<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">emcardio</journal-id><journal-title-group><journal-title xml:lang="ru">Неотложная кардиология и кардиоваскулярные риски</journal-title><trans-title-group xml:lang="en"><trans-title>Emergency Cardiology and Cardiovascular Risks journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2616-633X</issn><publisher><publisher-name>Белорусский государственный медицинский университет</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.51922/2616-633X.2023.7.1.1828</article-id><article-id custom-type="elpub" pub-id-type="custom">emcardio-63</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Оригинальные научные публикации</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Original Scientific Research</subject></subj-group></article-categories><title-group><article-title>Доклиническая кардиотоксичность при системном лечении резектабельного рака молочной железы</article-title><trans-title-group xml:lang="en"><trans-title>Preclinical cardiotoxicity in systemic treatment of resectable breast cancer</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Черняк</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Chernyak</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Минск</p></bio><bio xml:lang="en"><p>Minsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ковш</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kovsh</surname><given-names>Ye. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Минск</p></bio><bio xml:lang="en"><p>Minsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Черневская</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Chernevskaya</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Минск</p></bio><bio xml:lang="en"><p>Minsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Севрук</surname><given-names>Т. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Sevruk</surname><given-names>T. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Минск</p></bio><bio xml:lang="en"><p>Minsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Горбат</surname><given-names>Т. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Gorbat</surname><given-names>T. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Минск</p></bio><bio xml:lang="en"><p>Minsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рачок</surname><given-names>Л. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Rachok</surname><given-names>L. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Минск</p></bio><bio xml:lang="en"><p>Minsk</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ахмед</surname><given-names>Н. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Akhmed</surname><given-names>N. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Минск</p></bio><bio xml:lang="en"><p>Minsk</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Павлова</surname><given-names>О. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Pavlova</surname><given-names>O. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Минск</p></bio><bio xml:lang="en"><p>Minsk</p></bio><email xlink:type="simple">olga.s_pavlova@yahoo.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГУ «Республиканский научно-практический центр «Кардиология»</institution></aff><aff xml:lang="en"><institution>Republican Scientific and Practical Center of Cardiology</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>УО «Белорусский государственный медицинский университет»</institution></aff><aff xml:lang="en"><institution>Belarusian State Medical University</institution></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ГУ «Республиканский научно-практический центр онкологии и медицинской радиологии им. Н.Н. Александрова»</institution></aff><aff xml:lang="en"><institution>Republican Scientific and Practical Center of Oncology and Medical Radiology named after N.N. Alexandrov</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>20</day><month>06</month><year>2025</year></pub-date><volume>7</volume><issue>1</issue><fpage>1828</fpage><lpage>1834</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Черняк С.В., Ковш Е.В., Черневская М.В., Севрук Т.В., Горбат Т.В., Рачок Л.В., Ахмед Н.Н., Павлова О.С., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Черняк С.В., Ковш Е.В., Черневская М.В., Севрук Т.В., Горбат Т.В., Рачок Л.В., Ахмед Н.Н., Павлова О.С.</copyright-holder><copyright-holder xml:lang="en">Chernyak S.V., Kovsh Y.V., Chernevskaya M.V., Sevruk T.V., Gorbat T.V., Rachok L.V., Akhmed N.N., Pavlova O.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://emcardio.bsmu.by/jour/article/view/63">https://emcardio.bsmu.by/jour/article/view/63</self-uri><abstract><p>Исследование онкологических пациентов с оценкой риска кардиотоксичности химиопрепаратов осуществлялось с использованием диагностических методов: эхокардиографии с оценкой глобальной деформации миокарда, магнитно-резонансной томографии сердца, анализа сердечных биомаркеров и жесткости артерий. Применение указанных методов позволило выявить субклиническое поражение сердца и сосудов у пациентов при системном лечении пациентов с резектабельным раком молочной железы.</p></abstract><trans-abstract xml:lang="en"><p>Study of cancer patients and assessment of the cardiotoxicity risk of chemotoxic drugs has been performed using the following diagnostic methods: echocardiography with assessment of global myocardial deformation, cardiac magnetic resonance imaging, analysis of cardiac biomarkers and arterial stiffness. Application of the mentioned methods allowed to detect subclinical heart and vascular lesions before the appearance of clinical symptoms in patients resectable breast cancer and systemic treatment.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>сердечно-сосудистые заболевания</kwd><kwd>кардиотоксичность</kwd><kwd>рак молочной железы</kwd><kwd>глобальная продольная деформация</kwd><kwd>жесткость артерий</kwd><kwd>сердечно-лодыжечный сосудистый индекс</kwd><kwd>скорость распространения пульсовой волны</kwd><kwd>экстрацеллюлярный объем левого желудочка</kwd></kwd-group><kwd-group xml:lang="en"><kwd>myocardial infarction</kwd><kwd>heart failure</kwd><kwd>radiation diagnostic methods</kwd><kwd>index of microcirculatory resistance</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Chazova I.E., Ageev F.T., Aksenova A.V., Vitsenja M.V., Giljarov M.Ju., Martynjuk T.V., Panchenko E.P., Poltavskaja M.G., Potievskaja V.I., Trofimova O.P., Fedotkina Ju.A. Evrazijskie klinicheskie rekomendatsii po diagnostike, profilaktike i lecheniju serdechno-sosudistyh oslozhnenij pri protivoopuholevoj terapii [Eurasian clinical guidelines for cardiovascular complications of cancer treatments: diagnosis, prevention and treatment]. Eurasian heart journal, 2022, vol. 37, no. 1. doi: 10.38109/2225-1685-2022-1-6-79 (in Russion).</mixed-citation><mixed-citation xml:lang="en">Chazova I.E., Ageev F.T., Aksenova A.V., Vitsenja M.V., Giljarov M.Ju., Martynjuk T.V., Panchenko E.P., Poltavskaja M.G., Potievskaja V.I., Trofimova O.P., Fedotkina Ju.A. Evrazijskie klinicheskie rekomendatsii po diagnostike, profilaktike i lecheniju serdechno-sosudistyh oslozhnenij pri protivoopuholevoj terapii [Eurasian clinical guidelines for cardiovascular complications of cancer treatments: diagnosis, prevention and treatment]. Eurasian heart journal, 2022, vol. 37, no. 1. doi: 10.38109/2225-1685-2022-1-6-79 (in Russion).</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Lyon A.R., López-Fernández T., Couch L.S., Asteggiano R., Aznar M.C., Bergler-Klein J., Boriani G., Cardinale D., Cordoba R., Cosyns B., Cutter D.J., de Azambuja E., de Boer R.A., Dent S.F., Farmakis D., Gevaert S.A., Gorog D.A., Herrmann J., Lenihan D., Moslehi J., Moura B., Salinger S.S., Stephens R., Suter T.M., Szmit S., Tamargo J., Thavendiranathan P., Tocchetti C.G., van der Meer P., van der Pal H.J.H.; ESC Scientific Document Group. 2022 ESC Guidelines on cardio-oncology developed in collaboration with the European Hematology Association (EHA), the European Society for Therapeutic Radiology and Oncology (ESTRO) and the International Cardio-Oncology Society (IC-OS). Eur Heart J, 2022, vol. 43(41), pp. 4229-4361. doi: 10.1093/eurheartj/ehac244.</mixed-citation><mixed-citation xml:lang="en">Lyon A.R., López-Fernández T., Couch L.S., Asteggiano R., Aznar M.C., Bergler-Klein J., Boriani G., Cardinale D., Cordoba R., Cosyns B., Cutter D.J., de Azambuja E., de Boer R.A., Dent S.F., Farmakis D., Gevaert S.A., Gorog D.A., Herrmann J., Lenihan D., Moslehi J., Moura B., Salinger S.S., Stephens R., Suter T.M., Szmit S., Tamargo J., Thavendiranathan P., Tocchetti C.G., van der Meer P., van der Pal H.J.H.; ESC Scientific Document Group. 2022 ESC Guidelines on cardio-oncology developed in collaboration with the European Hematology Association (EHA), the European Society for Therapeutic Radiology and Oncology (ESTRO) and the International Cardio-Oncology Society (IC-OS). Eur Heart J, 2022, vol. 43(41), pp. 4229-4361. doi: 10.1093/eurheartj/ehac244.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Curigliano G., Lenihan D., Fradley M., et al. Management of cardiac disease in cancer patients throughout oncological treatment: ESMO consensus recommendations. Ann Oncol, 2020, vol. 31, no. 2, pp. 171-190. doi: 10.1016/j.annonc.2019.10.023.</mixed-citation><mixed-citation xml:lang="en">Curigliano G., Lenihan D., Fradley M., et al. Management of cardiac disease in cancer patients throughout oncological treatment: ESMO consensus recommendations. Ann Oncol, 2020, vol. 31, no. 2, pp. 171-190. doi: 10.1016/j.annonc.2019.10.023.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Papageorgiou C., Andrikopoulou A., Dimopoulos M.A., Zagouri F. Cardiovascular toxicity of breast cancer treatment: an update. Cancer Chemother Pharmacol, 2021, vol. 88(1), pp. 15-24. doi: 10.1007/s00280-021-04254-w.</mixed-citation><mixed-citation xml:lang="en">Papageorgiou C., Andrikopoulou A., Dimopoulos M.A., Zagouri F. Cardiovascular toxicity of breast cancer treatment: an update. Cancer Chemother Pharmacol, 2021, vol. 88(1), pp. 15-24. doi: 10.1007/s00280-021-04254-w.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Ram P., Tiu A., Lo K. B., Parikh K., Shah M. Trends in the prevalence of malignancy among patients admitted with acute heart failure and associated outcomes: a nationwide population-based study. Heart Failure Reviews, 2019, vol. 24, no. 6, pp. 989-995. doi: 10.1007/s10741-019-09808-y.</mixed-citation><mixed-citation xml:lang="en">Ram P., Tiu A., Lo K. B., Parikh K., Shah M. Trends in the prevalence of malignancy among patients admitted with acute heart failure and associated outcomes: a nationwide population-based study. Heart Failure Reviews, 2019, vol. 24, no. 6, pp. 989-995. doi: 10.1007/s10741-019-09808-y.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Larsen C.M., Mulvagh S.L. Cardio-oncology: what you need to know now for clinical practice and echocardiography. Echo Res Prat, 2017. vol. 4, no. 1, pp. 33-41. doi:10.1530/ERP-17-0013.</mixed-citation><mixed-citation xml:lang="en">Larsen C.M., Mulvagh S.L. Cardio-oncology: what you need to know now for clinical practice and echocardiography. Echo Res Prat, 2017. vol. 4, no. 1, pp. 33-41. doi:10.1530/ERP-17-0013.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Fei H.W., Ali M.T., Tan T.C., et al. Left Ventricular Global Longitudinal Strain in HER-2 + Breast Cancer Patients Treated with Anthracyclines and Trastuzumab Who Develop Cardiotoxicity Is Associated with Subsequent Recovery of Left Ventricular Ejection Fraction. Echocardiography, 2016, vol. 33, no. 4. pp. 519-26. doi:10.1111/echo.13168.</mixed-citation><mixed-citation xml:lang="en">Fei H.W., Ali M.T., Tan T.C., et al. Left Ventricular Global Longitudinal Strain in HER-2 + Breast Cancer Patients Treated with Anthracyclines and Trastuzumab Who Develop Cardiotoxicity Is Associated with Subsequent Recovery of Left Ventricular Ejection Fraction. Echocardiography, 2016, vol. 33, no. 4. pp. 519-26. doi:10.1111/echo.13168.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Calle M.C., Sandhu N.P., Xia H., et al. Two-dimensional speckle tracking echocardiography predicts early subclinical cardiotoxicity associated with anthracycline-trastuzumab chemotherapy in patients with breast cancer. BMC Cancer, 2018, vol. 18. doi:10.1186/ s12885-018-4935-z.</mixed-citation><mixed-citation xml:lang="en">Calle M.C., Sandhu N.P., Xia H., et al. Two-dimensional speckle tracking echocardiography predicts early subclinical cardiotoxicity associated with anthracycline-trastuzumab chemotherapy in patients with breast cancer. BMC Cancer, 2018, vol. 18. doi:10.1186/ s12885-018-4935-z.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Tu C., Shen H., Liu R., Wang X., Li X., Yuan X., Chen Q., Wang Y., Ran Z., Lan X., Zhang X., Lin M., Zhang J. Myocardial extracellular volume derived from contrast-enhanced chest computed tomography for longitudinal evaluation of cardiotoxicity in patients with breast cancer treated with anthracyclines. Insights Imaging, 2022, vol. 13(1), pp. 85. doi: 10.1186/s13244-022-01224-5.</mixed-citation><mixed-citation xml:lang="en">Tu C., Shen H., Liu R., Wang X., Li X., Yuan X., Chen Q., Wang Y., Ran Z., Lan X., Zhang X., Lin M., Zhang J. Myocardial extracellular volume derived from contrast-enhanced chest computed tomography for longitudinal evaluation of cardiotoxicity in patients with breast cancer treated with anthracyclines. Insights Imaging, 2022, vol. 13(1), pp. 85. doi: 10.1186/s13244-022-01224-5.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Souza C.A., Simões R., Borges K.B.G., Oliveira A.N., Zogeib J.B., Alves B., Malachias MVB, Drummond-Lage A.P., Rezende B.A. Arterial Stiffness Use for Early Monitoring of Cardiovascular Adverse Events due to Anthracycline Chemotherapy in Breast Cancer Patients. A Pilot Study. Arq Bras Cardiol, 2018, vol. 111, no. 5, pp.721-728. doi: 10.5935/abc.20180168.</mixed-citation><mixed-citation xml:lang="en">Souza C.A., Simões R., Borges K.B.G., Oliveira A.N., Zogeib J.B., Alves B., Malachias MVB, Drummond-Lage A.P., Rezende B.A. Arterial Stiffness Use for Early Monitoring of Cardiovascular Adverse Events due to Anthracycline Chemotherapy in Breast Cancer Patients. A Pilot Study. Arq Bras Cardiol, 2018, vol. 111, no. 5, pp.721-728. doi: 10.5935/abc.20180168.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Parr SK, Liang J, Schadler KL, Gilchrist SC, Steele CC, Ade CJ. Anticancer Therapy-Related Increases in Arterial Stiffness: A Systematic Review and Meta-Analysis. J Am Heart Assoc, 2020, vol. 9(14), e015598. doi: 10.1161/JAHA.119.015598.</mixed-citation><mixed-citation xml:lang="en">Parr SK, Liang J, Schadler KL, Gilchrist SC, Steele CC, Ade CJ. Anticancer Therapy-Related Increases in Arterial Stiffness: A Systematic Review and Meta-Analysis. J Am Heart Assoc, 2020, vol. 9(14), e015598. doi: 10.1161/JAHA.119.015598.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
