emcardioНеотложная кардиология и кардиоваскулярные рискиEmergency Cardiology and Cardiovascular Risks journal2616-633XБелорусский государственный медицинский университет10.51922/2616-633X.2023.7.1.1800emcardio-66Research ArticleОригинальные научные публикацииOriginal Scientific ResearchДинамика показателей свертывающей системы крови в зависимости от выраженности хронической дыхательной недостаточности и дисфункции эндотелия у пациентов с хронической обструктивной болезнью легкихDynamics of blood coagulation system indicators depending on the severity of chronic respiratory failure and endothelial dysfunction in patients with chronic obstructive pulmonary diseaseЛапицкийД. В.LapitskiD. V.

г. Минск

Minsk

lapitskiy1973@mail.ruПупкевичВ. А.PupkevichV. A.

г. Минск

Minsk

ЧириковаТ. В.ChirikovaT. V.

г. Минск

Minsk

ДвораковскийИ. С.DvorakovskiI. S.

г. Минск

Minsk

ГончарикА. В.GoncharikA. V.

г. Минск

Minsk

КартунЛ. В.KartunL. V.

г. Минск

Minsk

ХодосовскаяЕ. В.HodosovskayaE. V.

г. Минск

Minsk

ИбрагимоваЖ. А.IbrahimovaZh. A.

г. Минск

Minsk

МитьковскаяН. П.MitkovskayaN. P.

г. Минск

Minsk

Государственное учреждение «432 Главный военный клинический медицинский центр МО ВС Республики Беларусь»; Учреждение образования «Белорусский государственный медицинский университет», кафедра кардиологии и внутренних болезней432 Order of the Red Star Chief Military Clinical Medical Center of the Armed Forces of the Republic of Belarus; Belarusian State Medical University, Department of Cardiology and Internal MedicineГосударственное учреждение «432 Главный военный клинический медицинский центр МО ВС Республики Беларусь»432 Order of the Red Star Chief Military Clinical Medical Center of the Armed Forces of the Republic of BelarusУчреждение образования «Белорусский государственный медицинский университет», лаборатория биохимических методов исследованияBelarusian State Medical University, Biochemical LaboratoryУчреждение образования «Белорусский государственный медицинский университет», кафедра кардиологии и внутренних болезнейBelarusian State Medical University, Department of Cardiology and Internal Medicine2023200620257118001815Copyright © Лапицкий Д.В., Пупкевич В.А., Чирикова Т.В., Двораковский И.С., Гончарик А.В., Картун Л.В., Ходосовская Е.В., Ибрагимова Ж.А., Митьковская Н.П., 20252025Лапицкий Д.В., Пупкевич В.А., Чирикова Т.В., Двораковский И.С., Гончарик А.В., Картун Л.В., Ходосовская Е.В., Ибрагимова Ж.А., Митьковская Н.П.Lapitski D.V., Pupkevich V.A., Chirikova T.V., Dvorakovski I.S., Goncharik A.V., Kartun L.V., Hodosovskaya E.V., Ibrahimova Z.A., Mitkovskaya N.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://emcardio.bsmu.by/jour/article/view/66

Публикация посвящена изучению показателей системы гемостаза, маркеров функции эндотелия, про- и противовоспалительных цитокинов у пациентов с хронической обструктивной болезнью легких в зависимости от выраженности хронической дыхательной недостаточности и нарушений насыщения гемоглобина артериальной крови кислородом. Авторами выделена группа пациентов с признаками коагулопатии потребления как проявление иммунотромбоза, установлена связь нарушений в системе гемостаза с гипоксемией и выраженной дыхательной недостаточностью. Также авторами выделена группа пациентов с признаками тромбовоспаления, показана его роль в сосудистом повреждении. Разработан алгоритм клинической оценки пациентов с коагулопатией потребления, тромбовоспалением и высказано предложение об их дальнейшем ведении.

The publication is devoted to the study of hemostasis system parameters, markers of endothelial function, pro- and anti-inflammatory cytokines in patients with chronic obstructive pulmonary disease depending on the severity of chronic respiratory failure and disorders of arterial blood hemoglobin oxygen saturation. The authors have singled out a group of patients with signs of disseminated intravascular coagulation as a manifestation of immune thrombosis; the relationship of hemostasis disorders with hypoxemia and severe respiratory failure has been established. The authors also singled out a group of patients with the signs of thromboinflammation and demonstrated its role in vascular damage. The algorithm of clinical evaluation of patients with disseminated intravascular coagulation, and thromboinflammation is developed and their further management strategy has been suggested.

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The authors declare that there are no conflicts of interest present.