emcardioНеотложная кардиология и кардиоваскулярные рискиEmergency Cardiology and Cardiovascular Risks journal2616-633XБелорусский государственный медицинский университет10.51922/2616-633X.2022.6.2.1714emcardio-88Research ArticleОбзоры и лекцииReviews and lecturesСовременные тенденции применения гиполипидемических препаратов для лечения пациентов с атеросклерозомModern trends in the use of lipid-lowering drugs for the treatment of patients with atherosclerosisКордзахияГ. Э.KordzakhiaG. E.

г. Минск

Minsk

СпиридоновС. В.SpiridonovS. V.

г. Минск

Minsk

КлимчукИ. П.KlimchukI. P.

г. Минск

Minsk

ХалькинИ. А.KhalkinI. A.

г. Минск

Minsk

ДровилоЕ. М.DroviloE. M.

г. Минск

Minsk

Республиканский научно-практический центр «Кардиология»; 4-я городская клиническая больница имени Н.Е. СавченкоScientific and Practical Centre of Cardiology; 4<sup>th</sup>th City Clinical Hospital named after M. SaŭčankaРеспубликанский научно-практический центр «Кардиология»Scientific and Practical Centre of Cardiology; 4<sup>th</sup>th City Clinical Hospital named after M. Saŭčanka4-я городская клиническая больница имени Н.Е. Савченко4<sup>th</sup>th City Clinical Hospital named after M. SaŭčankaРеспубликанский научно-практический центр «Кардиология»Scientific and Practical Centre of Cardiology2022230620256217141722Copyright &#x00A9; Кордзахия Г.Э., Спиридонов С.В., Климчук И.П., Халькин И.А., Дровило Е.М., 20252025Кордзахия Г.Э., Спиридонов С.В., Климчук И.П., Халькин И.А., Дровило Е.М.Kordzakhia G.E., Spiridonov S.V., Klimchuk I.P., Khalkin I.A., Drovilo E.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://emcardio.bsmu.by/jour/article/view/88

Создание гиполипидемических препаратов стало одним из самых крупных достижений медицины за последние 100 лет. В настоящее время сердечно-сосудистые заболевания, вызванные атеросклерозом, являются основной причиной смерти в большинстве стран. Атеросклероз – это сложный патологический процесс, включающий в себя отложение липидов и активацию иммунных и воспалительных реакций в стенке артерии, которые в конечном итоге приводят к сердечно-сосудистым заболеваниям в результате частичного или полного перекрытия просвета сосуда. На сегодняшний день одной из основных стратегий в лечении сердечно-сосудистых заболеваний, вызванных атеросклерозом, является липид-модифицирующая терапия. Хотя клинические исследования средств, снижающих уровень холестерина липопротеинов низкой плотности (ХС-ЛПНП) (статины, эзетимиб, ингибиторы PCSK9 [субтилизин/кексин 9] пропротеинконвертазы), достоверно указывают на снижение частоты сердечно-сосудистых заболеваний, у значительной части пациентов по-прежнему сохраняется относительно высокий риск кардиоваскулярных событий.

The creation of lipid-lowering drugs has become one of the greatest achievements of medicine over the past 100 years. Nowadays, cardiovascular diseases caused by atherosclerosis are the leading cause of death in most countries. Atherosclerosis is a complex process involving the deposition of lipids and the activation of immune and inflammatory responses that ultimately lead to cardiovascular disease as a result of arterial occlusion. Currently, the main strategy for the treatment of cardiovascular diseases caused by atherosclerosis is lipid-modifying therapy. Although clinical trials of agents that lower low-density lipoprotein cholesterol (LDL-C) (statins, ezetimibe, PCSK9 [subtilisin/kexin 9] proprotein convertase inhibitors) reliably indicate a decrease in cardiovascular events, a relatively high risk of cardiovascular events persists in a significant proportion of patients despite such treatment.

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The authors declare that there are no conflicts of interest present.