emcardioНеотложная кардиология и кардиоваскулярные рискиEmergency Cardiology and Cardiovascular Risks journal2616-633XБелорусский государственный медицинский университет10.51922/2616-633X.2023.7.1.1868emcardio-59Research ArticleОбзоры и лекцииReviews and lecturesОстеосаркопения и артериальная гипертензия: современный взгляд на проблемуOsteosarcopenia and arterial hypertension: current approaches to the problemАнтюхК. Ю.AntyukhK.

Минск

Minsk

gladun-karina@mail.ruГригоренкоЕ. А.GrigorenkoE.

Минск

Minsk

ШептулинаА. Ф.SheptulinaА.

Москва

Moscow

ДрапкинаО. М.DrapkinaO.

Москва

Moscow

МитьковскаяН. П.MitkovskayaN.

Минск

Minsk

Республиканский научно-практический центр «Кардиология»Republican Scientific and Practical Center of CardiologyРеспубликанский научно-практический центр «Кардиология»; Белорусский государственный медицинский университетRepublican Scientific and Practical Center of Cardiology; Belarusian State Medical UniversityФедеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр терапии и профилактической медицины» Министерства здравоохранения Российской Федерации; Федеральное государственное бюджетное образовательное учреждение высшего образования «Московский государственный медико-стоматологический университет имени А.И. Евдокимова» Министерства здравоохранения Российской ФедерацииFederal State Budgetary Institution “National Medical Research Center for Therapy and Preventive Medicine” of the Ministry of Healthсare of the Russian Federation; Federal State Budgetary Educational Institution of Higher Education “A.I. Yevdokimov Moscow State University of Medicine and Dentistry” of the Ministry of Healthcare of the Russian Federation2023200620257118681875Copyright © Антюх К.Ю., Григоренко Е.А., Шептулина А.Ф., Драпкина О.М., Митьковская Н.П., 20252025Антюх К.Ю., Григоренко Е.А., Шептулина А.Ф., Драпкина О.М., Митьковская Н.П.Antyukh K., Grigorenko E., Sheptulina А., Drapkina O., Mitkovskaya N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://emcardio.bsmu.by/jour/article/view/59

Остеосаркопения характеризуется сочетанием низкой мышечной массы (саркопении) и сниженной минеральной плотности костной ткани (остеопении/остеопороза). Результаты научных исследований, проведенных в последние годы, свидетельствуют о наличии взаимосвязи между артериальной гипертензией, нарушениями метаболизма костной ткани и/или саркопенией. В частности, известно, что в развитии и прогрессировании как артериальной гипертензии, так и саркопении принимают участие системное воспаление, оксидативный стресс, инсулинорезистентность. Те же факторы могут играть роль в патогенезе остеопении и остеопороза, а патологические механизмы, лежащие в основе повышения артериального давления, как показано в экспериментальных и клинических исследованиях, способны дополнительно влиять на снижение минеральной плотности костной ткани. В данном обзоре изложены современные представления о диагностике, эпидемиологии, этиологии, а также возможных механизмах патогенеза остеосаркопении у пациентов с артериальной гипертензией.

Osteosarcopenia is characterized by a combination of low muscle mass (sarcopenia) and reduced bone mineral density (osteopenia/ osteoporosis). The results of scientific studies conducted in recent years indicate the existence of a relationship between arterial hypertension, disorders of bone metabolism and / or sarcopenia. In particular, it is known that systemic inflammation, oxidative stress, and insulin resistance are involved in the development and progression of both arterial hypertension and sarcopenia. The same factors may play a role in the pathogenesis of osteopenia and osteoporosis, and the pathological mechanisms underlying the increase in blood pressure, as shown in experimental and clinical studies, can additionally influence the decrease in bone mineral density. This review outlines the current understanding of the diagnosis, epidemiology, etiology, and possible mechanisms of the pathogenesis of osteosarcopenia in patients with arterial hypertension.

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The authors declare that there are no conflicts of interest present.