emcardioНеотложная кардиология и кардиоваскулярные рискиEmergency Cardiology and Cardiovascular Risks journal2616-633XБелорусский государственный медицинский университет10.51922/2616-633X.2024.8.1.2181emcardio-52Research ArticleРецензии на лекцииReviews of the lecturesВозможности практического применения переносчиков кислорода на основе полимеризованного гемоглобина в органной трансплантацииPractical applications of hemoglobin-based oxygen carriers in organ transplantationВанЦиньциWangQinqi

Циньци Ван

130022; Чанчунь; 100176; Пекин

Qinqi Wang

130022; Changchun; 100176; Beijing

ШестаковаЛ. Г.ShestakovaL.

Минск

Liana Shestakova

220036; 110 B R.Luxemburg Str.; Minsk

shestakova@hotmail.comКолесникИ. А.KolesnikI.

Минск

Irina Kolesnik

220072; 13 Surganov Str.; Minsk

ДинЦзяньсюньDingJianxun

Цзяньсюнь Дин

130022; Чанчунь

Jianxun Ding

130022; Changchun

СуньТяньмэньSunTianmeng

Тяньмэнь Сунь

130061; Чанчунь

Tianmeng Sun

130061; Changchun

ЛиВэньлянLiWenliang

Вэньлян Ли

130022; Чанчунь; 100176; Пекин

Wenliang Li

130022; Changchun; 100176; Beijing

ОстровскийЮ. П.OstrovskyYou.

Минск

Youry Ostrovsky

220036; 110 B R.Luxemburg Str.; Minsk

АлексеевЮ. Г.AliakseyeuYu.

Минск

Yury Aliakseyeu

Minsk

Школа химической и экологической инженерии, Чанчуньский университет науки и технологий; Редфарм (Пекин) Биотех ЛимитедSchool of Chemical and Environmental Engineering, Changchun University of Science and Technology; Redpharm (Beijing) Biotech LimitedГосударственное учреждение «Республиканский научно-практический центр «Кардиология»Belarusian Republican Scientific and Practical Center of CardiologyГосударственное научное учреждение «Институт физико-органической химии Национальной академии наук Беларуси»Institute of Physical Organic Chemistry of National Academy of Sciences of BelarusГлавная лаборатория полимерных экоматериалов, Чанчуньский институт прикладной химии, Китайская академия наукKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of SciencesГлавная лаборатория регенерации и трансплантации органов Министерства образования, Институт иммунологии, Первая больница, Университет ЦзилиньKey Laboratory of Organ Regeneration and Transplantation of Ministry of Education, Institute of Immunology, The First Hospital, Jilin UniversityОбщество с ограниченной ответственностью «Инновационный международный центр научно-образовательного и коммерческого сотрудничества «Дело»Belarusian “Innovative International Center for Scientific, Educational and Commercial Cooperation “Delo”2024200620258121812186Copyright © Ван Ц., Шестакова Л.Г., Колесник И.А., Дин Ц., Сунь Т., Ли В., Островский Ю.П., Алексеев Ю.Г., 20252025Ван Ц., Шестакова Л.Г., Колесник И.А., Дин Ц., Сунь Т., Ли В., Островский Ю.П., Алексеев Ю.Г.Wang Q., Shestakova L., Kolesnik I., Ding J., Sun T., Li W., Ostrovsky Y., Aliakseyeu Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://emcardio.bsmu.by/jour/article/view/52

   В последние годы большое внимание уделяется кислородно-транспортным свойствам переносчиков кислорода на основе гемоглобина (HBOCs), которые способны связывать кислород в легких и доставлять его к органам и тканям через артериальную кровь для обеспечения тканевого дыхания. Исследования показали, что HBOCs, характеризующиеся низкой иммуногенностью, малым риском гемолитической реакции, низкой вязкостью и улучшенным диффузионным переносом кислорода, могут показать хорошие результаты при клиническом применении в области трансплантации органов. Ранние поколения HBOCs имели короткое время внутрисосудистой циркуляции из-за нестойкости тетрамера гемоглобина, вызывали побочные вазоспастические эффекты и токсичность, обусловленную свободным гемоглобином. Полимеризация молекул гемоглобина стабилизировала тетрамер путем сшивания димеров внеклеточного гемоглобина, тем самым минимизируя экстравазацию и продлевая период внутрисосудистой циркуляции. Полимеризация глютаральдегидом считается ключевым фактором в смягчении вазоконстрикторных эффектов внеклеточного гемоглобина.

   Цель данной статьи – дать подробный обзор современного состояния исследований и применения переносчиков кислорода на основе гемоглобина (HBOCs) в трансплантации органов, а также заглянуть в будущее их использования в этой области.

   In recent years, much attention has been paid to the excellent oxygen transport properties of Hemoglobin-based oxygen carriers (HBOCs), which deliver oxygen to organs and tissues via arterial blood by binding oxygen and carbon dioxide via venous blood back to the lungs for respiratory elimination from the body. Studies have shown that HBOCs, which are characterized by low immunogenicity, little risk of hemolytic reaction, low viscosity, and enhanced diffusive oxygen transport, can show excellent results in clinical applications in the field of organ transplantation. Early HBOCs generations had a short intravascular circulation life-time, could cause vasospastic and toxic side effects induced by free hemoglobin circulation. Polymerization of hemoglobin molecules significantly increased the size of acellular hemoglobin, thus minimizing the extravasation and prolonging their half-life in intravascular circulation, and was considered to be the key factor in mitigating the vasoconstriction effects.

   The aim of this paper is to provide an in-depth review of the current status of research and application of HBOCs in organ transplantation, as well as to look forward to their future application in this field.

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The authors declare that there are no conflicts of interest present.