emcardioНеотложная кардиология и кардиоваскулярные рискиEmergency Cardiology and Cardiovascular Risks journal2616-633XБелорусский государственный медицинский университет10.51922/2616-633X.2022.6.2.1700emcardio-90Research ArticleОбзоры и лекцииReviews and lecturesМенопаузальная гормональная терапия и риски венозных тромбоэмболических осложнений: современный аспект проблемыMenopausal hormone therapy and the risk of venous thromboembolic complications: a modern aspect of the problemЗахаркоА. Ю.ZaharkoА.

г. Гомель

Gomel

ПодгорнаяА. С.PodgornayA.

г. Гомель

Gomel

МурашкоО. В.MurashkoO.

г. Гомель

Gomel

ГУ «Республиканский научно-практический центр радиационной медицины и экологии человека»,Republican Scientific and Practical Center for Radiation Medicine and Human Ecology2022230620256217001706Copyright © Захарко А.Ю., Подгорная А.С., Мурашко О.В., 20252025Захарко А.Ю., Подгорная А.С., Мурашко О.В.Zaharko А., Podgornay A., Murashko O.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://emcardio.bsmu.by/jour/article/view/90

Возрастные аспекты женского здоровья в фокусе внимания кардиологов, гинекологов, эндокринологов уже на протяжении многих лет. Достаточно хорошо изучены физиологические особенности течения пери- и постменопаузального периодов, возможные последствия дефицита эстрогенов. В течение почти 20 лет ведутся споры о соотношении пользы и риска менопаузальной гормональной терапии. Доказательства ее протективного влияния в отношении заболеваний, ассоциированных с возрастом, не оставляют сомнений: профилактическое воздействие в отношении развития остеопороза, сердечно-сосудистых заболеваний, когнитивных расстройств и улучшения качества жизни в целом. В статье приведены современные данные о связи менопаузальной гормональной терапии с венозными тромбоэмболическими осложнениями в зависимости от вида эстрогенного и прогестагенного компонентов, дозы, режима и способов применения. Рассмотрена целесообразность и безопасность менопаузальной гормональной терапии в условиях пандемии коронавирусной инфекции COVID-19. Опасения возможного потенцирования риска тромбоэмболических осложнений в случае заражения COVID-19 на фоне приема менопаузальной гормональной терапии не были доказаны в клинической практике. Представлены данные новейших публикаций, свидетельствующие о вероятном положительном влиянии женских половых гормонов на течение SARS-CoV-2, и рекомендации ведущих международных сообществ по менопаузе относительно допустимости менопаузальной гормональной терапии в условиях пандемии и ограниченной возможности консультирования пациенток.

Age-related aspects of women’s health have been in the focus of attention of cardiologists, gynecologists, and endocrinologists for many years. The physiological features of the course of the peri- and postmenopausal periods and the possible consequences of estrogen deficiency are already well-studied. For nearly 20 years, there has been a debate about the benefit-risk ratio of menopausal hormone therapy. The evidence for its protective effect on age-related cases is overwhelming: prevention of osteoporosis development, cardiovascular diseases, cognitive decline, and improvement of the overall quality of life. The article presents current data on the association of menopausal hormone therapy with venous thromboembolic complications, depending on the type of estrogen and progestogen components, dose, regimen and methods of application. The feasibility and safety of menopausal hormone therapy in the context of the COVID-19 coronavirus pandemic is considered. The probability of increased risk of thromboembolic complications in case of COVID-19 infection during menopausal hormone therapy has not been proven in clinical practice. The data from the latest publications are presented, indicating the likely positive effect of female sex hormones on the course of SARS-CoV-2 and the recommendations of the leading international communities on menopause measurement regarding the admissibility of menopausal hormone therapy during the pandemic and limited ability to counsel patients.

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The authors declare that there are no conflicts of interest present.