<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">emcardio</journal-id><journal-title-group><journal-title xml:lang="ru">Неотложная кардиология и кардиоваскулярные риски</journal-title><trans-title-group xml:lang="en"><trans-title>Emergency Cardiology and Cardiovascular Risks journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2616-633X</issn><publisher><publisher-name>Белорусский государственный медицинский университет</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.51922/2616-633X.2022.6.2.1730</article-id><article-id custom-type="elpub" pub-id-type="custom">emcardio-86</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Обзоры и лекции</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Reviews and lectures</subject></subj-group></article-categories><title-group><article-title>Амбулаторные технологии в лечении варикозной болезни нижних конечностей</article-title><trans-title-group xml:lang="en"><trans-title>Outpatient treatment strategies for lower extremity varicose vein disease</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хрыщанович</surname><given-names>В. Я.</given-names></name><name name-style="western" xml:lang="en"><surname>Khryschanovich</surname><given-names>V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>г. Минск</p></bio><bio xml:lang="en"><p>Minsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Роговой</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Rogovoy</surname><given-names>N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>г. Минск</p></bio><bio xml:lang="en"><p>Minsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Климчук</surname><given-names>И. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Klimchuk</surname><given-names>I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>г. Минск</p></bio><bio xml:lang="en"><p>Minsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кресс</surname><given-names>Д. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kress</surname><given-names>D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>г. Минск</p></bio><bio xml:lang="en"><p>Minsk</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кордзахия</surname><given-names>Г. Э.</given-names></name><name name-style="western" xml:lang="en"><surname>Kordzakhia</surname><given-names>G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>г. Минск</p></bio><bio xml:lang="en"><p>Minsk</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Белорусский государственный медицинский университет; 4-я городская клиническая больница им. Н.Е. Савченко</institution></aff><aff xml:lang="en"><institution>Belarusian State Medical University; 4&lt;sup&gt;th&lt;/sup&gt; City Clinical Hospital named after M. Saŭčanka</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>4-я городская клиническая больница им. Н.Е. Савченко</institution></aff><aff xml:lang="en"><institution>4&lt;sup&gt;th&lt;/sup&gt; City Clinical Hospital named after M. Saŭčanka</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>23</day><month>06</month><year>2025</year></pub-date><volume>6</volume><issue>2</issue><fpage>1730</fpage><lpage>1736</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Хрыщанович В.Я., Роговой Н.А., Климчук И.П., Кресс Д.В., Кордзахия Г.Э., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Хрыщанович В.Я., Роговой Н.А., Климчук И.П., Кресс Д.В., Кордзахия Г.Э.</copyright-holder><copyright-holder xml:lang="en">Khryschanovich V., Rogovoy N., Klimchuk I., Kress D., Kordzakhia G.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://emcardio.bsmu.by/jour/article/view/86">https://emcardio.bsmu.by/jour/article/view/86</self-uri><abstract><p>По данным Всемирной организации здравоохранения варикозной болезнью нижних конечностей (ВБ) страдает каждый третий взрослый человек планеты. В Республике Беларусь насчитывается более 2 миллионов человек с варикозным расширением поверхностных вен нижних конечностей, из них около 400 000 – в г. Минске. Трофические нарушения наблюдаются у 2% пациентов от общего количества населения. По данным исследования RELIЕF (Reflux assEssment and quality of life improvement with micronized Flavonoids in chronic venous insufficiency), которое проводилось с марта 1997 г. по декабрь 1998 г. в 23 странах с участием более 10 000 пациентов с хронической венозной недостаточностью (ХВН), 78% обследованных с симптомами ХВН не получали лечения. На сегодняш- ний день арсенал хирургических методов лечения ВБ отличается большим разнообразием. В настоящее время в развитых странах отмечается тенденция к росту малоинвазивных вмешательств в лечении ВБ, выполняемых амбулаторно. Среди предложенных видов инвазивных методов лечения наибольшее распространение получили эндовенозная лазерная коагуляция, склеротерапия, эндовенозная механо-химическая и радиочастотная облитерация.</p></abstract><trans-abstract xml:lang="en"><p>According to the World Health Organization, every third adult on the planet suffers from varicose vein disease of the lower extremities (VVD). In the Republic of Belarus there are more than 2 million people with VVD of the superficial veins of the lower extremities, of which about 400,000 reside in Minsk. Trophic disorders are observed in 2% of the total population. According to the RELIEF study (Reflux assurance and quality of life improvement with micronized Flavonoids in chronic venous insufficiency (CVI) – a study conducted from March 1997 to December 1998 in 23 countries with more than 10,000 patients suffering from CVI), 78% patients with symptoms of CVI did not receive treatment. Nowadays, surgical treatment methods for the VVD are very diverse. Currently, in developed countries, there is a trend towards an increase in minimally invasive interventions in the treatment of VVD performed on an outpatient basis. Among the proposed types of invasive methods of treatment, endovenous laser ablation, sclerotherapy, endovenous mechanochemical and radiofrequency obliteration are most widely used.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>варикозная болезнь нижних конечностей</kwd><kwd>склеротерапия</kwd><kwd>хроническая венозная недостаточность</kwd><kwd>эндовенозная лазерная коагуляция</kwd></kwd-group><kwd-group xml:lang="en"><kwd>varicose vein disease of the lower extremities</kwd><kwd>sclerotherapy</kwd><kwd>chronic venous insufficiency</kwd><kwd>endovenous laser ablation</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Chiesa R., Marone E.M., Limoni C., Volonte M., Schaefer E., Petrini O. Demographic factors and their relationship with the presence of CVI signs in Italy: the 24-cities cohort study. Eur J Vasc Endovasc Surg, 2005, vol. 30, no. 6, pp. 674-680. doi: 10.1016/j.ejvs.2005.06.016.</mixed-citation><mixed-citation xml:lang="en">Chiesa R., Marone E.M., Limoni C., Volonte M., Schaefer E., Petrini O. Demographic factors and their relationship with the presence of CVI signs in Italy: the 24-cities cohort study. Eur J Vasc Endovasc Surg, 2005, vol. 30, no. 6, pp. 674-680. doi: 10.1016/j.ejvs.2005.06.016.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Cornwall J.V., Dore C.J., Lewis J.D. Leg ulcers: epidemiology and aetiology. Br J Surg, 1986, vol. 3, no 9, pp. 693-696. doi: 10.1002/bjs.1800730905.</mixed-citation><mixed-citation xml:lang="en">Cornwall J.V., Dore C.J., Lewis J.D. Leg ulcers: epidemiology and aetiology. Br J Surg, 1986, vol. 3, no 9, pp. 693-696. doi: 10.1002/bjs.1800730905.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Cesarone M.R., Belcaro G., Nicolaides A.N., Geroulakos G., Griffin M., Incandela L. ‘Real’ epidemiology of varicose veins and chronic venous diseases: the San Valentino Vascular Screening Project. Angiology, 2002, vol. 53, no 2, pp. 119-130. doi: 10.1177/000331970205300201.</mixed-citation><mixed-citation xml:lang="en">Cesarone M.R., Belcaro G., Nicolaides A.N., Geroulakos G., Griffin M., Incandela L. ‘Real’ epidemiology of varicose veins and chronic venous diseases: the San Valentino Vascular Screening Project. Angiology, 2002, vol. 53, no 2, pp. 119-130. doi: 10.1177/000331970205300201.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Rabe E., Pannier F. Societal costs of chronic venous disease in CEAP C4, C5, C6 disease. Phlebology, 2010, vol. 25, suppl. 1, pp. 64-67. doi: 10.1258/phleb.2010.010s09.</mixed-citation><mixed-citation xml:lang="en">Rabe E., Pannier F. Societal costs of chronic venous disease in CEAP C4, C5, C6 disease. Phlebology, 2010, vol. 25, suppl. 1, pp. 64-67. doi: 10.1258/phleb.2010.010s09.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Lal B.K. Venous ulcers of the lower extremity: definition, epidemiology, and economic and social burdens. Semin Vasc Surg, 2015, vol. 28, no. 1, pp. 3-5. doi: 10.1053/j.semvascsurg.2015.05.002.</mixed-citation><mixed-citation xml:lang="en">Lal B.K. Venous ulcers of the lower extremity: definition, epidemiology, and economic and social burdens. Semin Vasc Surg, 2015, vol. 28, no. 1, pp. 3-5. doi: 10.1053/j.semvascsurg.2015.05.002.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Davies A.H. The seriousness of chronic venous disease: a review of real-world evidence. Adv Ther, 2019, vol. 36, suppl. 1, pp. 5-12. doi: 10.1007/s12325-019-0881-7.</mixed-citation><mixed-citation xml:lang="en">Davies A.H. The seriousness of chronic venous disease: a review of real-world evidence. Adv Ther, 2019, vol. 36, suppl. 1, pp. 5-12. doi: 10.1007/s12325-019-0881-7.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Nicolaides A., Kakkos S., Baekgaard N., Comerota A., de Maeseneer M., Eklof B. Management of chronic venous disorders of the lower limbs. Guidelines According to Scientific Evidence. Part I. Int Angiol, 2018, vol. 37, pp. 181-254. doi: 10.23736/S0392-9590.18.03999-8.</mixed-citation><mixed-citation xml:lang="en">Nicolaides A., Kakkos S., Baekgaard N., Comerota A., de Maeseneer M., Eklof B. Management of chronic venous disorders of the lower limbs. Guidelines According to Scientific Evidence. Part I. Int Angiol, 2018, vol. 37, pp. 181-254. doi: 10.23736/S0392-9590.18.03999-8.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Nicolaides A., Kakkos S., Eklof B., Perrin M., Nelzen O., Neglen P. Management of chronic venous disorders of the lower limbs – guidelines according to scientific evidence. Int Angiol, 2014, vol. 33, pp. 87-208.</mixed-citation><mixed-citation xml:lang="en">Nicolaides A., Kakkos S., Eklof B., Perrin M., Nelzen O., Neglen P. Management of chronic venous disorders of the lower limbs – guidelines according to scientific evidence. Int Angiol, 2014, vol. 33, pp. 87-208.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Wittens C., Davies A.H., Bækgaard N., Broholm R., Cavezzi A., Chastanet S. Management of Chronic Venous Disease: Clinical Practice Guidelines of the European Society for Vascular Surgery (ESVS). Eur J Vasc Endovasc Surg, 2015, vol. 49, pp. 678-737. doi: 10.1016/j.ejvs.2015.02.007.</mixed-citation><mixed-citation xml:lang="en">Wittens C., Davies A.H., Bækgaard N., Broholm R., Cavezzi A., Chastanet S. Management of Chronic Venous Disease: Clinical Practice Guidelines of the European Society for Vascular Surgery (ESVS). Eur J Vasc Endovasc Surg, 2015, vol. 49, pp. 678-737. doi: 10.1016/j.ejvs.2015.02.007.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Rossijskie klinicheskie rekomendacii po diagnostike i lecheniyu hronicheskih zabolevanij ven [Russian clinical guidelines for the diagnosis and treatment of chronic vein disease]. Flebologiya, 2018, vol. 12, no. 3, pp. 146-240. doi: 10.17116/flebo20187031146. (in Russian).</mixed-citation><mixed-citation xml:lang="en">Rossijskie klinicheskie rekomendacii po diagnostike i lecheniyu hronicheskih zabolevanij ven [Russian clinical guidelines for the diagnosis and treatment of chronic vein disease]. Flebologiya, 2018, vol. 12, no. 3, pp. 146-240. doi: 10.17116/flebo20187031146. (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Martinez M.J., Bonfill X., Moreno R.M., Vargas E., Capella D. Phlebotonics for venous insufficiency. Cochrane Database Syst Rev, 2005, vol. 20, no. 2, CD003229. doi: 10.1002/14651858.CD003229.pub2.</mixed-citation><mixed-citation xml:lang="en">Martinez M.J., Bonfill X., Moreno R.M., Vargas E., Capella D. Phlebotonics for venous insufficiency. Cochrane Database Syst Rev, 2005, vol. 20, no. 2, CD003229. doi: 10.1002/14651858.CD003229.pub2.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Todd M. Compression in older people. BJN, 2019, vol. 28, no. 9, pp. 566. doi: 10.12968/bjon.2019.28.9.566.</mixed-citation><mixed-citation xml:lang="en">Todd M. Compression in older people. BJN, 2019, vol. 28, no. 9, pp. 566. doi: 10.12968/bjon.2019.28.9.566.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Nicolaides A. The Benefits of Micronized Purified Flavonoid Fraction (MPFF) Throughout the Progression of Chronic Venous Disease. Adv Ther, 2020, vol. 37, suppl. 1, pp. 1-5. doi: 10.1007/s12325-019-01218-8.</mixed-citation><mixed-citation xml:lang="en">Nicolaides A. The Benefits of Micronized Purified Flavonoid Fraction (MPFF) Throughout the Progression of Chronic Venous Disease. Adv Ther, 2020, vol. 37, suppl. 1, pp. 1-5. doi: 10.1007/s12325-019-01218-8.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Bogachev V.Y., Boldin B.V., Lobanov V.N. Benefits of micronized purified flavonoid fraction as adjuvant therapy on inflammatory response after sclerotherapy. Int Angiol, 2018, vol. 37, pp. 71-78. doi: 10.23736/S0392-9590.17.03868-8.</mixed-citation><mixed-citation xml:lang="en">Bogachev V.Y., Boldin B.V., Lobanov V.N. Benefits of micronized purified flavonoid fraction as adjuvant therapy on inflammatory response after sclerotherapy. Int Angiol, 2018, vol. 37, pp. 71-78. doi: 10.23736/S0392-9590.17.03868-8.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Mansilha A., Sousa J. Benefits of venoactive drug therapy in surgical or endovenous treatment for varicose veins: a systematic review. Int Angiol, 2019, vol. 38, no. 4, pp. 291-298. doi: 10.23736/S0392-9590.19.04216-0.</mixed-citation><mixed-citation xml:lang="en">Mansilha A., Sousa J. Benefits of venoactive drug therapy in surgical or endovenous treatment for varicose veins: a systematic review. Int Angiol, 2019, vol. 38, no. 4, pp. 291-298. doi: 10.23736/S0392-9590.19.04216-0.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Jawien A., Bouskela E., Allaert F.A., Nicolaides A.N. The place of Ruscus extract, hesperidin methyl chalcone, and vitamin C in the management of chronic venous disease. Int Angiol, 2017, vol. 36, no. 1, pp. 31-41. doi: 10.23736/S0392-9590.16.03788-3.</mixed-citation><mixed-citation xml:lang="en">Jawien A., Bouskela E., Allaert F.A., Nicolaides A.N. The place of Ruscus extract, hesperidin methyl chalcone, and vitamin C in the management of chronic venous disease. Int Angiol, 2017, vol. 36, no. 1, pp. 31-41. doi: 10.23736/S0392-9590.16.03788-3.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Kakkos S.K., Bouskela E., Jawien A., Nicolaides A.N. New data on chronic venous disease: a new place for Cyclo 3® Fort. Int Angiol, 2018, vol. 37, no. 1, pp. 85-92. doi: 10.23736/S0392-9590.17.03935-9.</mixed-citation><mixed-citation xml:lang="en">Kakkos S.K., Bouskela E., Jawien A., Nicolaides A.N. New data on chronic venous disease: a new place for Cyclo 3® Fort. Int Angiol, 2018, vol. 37, no. 1, pp. 85-92. doi: 10.23736/S0392-9590.17.03935-9.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Kakkos S.K., Guex J.J., Lugli M., Nicolaides A.N. CEAP clinical classes C0S-C4: differences, similarities and role of Ruscus + HMC + vitamin C in patients with chronic venous disease. Int Angiol, 2020, vol. 39, no. 2, pp. 118-124. doi: 10.23736/S0392-9590.20.04341-2.</mixed-citation><mixed-citation xml:lang="en">Kakkos S.K., Guex J.J., Lugli M., Nicolaides A.N. CEAP clinical classes C0S-C4: differences, similarities and role of Ruscus + HMC + vitamin C in patients with chronic venous disease. Int Angiol, 2020, vol. 39, no. 2, pp. 118-124. doi: 10.23736/S0392-9590.20.04341-2.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">De Almeida Cyrino F.Z.G., Balthazar D.S., Sicuro F.L., Bouskela E. Effects of venotonic drugs on the microcirculation: Comparison between Ruscus extract and micronized diosmine. Clin Hemorheol Microcirc, 2018, vol. 68, no. 4, pp. 371-382. doi: 10.3233/CH-170281.</mixed-citation><mixed-citation xml:lang="en">De Almeida Cyrino F.Z.G., Balthazar D.S., Sicuro F.L., Bouskela E. Effects of venotonic drugs on the microcirculation: Comparison between Ruscus extract and micronized diosmine. Clin Hemorheol Microcirc, 2018, vol. 68, no. 4, pp. 371-382. doi: 10.3233/CH-170281.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Nicolaides A., Kakkos S., Baekgaard N., Comerota A., de Maeseneer M., Eklof B. Management of chronic venous disorders of the lower limbs: guidelines according to scientific evidence. Part II. Int Angiol, 2020, vol. 39, no. 3, pp. 175-240. doi: 10.23736/S0392-9590.20.04388-6.</mixed-citation><mixed-citation xml:lang="en">Nicolaides A., Kakkos S., Baekgaard N., Comerota A., de Maeseneer M., Eklof B. Management of chronic venous disorders of the lower limbs: guidelines according to scientific evidence. Part II. Int Angiol, 2020, vol. 39, no. 3, pp. 175-240. doi: 10.23736/S0392-9590.20.04388-6.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Marsden G., Perry M., Kelley K., Davies A.H. Guideline Development Group. Diagnosis and management of varicose veins in the legs: summary of NICE guidance. BMJ, 2013, vol. 347, pp. 4279. doi: 10.1136/bmj. f4279.</mixed-citation><mixed-citation xml:lang="en">Marsden G., Perry M., Kelley K., Davies A.H. Guideline Development Group. Diagnosis and management of varicose veins in the legs: summary of NICE guidance. BMJ, 2013, vol. 347, pp. 4279. doi: 10.1136/bmj. f4279.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Gloviczki P., Comerota A.J., Dalsing M.C. The care of patients with varicose veins and associated chronic venous diseases: clinical practice guidelines of the Society for Vascular Surgery and the American Venous Forum. J Vasc Surg, 2011, vol. 53, suppl. 5, pp. 2-48. doi: 10.1016/j.jvs.2011.01.079.</mixed-citation><mixed-citation xml:lang="en">Gloviczki P., Comerota A.J., Dalsing M.C. The care of patients with varicose veins and associated chronic venous diseases: clinical practice guidelines of the Society for Vascular Surgery and the American Venous Forum. J Vasc Surg, 2011, vol. 53, suppl. 5, pp. 2-48. doi: 10.1016/j.jvs.2011.01.079.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Davies A.H. The seriousness of chronic venous disease: a review of real-world evidence. Adv Ther, 2019, vol. 36, suppl. 1, pp. 5-12. doi: 10.1007/s12325-019-0881-7.</mixed-citation><mixed-citation xml:lang="en">Davies A.H. The seriousness of chronic venous disease: a review of real-world evidence. Adv Ther, 2019, vol. 36, suppl. 1, pp. 5-12. doi: 10.1007/s12325-019-0881-7.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Smith P. The causes of skin damage and leg ulceration in chronic venous disease. Int J Low Extrem Wounds, 2006, vol. 5, no. 3, pp. 160-168. doi: 10.1177/1534734606292429.</mixed-citation><mixed-citation xml:lang="en">Smith P. The causes of skin damage and leg ulceration in chronic venous disease. Int J Low Extrem Wounds, 2006, vol. 5, no. 3, pp. 160-168. doi: 10.1177/1534734606292429.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Cavezzi A., Tessari L. Foam sclerotherapy techniques: different gases and methods of preparation, catheter versus direct injection. Phlebology, 2009, vol. 24, no. 6, pp. 247-251. doi: 10.1258/phleb.2009.009061.</mixed-citation><mixed-citation xml:lang="en">Cavezzi A., Tessari L. Foam sclerotherapy techniques: different gases and methods of preparation, catheter versus direct injection. Phlebology, 2009, vol. 24, no. 6, pp. 247-251. doi: 10.1258/phleb.2009.009061.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Breu F.X., Guggenbichler S. European Consensus Meeting on Foam Sclerotherapy, April, 4-6, 2003, Tegernsee, Germany. Dermatol Surg, 2004, vol. 30, pp. 709-717. doi: 10.1111/j.1524-4725.2004.30209.x.</mixed-citation><mixed-citation xml:lang="en">Breu F.X., Guggenbichler S. European Consensus Meeting on Foam Sclerotherapy, April, 4-6, 2003, Tegernsee, Germany. Dermatol Surg, 2004, vol. 30, pp. 709-717. doi: 10.1111/j.1524-4725.2004.30209.x.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Baeshko A.A. Pennaya skleroterapiya: istoriya razvitiya i sovremennye dannye [Foam sclerotherapy: history of development and current evidence.]. Novosti hirurgii, 2012, vol. 20, no 4, pp. 101-110. (in Russian).</mixed-citation><mixed-citation xml:lang="en">Baeshko A.A. Pennaya skleroterapiya: istoriya razvitiya i sovremennye dannye [Foam sclerotherapy: history of development and current evidence.]. Novosti hirurgii, 2012, vol. 20, no 4, pp. 101-110. (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Coleridge Smith P. Saphenous ablation: sclerosant or sclerofoam? Semin Vasc Surg, 2005, vol.18, no. 1, pp. 19-24. doi: 10.1053/j.semvascsurg.2004.12.007.</mixed-citation><mixed-citation xml:lang="en">Coleridge Smith P. Saphenous ablation: sclerosant or sclerofoam? Semin Vasc Surg, 2005, vol.18, no. 1, pp. 19-24. doi: 10.1053/j.semvascsurg.2004.12.007.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Cavezzi A., Frullini A. The role of sclerosing foam in ultrasound guided sclerotherapy of the saphenous veins of recurrent varicose veins: our personal experience. Aust N Z J Phlebol, 1999, vol. 3, pp. 49-50.</mixed-citation><mixed-citation xml:lang="en">Cavezzi A., Frullini A. The role of sclerosing foam in ultrasound guided sclerotherapy of the saphenous veins of recurrent varicose veins: our personal experience. Aust N Z J Phlebol, 1999, vol. 3, pp. 49-50.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Tessari L., Cavezzi A., Frullini A. Preliminary experience with a new sclerosing foam in the treatment of varicose veins. Dermatol Surg, 2001, vol. 27, no. 1, pp. 58-60.</mixed-citation><mixed-citation xml:lang="en">Tessari L., Cavezzi A., Frullini A. Preliminary experience with a new sclerosing foam in the treatment of varicose veins. Dermatol Surg, 2001, vol. 27, no. 1, pp. 58-60.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Jia X., Mowatt G., Burr J.M., Cassar K., Cooke J., Fraser C. Systematic review of foam sclerotherapy for varicose veins. Br J Surg, 2007, vol. 94, pp. 925-936. doi: 10.1002/bjs.5891.</mixed-citation><mixed-citation xml:lang="en">Jia X., Mowatt G., Burr J.M., Cassar K., Cooke J., Fraser C. Systematic review of foam sclerotherapy for varicose veins. Br J Surg, 2007, vol. 94, pp. 925-936. doi: 10.1002/bjs.5891.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Hamann S.A.S., Giang J., De Maeseneer M.G.R., Nijsten T.E.C., van den Bos R.R. Five year results of great saphenous vein treatment: a meta-analysis. Eur J Vasc Endovasc Surg, 2017, vol. 54, pp. 760-770. doi: 10.1016/j.ejvs.2017.08.034.</mixed-citation><mixed-citation xml:lang="en">Hamann S.A.S., Giang J., De Maeseneer M.G.R., Nijsten T.E.C., van den Bos R.R. Five year results of great saphenous vein treatment: a meta-analysis. Eur J Vasc Endovasc Surg, 2017, vol. 54, pp. 760-770. doi: 10.1016/j.ejvs.2017.08.034.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Rasmussen L.H., Lawaetz M., Bjoern L., Vennits B., Blemings A., Eklof B. Randomized clinical trial comparing endovenous laser ablation, radiofrequency ablation, foam sclerotherapy and surgical stripping for great saphenous varicose veins. Br J Surg, 2011, vol. 98, no 8, pp. 1079-1087. doi: 10.1002/bjs.7555.</mixed-citation><mixed-citation xml:lang="en">Rasmussen L.H., Lawaetz M., Bjoern L., Vennits B., Blemings A., Eklof B. Randomized clinical trial comparing endovenous laser ablation, radiofrequency ablation, foam sclerotherapy and surgical stripping for great saphenous varicose veins. Br J Surg, 2011, vol. 98, no 8, pp. 1079-1087. doi: 10.1002/bjs.7555.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Wallace T., El-Sheikha J., Nandhra S., Leung C., Mohamed A., Harwood A., Smith G., Carradice D., Chetter I. Long-term outcomes of endovenous laser ablation and conventional surgery for great saphenous varicose veins. Br J Surg, 2018, vol. 105, no. 13, pp. 1759-1767. doi: 10.1002/bjs.10961.</mixed-citation><mixed-citation xml:lang="en">Wallace T., El-Sheikha J., Nandhra S., Leung C., Mohamed A., Harwood A., Smith G., Carradice D., Chetter I. Long-term outcomes of endovenous laser ablation and conventional surgery for great saphenous varicose veins. Br J Surg, 2018, vol. 105, no. 13, pp. 1759-1767. doi: 10.1002/bjs.10961.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Van den Bos R.R., Neumann M., De Roos K.P. Endovenous laser ablation-induced complications: review of literature and new cases. Dermatol Surg, 2009, vol. 35, pp. 1206-1214. doi: 10.1111/j.1524-4725.2009.01215. x.</mixed-citation><mixed-citation xml:lang="en">Van den Bos R.R., Neumann M., De Roos K.P. Endovenous laser ablation-induced complications: review of literature and new cases. Dermatol Surg, 2009, vol. 35, pp. 1206-1214. doi: 10.1111/j.1524-4725.2009.01215. x.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Sichlau M.J., Ryu R.K. Cutaneous thermal injury after endovenous laser ablation of the great saphenous vein. J Vasc Interv Radiol, 2004, vol. 15, pp. 865-867. doi: 10.1097/01.RVI.0000136968.64870.07.</mixed-citation><mixed-citation xml:lang="en">Sichlau M.J., Ryu R.K. Cutaneous thermal injury after endovenous laser ablation of the great saphenous vein. J Vasc Interv Radiol, 2004, vol. 15, pp. 865-867. doi: 10.1097/01.RVI.0000136968.64870.07.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Sun J.J., Chowdhury M.M., Sadat U., Hayes P.D., Tang T.Y. Mechanochemical ablation for treatment of truncal venous insufficiency: a review of the current literature. J Vasc Interv Radiol, 2017, vol. 28, no. 10, pp. 1422-1431. doi: 10.1016/j.jvir.2017.07.002.</mixed-citation><mixed-citation xml:lang="en">Sun J.J., Chowdhury M.M., Sadat U., Hayes P.D., Tang T.Y. Mechanochemical ablation for treatment of truncal venous insufficiency: a review of the current literature. J Vasc Interv Radiol, 2017, vol. 28, no. 10, pp. 1422-1431. doi: 10.1016/j.jvir.2017.07.002.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Ciostek P., Kowalski M., Woźniak W., Miłek T., Myrcha P., Migda B. Phlebogriffe – a new device for mechanochemical ablation of incompetent saphenous veins: a pilot study. Phlebological Review, 2015, vol. 23, no. 3, pp. 72-77. doi: 10.5114/pr.2015.57466.</mixed-citation><mixed-citation xml:lang="en">Ciostek P., Kowalski M., Woźniak W., Miłek T., Myrcha P., Migda B. Phlebogriffe – a new device for mechanochemical ablation of incompetent saphenous veins: a pilot study. Phlebological Review, 2015, vol. 23, no. 3, pp. 72-77. doi: 10.5114/pr.2015.57466.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Khryshchanovich V.Y., Nebylitsin Y.S., Kosinets V.A. Efficacy of micronized purified flavonoid fraction-based venoactive therapy after endovenous mechanochemical obliteration: prospective comparative study. Drugs Real World Outcomes, 2021, vol. 8, no. 3, pp. 349-358. doi: 10.1007/s40801-021-00249-4.</mixed-citation><mixed-citation xml:lang="en">Khryshchanovich V.Y., Nebylitsin Y.S., Kosinets V.A. Efficacy of micronized purified flavonoid fraction-based venoactive therapy after endovenous mechanochemical obliteration: prospective comparative study. Drugs Real World Outcomes, 2021, vol. 8, no. 3, pp. 349-358. doi: 10.1007/s40801-021-00249-4.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Zubilewicz T., Terlecki P., Terlecki K., Przywara S., Rybak J., Ilzecki M. Application of endovenous mechanochemical ablation (MOCA) with Flebogrif™ to treat varicose veins of the lower extremities: a single center experience over 3 months of observation. Acta Angiologica, 2016, vol. 22, no. 4, pp. 137-142. doi: 10.5603/AA.2016.0012.</mixed-citation><mixed-citation xml:lang="en">Zubilewicz T., Terlecki P., Terlecki K., Przywara S., Rybak J., Ilzecki M. Application of endovenous mechanochemical ablation (MOCA) with Flebogrif™ to treat varicose veins of the lower extremities: a single center experience over 3 months of observation. Acta Angiologica, 2016, vol. 22, no. 4, pp. 137-142. doi: 10.5603/AA.2016.0012.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Johanes N., Wardhana A., Ghea C. Mechanical Occlusion Chemically Assisted Ablation (MOCA) for Saphenous Vein Insufficiency: A Meta-Analysis of a Randomized Trial. Int J Vasc Med, 2020, vol. 29. doi: 10.1155/2020/8758905.</mixed-citation><mixed-citation xml:lang="en">Johanes N., Wardhana A., Ghea C. Mechanical Occlusion Chemically Assisted Ablation (MOCA) for Saphenous Vein Insufficiency: A Meta-Analysis of a Randomized Trial. Int J Vasc Med, 2020, vol. 29. doi: 10.1155/2020/8758905.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Tawfik A.M., Sorour W.A., El-Laboudy M.E. Laser ablation versus mechanochemical ablation in the treatment of primary varicose veins: A randomized clinical trial. J Vasc Surg Venous and Lym Dis, 2020, vol. 8, no 2, pp. 211-215. doi: 10.1016/j.jvsv.2019.10.025.</mixed-citation><mixed-citation xml:lang="en">Tawfik A.M., Sorour W.A., El-Laboudy M.E. Laser ablation versus mechanochemical ablation in the treatment of primary varicose veins: A randomized clinical trial. J Vasc Surg Venous and Lym Dis, 2020, vol. 8, no 2, pp. 211-215. doi: 10.1016/j.jvsv.2019.10.025.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Vähäaho S., Halmesmäki K., Mahmoud O., Albäck A., Noronen K., Venermo M. Three-year results of a randomized controlled trial comparing mechanochemical and thermal ablation in the treatment of insufficient great saphenous veins. J Vasc Surg Venous and Lym Dis, 2021, vol. 9, no 3, pp. 652-659. doi: 10.1016/j.jvsv.2020.08.007.</mixed-citation><mixed-citation xml:lang="en">Vähäaho S., Halmesmäki K., Mahmoud O., Albäck A., Noronen K., Venermo M. Three-year results of a randomized controlled trial comparing mechanochemical and thermal ablation in the treatment of insufficient great saphenous veins. J Vasc Surg Venous and Lym Dis, 2021, vol. 9, no 3, pp. 652-659. doi: 10.1016/j.jvsv.2020.08.007.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Mohamed A.H., Leung C., Wallace T., Smith G., Carradice D., Chetter I. A randomized controlled trial of endovenous laser ablation versus mechanochemical ablation with ClariVein in the management of superficial venous incompetence (LAMA trial). Ann Surg, 2021, vol. 273, no 6, pp. e188-e195. doi: 10.1097/SLA.0000000000003749.</mixed-citation><mixed-citation xml:lang="en">Mohamed A.H., Leung C., Wallace T., Smith G., Carradice D., Chetter I. A randomized controlled trial of endovenous laser ablation versus mechanochemical ablation with ClariVein in the management of superficial venous incompetence (LAMA trial). Ann Surg, 2021, vol. 273, no 6, pp. e188-e195. doi: 10.1097/SLA.0000000000003749.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Smith S.R., Goldman M.P. Tumescent anesthesia in ambulatory phlebectomy. Dermatol Surg, 1998, vol. 24, pp. 453. doi: 10.1111/j.1524-4725.1998.tb04187.x.</mixed-citation><mixed-citation xml:lang="en">Smith S.R., Goldman M.P. Tumescent anesthesia in ambulatory phlebectomy. Dermatol Surg, 1998, vol. 24, pp. 453. doi: 10.1111/j.1524-4725.1998.tb04187.x.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Mansilha A., Sousa J. Benefits of venoactive drug therapy in surgical or endovenous treatment for varicose veins: a systematic review. Int Angiol, 2019, vol. 38, no. 4, pp. 291-298. doi: 10.23736/S0392-9590.19.04216-0.</mixed-citation><mixed-citation xml:lang="en">Mansilha A., Sousa J. Benefits of venoactive drug therapy in surgical or endovenous treatment for varicose veins: a systematic review. Int Angiol, 2019, vol. 38, no. 4, pp. 291-298. doi: 10.23736/S0392-9590.19.04216-0.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Hartmann K., Stenger D., Hartmann M., Rafi-Stenger L. Endochirurgie versus offene Chirugie der Varikose. Versuch einer Wertung. Hautarzt, 2017, vol. 68, no. 8, pp. 603-613. doi: 10.1007/s00105-017-3996-2.</mixed-citation><mixed-citation xml:lang="en">Hartmann K., Stenger D., Hartmann M., Rafi-Stenger L. Endochirurgie versus offene Chirugie der Varikose. Versuch einer Wertung. Hautarzt, 2017, vol. 68, no. 8, pp. 603-613. doi: 10.1007/s00105-017-3996-2.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">O’Donnell T.F., Passman M.A., Marston W.A., Ennis W.J., Dalsing M., Kistner R.L. Management of venous leg ulcers: Clinical practice guidelines of the Society for Vascular Surgery® and the American Venous Forum. J Vasc Surg, 2014, vol. 60, pp. 3S-59S. doi: 10.1016/j.jvs.2014.04.049.</mixed-citation><mixed-citation xml:lang="en">O’Donnell T.F., Passman M.A., Marston W.A., Ennis W.J., Dalsing M., Kistner R.L. Management of venous leg ulcers: Clinical practice guidelines of the Society for Vascular Surgery® and the American Venous Forum. J Vasc Surg, 2014, vol. 60, pp. 3S-59S. doi: 10.1016/j.jvs.2014.04.049.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Mahenthiran A.K., Natarajan J.P., Bertges D.J., Huffman K.M., Eldrup-Jorgensen J., Lemmon G.W. Impact of COVID-19 on the Society for Vascular Surgery Vascular Quality Initiative Venous Procedure Registries (varicose vein and inferior vena cava filter). J Vasc Surg Venous Lymphat Disord, 2021, vol. 9, no. 5, pp. 1093-1098. doi: 10.1016/j.jvsv.2021.01.002.</mixed-citation><mixed-citation xml:lang="en">Mahenthiran A.K., Natarajan J.P., Bertges D.J., Huffman K.M., Eldrup-Jorgensen J., Lemmon G.W. Impact of COVID-19 on the Society for Vascular Surgery Vascular Quality Initiative Venous Procedure Registries (varicose vein and inferior vena cava filter). J Vasc Surg Venous Lymphat Disord, 2021, vol. 9, no. 5, pp. 1093-1098. doi: 10.1016/j.jvsv.2021.01.002.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
