emcardioНеотложная кардиология и кардиоваскулярные рискиEmergency Cardiology and Cardiovascular Risks journal2616-633XБелорусский государственный медицинский университет10.51922/2616-633X.2024.8.2.2282emcardio-36Research ArticleОригинальные научные публикацииOriginal Scientific ResearchКишечная микрофлора нормотензивных пациентов с висцеральным ожирениемIntestinal microflora of normotensive patients with visceral obesityСухоцкаяЕ. А.SukhotskayaE.

Минск

 Minsk 

МалиновскаяЮ. В.MalinovskayaY.

Минск

 Minsk 

СемижонП. А.SemizhonP.

Минск

 Minsk 

ЧерневскаяМ. В.ChernevskayaM.

Минск

 Minsk 

БельскаяМ. И.BelskayaM.

Минск

 Minsk 

ПавловаО. С.PavlovaO.

Минск

 Minsk 

Научно-исследовательский институт гигиены, токсикологии, эпидемиологии, вирусологии и микробиологии государственного учреждения «Республиканский центр гигиены, эпидемиологии и общественного здоровья»Scientific Research Institute of Hygiene, Toxicology, Epidemiology, Virology and Microbiology of the state institution “Republican Center for Hygiene, Epidemiology and Public Health”Государственное учреждение «Республиканский научно-практический центр «Кардиология»State Institution “Republican Scientific and Practical Center “Cardiology”202420062025822282–2286Copyright © Сухоцкая Е.А., Малиновская Ю.В., Семижон П.А., Черневская М.В., Бельская М.И., Павлова О.С., 20252025Сухоцкая Е.А., Малиновская Ю.В., Семижон П.А., Черневская М.В., Бельская М.И., Павлова О.С.Sukhotskaya E., Malinovskaya Y., Semizhon P., Chernevskaya M., Belskaya M., Pavlova O.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://emcardio.bsmu.by/jour/article/view/36

Получены изменения количественного состава определенных представителей кишечной микрофлоры, характерные для нормотензивных пациентов с висцеральным ожирением в сравнении с нормотензивными пациентами без висцерального ожирения – снижение пула комменсальных бактерий Faecalibacterium spp. (10,51 ± 1,13 vs. 9,5 ± 1,14, p = 0,020), Lactobacillus spp. (9,17 ± 1,74 vs. 8,00 ± 2,52, p = 0,025), Bacteroides spp. (9,02 ± 0,76 vs. 8,46 ± 0,47, p = 0,027), Fusobacterium spp. (13,4 ± 1,01 vs. 12,03 ± 0,92, p < 0,001), Bifidobacterium spp. (7,31 ± 1,16 vs. 5,95 ± 1,82, p = 0,028) соответственно. Количественное содержание представителей условно-патогенной микрофлоры кишечника Streprococcus spp. (6,31 ± 0,79 vs. 5,87 ± 0,78, p = 0,032) и Staphylococcus spp. (6,67 ± 1,23 vs. 5,98 ± 0,98, p = 0,036) было увеличено у пациентов с висцеральным ожирением в сравнении с группой пациентов без висцерального ожирения.

Weobtained changed readings in the quantitative composition of certain representatives of the intestinal microflora characteristic of normotensive patients with visceral obesity in comparison with normotensive patients without visceral obesity. They included a decreased pool of commensal bacteria Faecalibacterium spp. (10.51 ± 1.13 vs. 9.5 ± 1.14, p = 0.020), Lactobacillus spp. (9.17 ± 1.74 vs. 8.00 ± 2.52, p = 0.025), Bacteroides spp. (9.02 ± 0.76 vs. 8.46 ± 0.47, p = 0.027), Fusobacterium spp. (13.4 ± 1.01 vs. 12.03 ± 0.92, p < 0,001), Bifidobacterium spp. (7.31 ± 1.16 vs. 5.95 ± 1.82, p = 0.028) respectively. Quantitative content of representatives of opportunistic intestinal microflora Streprococcus spp. (6.31 ± 0.79 vs. 5.87 ± 0.78, p = 0.032) and Staphylococcus spp. (6.67 ± 1.23 vs. 5.98 ± 0.98, p = 0.036) was increased in patients with visceral obesity compared to the group of patients without visceral obesity.

visceral obesityintestinal microfloradysbiosisquantitative PCRFaecalibacterium spp.Lactobacillus spp.Bacteroides sppFusobacterium spp.Bifidobacterium spp.Streprococcus spp.Staphylococcus sppvisceral obesityintestinal microfloradysbiosisquantitative PCRFaecalibacterium spp.Lactobacillus spp.Bacteroides sppFusobacterium spp.Bifidobacterium spp.Streprococcus spp.Staphylococcus sppReferencesObesity and overweight. Bulletin World Health Organization. 2021.Obesity and overweight. Bulletin World Health Organization. 2021.Vasyukova O.V. Federal clinical guidelines for the diagnosis and treatment of obesity in children and adolescents. M.: Rossijskaya associaciya endokrinologov, 2013, pp. 5-8. (in Russian).Vasyukova O.V. Federal clinical guidelines for the diagnosis and treatment of obesity in children and adolescents. M.: Rossijskaya associaciya endokrinologov, 2013, pp. 5-8. (in Russian).Borga M., West J., Bell J.D., et al. Advanced body composition assessment: From body mass index to body composition profiling. J Investig Med, 2018, vol. 66 (5), pp. 1-9. doi: 10.1136/jim-2018-000722.Borga M., West J., Bell J.D., et al. Advanced body composition assessment: From body mass index to body composition profiling. J Investig Med, 2018, vol. 66 (5), pp. 1-9. doi: 10.1136/jim-2018-000722.Simoni P., Guglielmi R., Aparisi Gomez M.P. Imaging of body composition in children. Quant Imaging Med Surg, 2020, vol. 10 (8), pp. 1661-1671. doi: 10.21037/qims.2020.04.06.Simoni P., Guglielmi R., Aparisi Gomez M.P. Imaging of body composition in children. Quant Imaging Med Surg, 2020, vol. 10 (8), pp. 1661-1671. doi: 10.21037/qims.2020.04.06.Kotrova A.D., Shishkin A. N., Ermolenko E. I., Sarajkina D.A., et al. Gut microbiota in arterial hypertension. Arterialnaya gipertenziya, 2020, vol. 26, pp. 620-628. (in Russian).Kotrova A.D., Shishkin A. N., Ermolenko E. I., Sarajkina D.A., et al. Gut microbiota in arterial hypertension. Arterialnaya gipertenziya, 2020, vol. 26, pp. 620-628. (in Russian).Chervinec V. M., Chervinec Y.V., Belyaeva E.A., Petrova O.A., et al. Metabolic activity of highly antagonistic lactobacilli strains from healthy humans. Zhurnal mikrobiologii, epidemiologii i immunobiologii, 2018, vol. 95 (4), pp. 11-17. (in Russian).Chervinec V. M., Chervinec Y.V., Belyaeva E.A., Petrova O.A., et al. Metabolic activity of highly antagonistic lactobacilli strains from healthy humans. Zhurnal mikrobiologii, epidemiologii i immunobiologii, 2018, vol. 95 (4), pp. 11-17. (in Russian).Chen L., Luo Y., Wang H., et al. Effects of glucose and starch on lactate roduction by newly isolated streptococcus bovis S1 from saanen goats. Appl Environ Microbiol. 2016, vol. 82 (19), pp. 5982–5989. doi: 10.1128/AEM.01994-16.Chen L., Luo Y., Wang H., et al. Effects of glucose and starch on lactate roduction by newly isolated streptococcus bovis S1 from saanen goats. Appl Environ Microbiol. 2016, vol. 82 (19), pp. 5982–5989. doi: 10.1128/AEM.01994-16.Shariq O.A., McKenzie T.J. Obesity-related hypertension: a review of pathophysiology, management, and the role of metabolic surgery. Gland Surg, 2020, vol. 9 (1), pp. 80-93. doi: 10.21037/gs.2019.12.03.Shariq O.A., McKenzie T.J. Obesity-related hypertension: a review of pathophysiology, management, and the role of metabolic surgery. Gland Surg, 2020, vol. 9 (1), pp. 80-93. doi: 10.21037/gs.2019.12.03.Cuevas-Sierra A., Ramos-Lopez O., Riezu-Boj J.I., Milagro F.I., Martinez J.A. Diet, Gut Microbiota, and Obesity: Links with Host Genetics and Epigenetics and Potential Applications. Adv Nutr, 2019, vol. 10 (suppl_1), pp. S17-S30. doi: 10.1093/advances/nmy078.Cuevas-Sierra A., Ramos-Lopez O., Riezu-Boj J.I., Milagro F.I., Martinez J.A. Diet, Gut Microbiota, and Obesity: Links with Host Genetics and Epigenetics and Potential Applications. Adv Nutr, 2019, vol. 10 (suppl_1), pp. S17-S30. doi: 10.1093/advances/nmy078.Chervinec V.M., Chervinec Y.V., Serova N.E., et al. Microbiome of the oral cavity and intestine in patients with arterial hypertension. Bulletin of the Orenburg Scientific Center of the Ural Branch of the Russian Academy of Sciences, 2019, vol. 3, pp. 27. (in Russian).Chervinec V.M., Chervinec Y.V., Serova N.E., et al. Microbiome of the oral cavity and intestine in patients with arterial hypertension. Bulletin of the Orenburg Scientific Center of the Ural Branch of the Russian Academy of Sciences, 2019, vol. 3, pp. 27. (in Russian)..Chambers E.S., Preston T., Frost G., Morrison D.J. Role of gut microbiota-generated short-chain fatty acids in metabolic and cardiovascular health. Curr Nutr Rep, 2018, vol. 7 (4), pp. 198-206. doi: 10.1007/s13668-018-0248-8..Chambers E.S., Preston T., Frost G., Morrison D.J. Role of gut microbiota-generated short-chain fatty acids in metabolic and cardiovascular health. Curr Nutr Rep, 2018, vol. 7 (4), pp. 198-206. doi: 10.1007/s13668-018-0248-8..Kim S., Goel R., Kumar A. et al. Imbalance of gut microbiome and intestinal epithelial barrier dysfunction in patients with high blood pressure. Clin. Sci. (Lond), 2018, vol. 132 (6), p. 701-718. doi: 10.1042/CS20180087..Kim S., Goel R., Kumar A. et al. Imbalance of gut microbiome and intestinal epithelial barrier dysfunction in patients with high blood pressure. Clin. Sci. (Lond), 2018, vol. 132 (6), p. 701-718. doi: 10.1042/CS20180087.

The authors declare that there are no conflicts of interest present.