Biochemical predictors of acute heart failure development in the early postoperative period after coronary artery bypass surgery and valve repair in individuals with ischemic heart disease and preserved ejection fraction
Abstract
Aim. To determine the prognostic significance of cardiac biomarkers in the development of acute heart failure in operated patients with ischemic heart disease and preserved left ventricular ejection fraction.
Methods. 92 patients with IHD (with preserved EF) and forthcoming coronary artery bypass surgery (CABS) were examined. Of them 50 patients (54 %) underwent CABG and 42 patients (46 %) - CABS combined with mitral and/or tricuspid valve repair. Initial examination consisted of echocardiography with tissue Doppler mapping, coronary angio¬graphy, MRI - cardiac examination, as well as identifying the levels of cystatin C, natriuretic peptide (NT-pro-BNP), galectin-3, stimulating sST-2 and high-sensitive troponin.
Results. While determining the threshold values of acute heart failure predictors, brain natriuretic peptide and sST 2 proved to be independent predictors. When the preoperative threshold level of sST2 is exceeded > 45 ng/ml, the odds ratio (OR) of postoperative period complicated course is 5.345 (95 % CI 3.6-9.78, p = 0.01), for the NT-pro- BNP > 500 pg/ml - 6.578 (95 % CI 4.3-9.96, p = 0.02).
Conclusion. Cardiac biomarkers have demonstrated a high level of informative value for acute heart failure prognosis in operated patients with ischemic heart disease and preserved left ventricular ejection fraction.
About the Authors
N. A. Shibeko
Государственное учреждение «Республиканский научно-практический центр «Кардиология»
Belarus
Belarus
L. G. Gelis
Государственное учреждение «Республиканский научно-практический центр «Кардиология»
Belarus
Belarus
T. V. Rusak
Государственное учреждение «Республиканский научно-практический центр «Кардиология»
Belarus
Belarus
V. V. Shumovetc
Государственное учреждение «Республиканский научно-практический центр «Кардиология»
Belarus
Belarus
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For citations:
Shibeko N.A., Gelis L.G., Rusak T.V., Shumovetc V.V. Biochemical predictors of acute heart failure development in the early postoperative period after coronary artery bypass surgery and valve repair in individuals with ischemic heart disease and preserved ejection fraction. Emergency Cardiology and Cardiovascular Risks journal. 2018;2(1):237-243. (In Russ.)
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