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Influence of metal complex derivatives of alkenyl imidazole on the survival of mice under conditions of hypobaric hypoxia

Abstract

To study the influence of five metal complex compounds, derivatives of alkenyl imidazole, and two pharmaceutical drug products with the antihypoxic properties (hypoxen, mexidol) on the lifespan of mice under conditions of acute hypobaric hypoxia (AHBH).

About the Authors

E. V. Udovenko
Bryansk State Technical University
Russian Federation


O. F. Kraetskaya
Belarusian State Medical University
Belarus


S. N. Borisevitch
Belarusian State Medical University
Belarus


O. N. Ryneiskaya
Belarusian State Medical University
Belarus


References

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2. Shachmardanova S.A. Farmakologicheskaya korrekziya gipoksicheskich sostoyaniy metallokompleksnymi proizvonnymi N-alkenil-, N-propargilimidazolov i 3-gidroksipiridina [Pharmacological correction of hypoxic states by metal complex pro-vertebral N-alkenyl, N-propargylimidazoles and 3-hydroxypyridine] : Avtoref. dis. dokt. boil. nauk: 14.03.06. Moskva, 2018, 47 s. (in Russian).

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5. Voronina T.A., Smirnov L.D., Dyumaev K.M. Vozmozhnosti primeneniya meksidola veksperimental’nych usloviyach [The possibility of using Mexidol in experimental conditions]. Chelovek i lekarstvo : tez. dokl. VII Ross. naz. kongressa. Moskva, 2000, s. 483. (in Russian).

6. Tregub P.P., Kulikov V.P., Bespalov A.G., Vvedensky A.J., Osipov I.S. Neyroprotektivnaya effektivnost’ trenirovok s izolirovannym i sochetannym vozdeystviem gipoksiey i giperkapniey v eksperimente. Byulleten’ eksperimental’noy biologii i mediziny [Neuroprotective effects of individual or combined exposure to hypoxia and hypercapnia in the experiment]. Bul Experimental Biology Medicine, 2013, vol. 155, no. 3, pp. 302–304. (in Russian).

7. Miroshnichenko I.I., Smirnov L.D., Yasnezov V.V. [et all.] Neyrochimicheskie aspekty deystviya meksidola [Neurochemical aspects of the action of Mexidol]. Chelovek i le-karstvo : tez. dokl. VII Ross. naz. kongr. Moskva, 2000, s. 661. (in Russian).

8. Lukyanova L.D. Sovremennye problemy adaptazii k gipoksii. Signal’nye mechanizmyi ich rol’ v sistemnoy regulyazii [Current issues of adaptation to hypoxia. Signal mechanisms and their role in system regulation]. Patologicheskaya fiziologiya i eksperimental’naya terapiya, 2011, no. 1, pp. 3–19. (in Russian).

9. Luk’yanova L.D. Metodicheskie rekomendazii po eksperimental’nomu izucheniyu preparatov, predlagaemych dlya klinicheskogo izucheniya v kachestve antigipoksicheskich sredstv [Guidelines for the experimental study of drugs proposed for clinical study as antihypoxic drugs]. Moskva, 1990, 18 s. (in Russian).


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For citations:


Udovenko E.V., Kraetskaya O.F., Borisevitch S.N., Ryneiskaya O.N. Influence of metal complex derivatives of alkenyl imidazole on the survival of mice under conditions of hypobaric hypoxia. Emergency Cardiology and Cardiovascular Risks journal. 2019;3(1):563–567. (In Russ.)

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ISSN 2616-633X (Print)