emcardioНеотложная кардиология и кардиоваскулярные рискиEmergency Cardiology and Cardiovascular Risks journal2616-633XБелорусский государственный медицинский университет10.51922/2616-633X.2023.7.2.1928emcardio-30Research ArticleОригинальные научные публикацииOriginal Scientific ResearchАссоциация полиморфизма генов системы гемостаза с клинико-лабораторными показателями у пациентов с инфарктом миокардаAssociation of the hemostasis gene polymorphisms with clinical and laboratory findings in patients with myocardial infarctionКоролеваТ. С.KorolevaT. S.

Минск

Minsk

koroleva.tosya@mail.ruБулгакА. Г.BulgakA. G.

Минск

Minsk

МоссэИ. Б.MosseI. B.

Минск

Minsk

СедлярН. Г.SedlyarN. G.

Минск

Minsk

ЗотоваО. В.ZotovaO. V.

Минск

Minsk

Государственное учреждение «Республиканский научно-практический центр «Кардиология»Republican Scientific and Practical Center “Cardiology”Государственное учреждение образования «Белорусская медицинская академия последипломного образования»Belarusian Medical Academy of Postgraduate EducationГосударственной научное учреждение «Институт генетики и цитологии Национальной академии наук Беларуси»The Institute of Genetics and Cytology of the National Academy of Sciences of Belarus2023190620257219281936Copyright © Королева Т.С., Булгак А.Г., Моссэ И.Б., Седляр Н.Г., Зотова О.В., 20252025Королева Т.С., Булгак А.Г., Моссэ И.Б., Седляр Н.Г., Зотова О.В.Koroleva T.S., Bulgak A.G., Mosse I.B., Sedlyar N.G., Zotova O.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://emcardio.bsmu.by/jour/article/view/30

Оценена взаимосвязь полиморфных вариантов генов FGA, FGG, F2, F5, F11, F13, PAI-1 и GP6 с данными клинико-инструментальных и лабораторных исследований среди пациентов с инфарктом миокарда из Республики Беларусь. Показано, что для пациентов с инфарктом миокарда имеются статистически значимые ассоциации между полиморфными вариантами генов F11 (rs2289252 и rs2036914), F13 (rs5985), F5 (rs6025), PAI-1 (rs1799889), FGG (rs2066865) и рядом лабораторных значений и функциональных показателей миокарда. Совокупный анализ как генетической компоненты (полиморфизм ДНК), так и результатов динамичного наблюдения пациента в стационаре, способен корректно оценить риски возникновения и нежелательного прогрессирования заболеваний, включая инфаркт миокарда.

The article presents the analysis of the association between polymorphic variants of the FGA, FGG, F2, F5, F11, F13, PAI-1, and GP6 genes and clinical, instrumental, and laboratory data in patients with myocardial infarction from the Republic of Belarus. It has been demonstrated that in patients with myocardial infarction, there exist statistically significant correlations between polymorphic variants of the genes F11 (rs2289252 and rs2036914), F13 (rs5985), F5 (rs6025), PAI-1 (rs1799889), FGG (rs2066865), and a variety of laboratory values and functional indicators of the myocardium. A comprehensive analysis of the genetic component (DNA polymorphism) and the outcomes of dynamic follow-up of the patient in hospital enable clinicians to accurately assess potential hazards of the occurrence and unfavorable progression of a number of diseases including myocardial infarction.

инфаркт миокардаполиморфизмлабораторные исследованияфункциональные показатели миокардаассоциацияmyocardial infarctionpolymorphismlaboratory testsmyocardial function indicatorsassociationReferencesPavlova O., Patseyev A., Stelmashok V. Country report Belarus – February 2017. 2017, 11 s.Pavlova O., Patseyev A., Stelmashok V. Country report Belarus – February 2017. 2017, 11 s.Hartiala J.A., Han Y, Jia Q., Hilser J.R., Huang P., Gukasyan J., Schwartzman W.S., Cai Z., Biswas S., Trégouët D.A., Smith N.L. [et al.] Genome-wide analysis identifies novel susceptibility loci for myocardial infarction. Eur. Heart J, 2021, vol. 42, no. 9, pp. 919-933. doi: 10.1093/eurheartj/ehaa1040.Hartiala J.A., Han Y, Jia Q., Hilser J.R., Huang P., Gukasyan J., Schwartzman W.S., Cai Z., Biswas S., Trégouët D.A., Smith N.L. [et al.] Genome-wide analysis identifies novel susceptibility loci for myocardial infarction. Eur. Heart J, 2021, vol. 42, no. 9, pp. 919-933. doi: 10.1093/eurheartj/ehaa1040.Sakaue S., Kanai M., Tanigawa Y., Karjalainen J., Kurki M., Koshiba S., Narita A., Konuma T., Yamamoto K., Akiyama M., Ishigaki K., Suzuki A. [et al.] A cross-population atlas of genetic associations for 220 human phenotypes. Nat. Genet, 2021, vol. 53, no. 10, pp. 1415-1424. doi: 10.1038/s41588-021-00931-x.Sakaue S., Kanai M., Tanigawa Y., Karjalainen J., Kurki M., Koshiba S., Narita A., Konuma T., Yamamoto K., Akiyama M., Ishigaki K., Suzuki A. [et al.] A cross-population atlas of genetic associations for 220 human phenotypes. Nat. Genet, 2021, vol. 53, no. 10, pp. 1415-1424. doi: 10.1038/s41588-021-00931-x.Dönertaş H.M., Fabian D.K., Valenzuela MF, Partridge L, Thornton JM. Common genetic associations between age-related diseases. Nat Aging, 2021, vol. 1, no. 4, pp. 400-412. doi: 10.1038/s43587-021-00051-5.Dönertaş H.M., Fabian D.K., Valenzuela MF, Partridge L, Thornton JM. Common genetic associations between age-related diseases. Nat Aging, 2021, vol. 1, no. 4, pp. 400-412. doi: 10.1038/s43587-021-00051-5.Sedlyar N.G., Gonchar A.L., Ameljanovich M.D., Mosset I.B. Rol’ geneticheskih faktorov v predraspolozhennosti k nevynashivaniyu beremennosti [Role of genetic factors in predisposition to pregnancy loss]. Molekulyarnaya i prikladnaya genetika. 2016, vol. 20, pp. 87-95. (in Russian).Sedlyar N.G., Gonchar A.L., Ameljanovich M.D., Mosset I.B. Rol’ geneticheskih faktorov v predraspolozhennosti k nevynashivaniyu beremennosti [Role of genetic factors in predisposition to pregnancy loss]. Molekulyarnaya i prikladnaya genetika. 2016, vol. 20, pp. 87-95. (in Russian).Sedlyar N.G., Mosse I.B., Kundas L.A., Gonchar A.L., Amel’yanovich M.D. Ocenka riska nevynashiva niya beremennosti na osnove molekulyarno-geneticheskogo analiza [Assessment of a miscarriage risk based on the molecular genetic analysis]. Molekulyarnaya i prikladnaya genetika. 2020, vol. 28, pp. 91-103. (in Russian).Sedlyar N.G., Mosse I.B., Kundas L.A., Gonchar A.L., Amel’yanovich M.D. Ocenka riska nevynashiva niya beremennosti na osnove molekulyarno-geneticheskogo analiza [Assessment of a miscarriage risk based on the molecular genetic analysis]. Molekulyarnaya i prikladnaya genetika. 2020, vol. 28, pp. 91-103. (in Russian).Mosse I.B., Zotova O.V., Koroleva T.S., Nikolaeva N.V., Gonchar A.L. Rol’ geneticheskogo polimorfizma v razvitii infarkta miokarda sredi muzhchin iz Respubliki Belarus’ [The role of genetic polymorphism in the development of myocardial infarction in men from the Republic of Belarus]. Mediko-biologicheskie problemy zhiznedeyatel’nosti, 2021, no. 1, pp. 102-112. (in Russian).Mosse I.B., Zotova O.V., Koroleva T.S., Nikolaeva N.V., Gonchar A.L. Rol’ geneticheskogo polimorfizma v razvitii infarkta miokarda sredi muzhchin iz Respubliki Belarus’ [The role of genetic polymorphism in the development of myocardial infarction in men from the Republic of Belarus]. Mediko-biologicheskie problemy zhiznedeyatel’nosti, 2021, no. 1, pp. 102-112. (in Russian).Elbaz A., Poirier O., Canaple S., Chédru F., Cambien F., Amarenco P. The association between the Val34Leu polymorphism in the factor XIII gene and brain infarction. Blood, 2000, vol. 95, no. 2, pp. 586-591.Elbaz A., Poirier O., Canaple S., Chédru F., Cambien F., Amarenco P. The association between the Val34Leu polymorphism in the factor XIII gene and brain infarction. Blood, 2000, vol. 95, no. 2, pp. 586-591.Mannila M.N., Eriksson P., Ericsson C.G., Hamsten A., Silveira A. Epistatic and pleiotropic effects of polymorphisms in the fibrinogen and coagulation factor XIII genes on plasma fibrinogen concentration, fibrin gel structure and risk of myocardial infarction. Thromb Haemost, 2006, vol. 95, no. 3, pp.420-427. doi: 10.1160/TH05-11-0777.Mannila M.N., Eriksson P., Ericsson C.G., Hamsten A., Silveira A. Epistatic and pleiotropic effects of polymorphisms in the fibrinogen and coagulation factor XIII genes on plasma fibrinogen concentration, fibrin gel structure and risk of myocardial infarction. Thromb Haemost, 2006, vol. 95, no. 3, pp.420-427. doi: 10.1160/TH05-11-0777.Wells P.S., Anderson J.L., Scarvelis D.K, Doucette S.P., Gagnon F. Factor XIII Val34Leu variant is protective against venous thromboembolism: a HuGE review and metaanalysis. Am. J. Epidemiol, 2006, vol. 164, no. 2, pp. 101-109. doi: 10.1093/aje/kwj179.Wells P.S., Anderson J.L., Scarvelis D.K, Doucette S.P., Gagnon F. Factor XIII Val34Leu variant is protective against venous thromboembolism: a HuGE review and metaanalysis. Am. J. Epidemiol, 2006, vol. 164, no. 2, pp. 101-109. doi: 10.1093/aje/kwj179.Dull K., Fazekas F., Törocsik D. Factor XIII-A in Diseases: Role Beyond Blood Coagulation. Int. J. Mol. Sci, 2021, vol. 22, no. 3, pp. 1459. doi: 10.3390/ijms22031459.Dull K., Fazekas F., Törocsik D. Factor XIII-A in Diseases: Role Beyond Blood Coagulation. Int. J. Mol. Sci, 2021, vol. 22, no. 3, pp. 1459. doi: 10.3390/ijms22031459.Ambroziak M., Kuryłowicz A., Budaj A. Increased coagulation factor XIII activity but not genetic variants of coagulation factors is associated with myocardial infarction in young patients. J. Thromb. Thrombolysis, 2019, vol. 48, no. 3, pp. 519-527. doi: 10.1007/s11239-019-01856-3.Ambroziak M., Kuryłowicz A., Budaj A. Increased coagulation factor XIII activity but not genetic variants of coagulation factors is associated with myocardial infarction in young patients. J. Thromb. Thrombolysis, 2019, vol. 48, no. 3, pp. 519-527. doi: 10.1007/s11239-019-01856-3.Mannila M.N., Eriksson P., Leander K., Wiman B., de Faire U., Hamsten A., Silveira A. The association between fibrinogen haplotypes and myocardial infarction in men is partly mediated through pleiotropic effects on the serum IL-6 concentration. J. Intern. Med., 2007, vol. 261, no. 2, pp. 138-147. doi: 10.1111/j.1365-2796.2006.01749.x.Mannila M.N., Eriksson P., Leander K., Wiman B., de Faire U., Hamsten A., Silveira A. The association between fibrinogen haplotypes and myocardial infarction in men is partly mediated through pleiotropic effects on the serum IL-6 concentration. J. Intern. Med., 2007, vol. 261, no. 2, pp. 138-147. doi: 10.1111/j.1365-2796.2006.01749.x.Van Cott E.M., Laposata M. Laboratory evaluation of hypercoagulable states. Hematol. Oncol. Clin. North. Am, 1998, vol. 12, no. 6, pp.1141-1166. doi: 10.1016/j.cll.2009.03.002.Van Cott E.M., Laposata M. Laboratory evaluation of hypercoagulable states. Hematol. Oncol. Clin. North. Am, 1998, vol. 12, no. 6, pp.1141-1166. doi: 10.1016/j.cll.2009.03.002.Juul K., Tybjaerg-Hansen A., Schnohr P., Nordestgaard B.G. Factor V Leiden and the risk for venous thromboembolism in the adult Danish population. Ann. Intern. Med, 2004, vol. 140, no. 5, pp. 330-337. doi: 10.7326/0003-4819-140-5-200403020-00008.Juul K., Tybjaerg-Hansen A., Schnohr P., Nordestgaard B.G. Factor V Leiden and the risk for venous thromboembolism in the adult Danish population. Ann. Intern. Med, 2004, vol. 140, no. 5, pp. 330-337. doi: 10.7326/0003-4819-140-5-200403020-00008.Casas J.P., Hingorani A.D., Bautista L.E., Sharma P. Meta-analysis of genetic studies in ischemic stroke: thirty-two genes involving approximately 18,000 cases and 58,000 controls. Arch. Neurol, 2004, vol. 61, no. 11, pp. 1652-1661. doi: 10.1001/archneur.61.11.1652.Casas J.P., Hingorani A.D., Bautista L.E., Sharma P. Meta-analysis of genetic studies in ischemic stroke: thirty-two genes involving approximately 18,000 cases and 58,000 controls. Arch. Neurol, 2004, vol. 61, no. 11, pp. 1652-1661. doi: 10.1001/archneur.61.11.1652.Bentley P., Peck G., Smeeth L., Whittaker J., Sharma P. Causal relationship of susceptibility genes to ischemic stroke: comparison to ischemic heart disease and biochemical determinants. PLoS One, 2010, vol. 5, no. 2, pp. e9136. doi: 10.1371/journal.pone.0009136.Bentley P., Peck G., Smeeth L., Whittaker J., Sharma P. Causal relationship of susceptibility genes to ischemic stroke: comparison to ischemic heart disease and biochemical determinants. PLoS One, 2010, vol. 5, no. 2, pp. e9136. doi: 10.1371/journal.pone.0009136.Zee R.Y.L., Bubes V., Shrivastava S., Ridker P.M., Glynn R.J. Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach. Clin. Chim. Acta, 2009, vol. 402, no. 1-2, pp. 189-192. doi: 10.1016/j.cca.2009.01.011.Zee R.Y.L., Bubes V., Shrivastava S., Ridker P.M., Glynn R.J. Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach. Clin. Chim. Acta, 2009, vol. 402, no. 1-2, pp. 189-192. doi: 10.1016/j.cca.2009.01.011.Lynch A.I., Eckfeldt J.H., Davis B.R., Ford C.E., Boerwinkle E., Leiendecker-Foster C., Arnett D.K. Gene panels to help identify subgroups at high and low risk of coronary heart disease among those randomized to antihypertensive treatment: the GenHAT study. Pharmacogenet Genomics, 2012, vol. 22, no. 5, pp. 355-366. doi: 10.1097/fpc.0b013e3283516ff8.Lynch A.I., Eckfeldt J.H., Davis B.R., Ford C.E., Boerwinkle E., Leiendecker-Foster C., Arnett D.K. Gene panels to help identify subgroups at high and low risk of coronary heart disease among those randomized to antihypertensive treatment: the GenHAT study. Pharmacogenet Genomics, 2012, vol. 22, no. 5, pp. 355-366. doi: 10.1097/fpc.0b013e3283516ff8.Li Y., Bezemer I.D., Rowland C.M., Tong C.H., Arellano A.R., Catanese J.J., Devlin J.J., Reitsma P.H., Bare L.A., Rosendaal F.R. Genetic variants associated with deep vein thrombosis: the F11 locus. J. Thromb. Haemost, 2009, vol. 7, no. 11, pp. 1802-1808. doi: 10.1111/j.1538-7836.2009.03544.x.Li Y., Bezemer I.D., Rowland C.M., Tong C.H., Arellano A.R., Catanese J.J., Devlin J.J., Reitsma P.H., Bare L.A., Rosendaal F.R. Genetic variants associated with deep vein thrombosis: the F11 locus. J. Thromb. Haemost, 2009, vol. 7, no. 11, pp. 1802-1808. doi: 10.1111/j.1538-7836.2009.03544.x.Reiner A.P., Lange L.A., Smith N.L., Zakai N.A., Cushman M., Folsom A.R. Common hemostasis and inflammation gene variants and venous thrombosis in older adults from the Cardiovascular Health Study. J. Thromb. Haemost. 2009, vol. 7, no. 9, pp. 1499-1505. doi: 10.1111/j.1538-7836.2009.03522.x.Reiner A.P., Lange L.A., Smith N.L., Zakai N.A., Cushman M., Folsom A.R. Common hemostasis and inflammation gene variants and venous thrombosis in older adults from the Cardiovascular Health Study. J. Thromb. Haemost. 2009, vol. 7, no. 9, pp. 1499-1505. doi: 10.1111/j.1538-7836.2009.03522.x.ElGalaly T.C., Severinsen M.T., Overvad K., Steffensen R., Vistisen A.K., Tjønneland A., Kristensen S.R. Single nucleotide polymorphisms and the risk of venous thrombosis: results from a Danish case-cohort study. Br. J. Haematol. 2013, vol. 160, no. 6, pp. 838-841. doi: 10.1111/bjh.12132.ElGalaly T.C., Severinsen M.T., Overvad K., Steffensen R., Vistisen A.K., Tjønneland A., Kristensen S.R. Single nucleotide polymorphisms and the risk of venous thrombosis: results from a Danish case-cohort study. Br. J. Haematol. 2013, vol. 160, no. 6, pp. 838-841. doi: 10.1111/bjh.12132.Delluc A., Gourhant L., Lacut K., Mercier B., Audrezet M.P., Nowak E., Oger E., Leroyer C., Mottier D., Le Gal G., Couturaud F. Association of common genetic variations and idiopathic venous thromboembolism. Results from EDITh, a hospital-based case-control study. Thromb. Haemost. 2010, vol. 103, no. 6, pp. 1161-1169. doi: 10.1160/TH09-07-0430.Delluc A., Gourhant L., Lacut K., Mercier B., Audrezet M.P., Nowak E., Oger E., Leroyer C., Mottier D., Le Gal G., Couturaud F. Association of common genetic variations and idiopathic venous thromboembolism. Results from EDITh, a hospital-based case-control study. Thromb. Haemost. 2010, vol. 103, no. 6, pp. 1161-1169. doi: 10.1160/TH09-07-0430.Rovite V., Maurins U., Megnis K., Vaivade I., Pečulis R., Rits J., Prave S., Klovins J. Association of F11 polymorphism rs2289252 with deep vein thrombosis and related phenotypes in population of Latvia. Thromb. Res, 2014, vol. 134, no. 3, pp. 659-663. doi: 10.1016/j.thromres.2014.07.011.Rovite V., Maurins U., Megnis K., Vaivade I., Pečulis R., Rits J., Prave S., Klovins J. Association of F11 polymorphism rs2289252 with deep vein thrombosis and related phenotypes in population of Latvia. Thromb. Res, 2014, vol. 134, no. 3, pp. 659-663. doi: 10.1016/j.thromres.2014.07.011.Theodoraki E.V., Nikopensius T., Suhorutsenko J., Peppes V., Fili P., Kolovou G., Papamikos V., Richter D., Zakopoulos N., Krjutskov K., Metspalu A., Dedoussis G.V. Fibrinogen beta variants confer protection against coronary artery disease in a Greek case-control study. BMC Med. Genet, 2010, vol. 11. doi: 10.1186/1471-2350-11-28.Theodoraki E.V., Nikopensius T., Suhorutsenko J., Peppes V., Fili P., Kolovou G., Papamikos V., Richter D., Zakopoulos N., Krjutskov K., Metspalu A., Dedoussis G.V. Fibrinogen beta variants confer protection against coronary artery disease in a Greek case-control study. BMC Med. Genet, 2010, vol. 11. doi: 10.1186/1471-2350-11-28.de Willige S.U., de Visser M.C., Houwing-Duistermaat J.J., Rosendaal F.R., Vos H.L., Bertina R.M. Genetic variation in the fibrinogen gamma gene increases the risk for deep venous thrombosis by reducing plasma fibrinogen gamma’ levels. Blood. 2005, vol. 106, no. 13, pp. 4176-4183. doi: 10.1182/blood-2005-05-2180.de Willige S.U., de Visser M.C., Houwing-Duistermaat J.J., Rosendaal F.R., Vos H.L., Bertina R.M. Genetic variation in the fibrinogen gamma gene increases the risk for deep venous thrombosis by reducing plasma fibrinogen gamma’ levels. Blood. 2005, vol. 106, no. 13, pp. 4176-4183. doi: 10.1182/blood-2005-05-2180.Grünbacher G., Weger W., Marx-Neuhold E., Pilger E., Köppel H., Wascher T., März W., Renner W. The fibrinogen gamma (FGG) 10034C>T polymorphism is associated with venous thrombosis. Thromb. Res, 2007, vol. 121, no. 1, pp. 33-36. doi: 10.1016/j.thromres.2007.03.007.Grünbacher G., Weger W., Marx-Neuhold E., Pilger E., Köppel H., Wascher T., März W., Renner W. The fibrinogen gamma (FGG) 10034C>T polymorphism is associated with venous thrombosis. Thromb. Res, 2007, vol. 121, no. 1, pp. 33-36. doi: 10.1016/j.thromres.2007.03.007.Horvei L.D., Braekkan S.K., Smith E.N., Solomon T., Hindberg K., Frazer K.A., Rosendaal F.R., Hansen J.B. Joint effects of prothrombotic genotypes and body height on the risk of venous thromboembolism: the Tromsø study. J. Thromb. Haemost. 2018, vol. 16, no. 1, pp.83-89. doi: 10.1111/jth.13892.3.Horvei L.D., Braekkan S.K., Smith E.N., Solomon T., Hindberg K., Frazer K.A., Rosendaal F.R., Hansen J.B. Joint effects of prothrombotic genotypes and body height on the risk of venous thromboembolism: the Tromsø study. J. Thromb. Haemost. 2018, vol. 16, no. 1, pp.83-89. doi: 10.1111/jth.13892.3.Rinde L.B., Morelli V.M., Småbrekke B., Mathiesen E.B., Løchen M.L., Njølstad I., Wilsgaard T., Smith E., Rosendaal F.R., Frazer K.A., Braekkan S.K., Hansen J.B. Effect of prothrombotic genotypes on the risk of venous thromboembolism in patients with and without ischemic stroke. The Tromsø Study. J. Thromb. Haemost, 2019, vol. 17, no. 5, pp. 749-758. doi: 10.1111/jth.14410.Rinde L.B., Morelli V.M., Småbrekke B., Mathiesen E.B., Løchen M.L., Njølstad I., Wilsgaard T., Smith E., Rosendaal F.R., Frazer K.A., Braekkan S.K., Hansen J.B. Effect of prothrombotic genotypes on the risk of venous thromboembolism in patients with and without ischemic stroke. The Tromsø Study. J. Thromb. Haemost, 2019, vol. 17, no. 5, pp. 749-758. doi: 10.1111/jth.14410.Sejrup J.K., Morelli V.M., Løchen M.L., Njølstad I., Mathiesen E.B., Wilsgaard T., Hansen J.B., Brækkan S.K. Myocardial infarction, prothrombotic genotypes, and venous thrombosis risk: The Tromsø Study. Res. Pract. Thromb. Haemost, 2020, vol. 4, no. 2, pp. 247-254. doi: 10.1002/rth2.12306.Sejrup J.K., Morelli V.M., Løchen M.L., Njølstad I., Mathiesen E.B., Wilsgaard T., Hansen J.B., Brækkan S.K. Myocardial infarction, prothrombotic genotypes, and venous thrombosis risk: The Tromsø Study. Res. Pract. Thromb. Haemost, 2020, vol. 4, no. 2, pp. 247-254. doi: 10.1002/rth2.12306.Tomasoni M., Beyeler M.J., Vela S.O., Mounier N., Porcu E., Corre T., Krefl D., Button A.L, Abouzeid H., Lazaros K., Bochud M., Schlingemann R., Bergin C., Bergmann S. Genome-wide Association Studies of Retinal Vessel Tortuosity Identify Numerous Novel Loci Revealing Genes and Pathways Associated With Ocular and Cardiometabolic Diseases. Ophthalmol. Sci, 2023, vol. 3, no. 3, pp. 100288. doi: 10.1016/j.xops.2023.100288.Tomasoni M., Beyeler M.J., Vela S.O., Mounier N., Porcu E., Corre T., Krefl D., Button A.L, Abouzeid H., Lazaros K., Bochud M., Schlingemann R., Bergin C., Bergmann S. Genome-wide Association Studies of Retinal Vessel Tortuosity Identify Numerous Novel Loci Revealing Genes and Pathways Associated With Ocular and Cardiometabolic Diseases. Ophthalmol. Sci, 2023, vol. 3, no. 3, pp. 100288. doi: 10.1016/j.xops.2023.100288.

The authors declare that there are no conflicts of interest present.