasch J., Devarajan P. Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury. J Am Soc Nephrol, 2003, vol. 14, no. 10, pp. 2534-2543. doi: 10.1097/01.asn.0000088027.54400.Mishra J., Ma Q., Prada A., Mitsnefes M., Zahedi K., Yang J., Barasch J., Devarajan P. Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury. J Am Soc Nephrol, 2003, vol. 14, no. 10, pp. 2534-2543. doi: 10.1097/01.asn.0000088027.54400.Kellum J. A., Romagnani P., Ashuntantang G., Ronco C., Zarbock A., Anders H. J. Acute kidney injury. Nat Rev Dis Primers, 2021, vol. 7, no. 1, pp. 52. doi: 10.1038/s41572-021-00284-z.Kellum J. A., Romagnani P., Ashuntantang G., Ronco C., Zarbock A., Anders H. J. Acute kidney injury. Nat Rev Dis Primers, 2021, vol. 7, no. 1, pp. 52. doi: 10.1038/s41572-021-00284-z.Fortrie G., de Geus H. R. H., Betjes M. G. H. The aftermath of acute kidney injury: a narrative review of long-term mortality and renal function. Crit Care, 2019, vol. 23, no. 1, pp. 24. doi.org/10.1186/s13054-019-2314-z.Fortrie G., de Geus H. R. H., Betjes M. G. H. The aftermath of acute kidney injury: a narrative review of long-term mortality and renal function. Crit Care, 2019, vol. 23, no. 1, pp. 24. doi.org/10.1186/s13054-019-2314-z.Hsu R. K., Hsu C. Y. The Role of Acute Kidney Injury in Chronic Kidney Disease. Semin Nephrol, 2016, vol. 36, no. 4, pp. 283-292. doi:10.1016/j.semnephrol.2016.05.005.Hsu R. K., Hsu C. Y. The Role of Acute Kidney Injury in Chronic Kidney Disease. Semin Nephrol, 2016, vol. 36, no. 4, pp. 283-292. doi:10.1016/j.semnephrol.2016.05.005.Jamme M., Legrand M., Geri G. Outcome of acute kidney injury: how to make a difference? Ann. Intensive Care, 2021, vol. 11, no. 1, pp. 60. doi.org/10.1186/s13613-021-00849-x.Jamme M., Legrand M., Geri G. Outcome of acute kidney injury: how to make a difference? Ann. Intensive Care, 2021, vol. 11, no. 1, pp. 60. doi.org/10.1186/s13613-021-00849-x.Sharipova Kh. Yo., Gulov M. K., Ismailov S. S., Tagoev S. Kh., Sokhibov R. G. Terminalnaya chronicheskaya pochechnaya nedostatochnost: ocenka riska, etapi terapii I cardialnie problem [Terminal chronic renal failure: risk assessment, stages of therapy and cardiac problem]. Vestnik Аvitsenny, 2013, no. 2, pp.153-159 (in Russian).Sharipova Kh. Yo., Gulov M. K., Ismailov S. S., Tagoev S. Kh., Sokhibov R. G. Terminalnaya chronicheskaya pochechnaya nedostatochnost: ocenka riska, etapi terapii I cardialnie problem [Terminal chronic renal failure: risk assessment, stages of therapy and cardiac problem]. Vestnik Аvitsenny, 2013, no. 2, pp.153-159 (in Russian).

The authors declare that there are no conflicts of interest present.