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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">emcardio</journal-id><journal-title-group><journal-title xml:lang="ru">Неотложная кардиология и кардиоваскулярные риски</journal-title><trans-title-group xml:lang="en"><trans-title>Emergency Cardiology and Cardiovascular Risks journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2616-633X</issn><publisher><publisher-name>Белорусский государственный медицинский университет</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.51922/2616-633X.2025.9.2.2642</article-id><article-id custom-type="elpub" pub-id-type="custom">emcardio-326</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Оригинальные научные публикации</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Original Scientific Research</subject></subj-group></article-categories><title-group><article-title>Факторы риска развития ишемически-реперфузионных повреждений миокарда при коронарном шунтировании</article-title><trans-title-group xml:lang="en"><trans-title>Risk factors of ischemic-reperfusion myocardial injury during coronary artery bypass grafting</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шибеко</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Shybeka</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Минск</p></bio><bio xml:lang="en"><p>Minsk</p></bio><email xlink:type="simple">shibekonat@yandex.by</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гелис</surname><given-names>Л. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Gelis</surname><given-names>L. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Минск</p></bio><bio xml:lang="en"><p>Minsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Русак</surname><given-names>Т. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Rusak</surname><given-names>T. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Минск</p></bio><bio xml:lang="en"><p>Minsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тарасик</surname><given-names>Е. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Tarasik</surname><given-names>E. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Минск</p></bio><bio xml:lang="en"><p>Minsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Республиканский научно-практический центр «Кардиология»</institution></aff><aff xml:lang="en"><institution>Republican Scientific and Practical Center of Cardiology</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>25</day><month>01</month><year>2026</year></pub-date><volume>9</volume><issue>2</issue><fpage>2642</fpage><lpage>2651</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Шибеко Н.А., Гелис Л.Г., Русак Т.В., Тарасик Е.С., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Шибеко Н.А., Гелис Л.Г., Русак Т.В., Тарасик Е.С.</copyright-holder><copyright-holder xml:lang="en">Shybeka N.A., Gelis L.G., Rusak T.V., Tarasik E.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://emcardio.bsmu.by/jour/article/view/326">https://emcardio.bsmu.by/jour/article/view/326</self-uri><abstract><p>Современная кардиохирургия достигла значительных успехов в лечении ишемической болезни сердца. Однако, несмотря на высокую эффективность лечения, интервенционные технологии несут в себе потенциальную опасность развития осложнений. Немаловажную роль при этом играют реперфузионные повреждения.</p><sec><title>Цель исследования</title><p>Цель исследования: определить факторы риска, влияющие на развитие ишемически-реперфузионных повреждений миокарда при кардиохирургических вмешательствах у пациентов с ишемической болезнью сердца.</p></sec><sec><title>Материал и методы</title><p>Материал и методы: проведено проспективное исследование, в которое включено 162 пациента, которым было выполнено коронарное шунтирование на «работающем сердце» – 25 пациентов (15,4%), коронарное шунтирование в условиях искусственного кровообращения (ИК) – 81 пациент (50%) и 56 пациентам (34,6%) в дополнение к реваскуляризации миокарда выполнена пластика или протезирование митрального и/или трикуспидального клапанов. Ишемически-реперфузионные повреждения встречались у 58 (35,8%) пациентов. Всем пациентам проводились эхокардиография, коронароангиография, магнитно-резонансная томография, а также выполнялся комплекс клинико-лабораторных исследований, включающий маркеры кардиоваскулярного риска.</p></sec><sec><title>Результаты</title><p>Результаты: при проведении исследования выявлено, что факторами риска, влияющими на развитие ишемически-реперфузионных повреждений миокарда, как при кардиохирургических вмешательствах в условиях искусственного кровообращения, так и при коронарном шунтировании на работающем сердце, являются индекс массы миокарда левого желудочка (r = 0,75; p = 0,01; r = 0,68; р &lt; 0,05, соответственно), количество баллов по шкале SYNTAX Score (r = 0,7; p = 0,01; r = 0,56; р &lt; 0,05, соответственно), а также исходный уровень высокочувствительного тропонина I (r = 0,88; p = 0,001; r = 0,71; p = 0,01;соответственно). Интраоперационными факторами риска развития реперфузионных повреждений миокарда служат время ишемии миокарда (r = 0,65, p &lt; 0,05) и длительность искусственного кровообращения (r = 0,72; p = 0,01) при кардиохирургических вмешательствах в условиях искусственного кровообращения.</p><p>Таким образом, установлен ряд факторов риска, влияющих на развитие ишемически-реперфузионных нарушений миокарда при кардиохирургических вмешательствах.</p></sec></abstract><trans-abstract xml:lang="en"><p>Modern cardiac surgery has made significant advances in the treatment of coronary artery disease. Despite the high effectiveness of treatment, interventional techniques, however, suggest a potential risk of complications, reperfusion injury playing a significant role in this.</p><p>The aim of the study was to identify risk factors influencing the development of ischemia-reperfusion myocardial injury during cardiac surgery in patients with coronary heart disease.</p><sec><title>Materials and Methods</title><p>Materials and Methods. This prospective study included 162 patients, of whom 25 patients (15.4%) underwent off-pump coronary artery bypass grafting, 81 patients (50%) survived on-pump coronary artery bypass grafting and 56 patients (34.6%) underwent mitral and/or tricuspid valve repair or replacement in addition to myocardial revascularization. Ischemia-reperfusion injury was observed in 58 (35.8%) patients. All patients underwent echocardiography, coronary angiography, magnetic resonance imaging and a comprehensive clinical and laboratory analysis, including markers of cardiovascular risk.</p></sec><sec><title>Results</title><p>Results: The study revealed that risk factors influencing the development of ischemia-reperfusion myocardial injury, both during cardiac surgery using artificial circulation and during coronary artery bypass grafting on a beating heart, are the left ventricular myocardial mass index (r = 0.75; p = 0.01; r = 0.68; p &lt; 0.05, respectively), points on the SYNTAX Score scale (r = 0.7; p = 0.01; r = 0.56; p &lt; 0.05, respectively), as well as the initial level of high-sensitivity troponin I (r = 0.88; p = 0.001; r = 0.71; p = 0.01; respectively). Intraoperative risk factors for the development of myocardial reperfusion injury include the duration of myocardial ischemia (r = 0.65, p &lt; 0.05) and the duration of artificial circulation (r = 0.72; p = 0.01) during cardiac surgery using artificial circulation.</p><p>Thus, a number of risk factors influencing the development of myocardial ischemia-reperfusion disorders during cardiac surgery were established.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>ишемическая болезнь сердца</kwd><kwd>коронарное шунтирование</kwd><kwd>искусственное кровообращение</kwd><kwd>ишемически-реперфузионные поврждения миокарда</kwd></kwd-group><kwd-group xml:lang="en"><kwd>ischemic heart disease</kwd><kwd>coronary artery bypass grafting</kwd><kwd>artificial circulation</kwd><kwd>ischemia-reperfusion myocardial injury</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Bokerija, L.A., Gudkova R.G. 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