<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">emcardio</journal-id><journal-title-group><journal-title xml:lang="ru">Неотложная кардиология и кардиоваскулярные риски</journal-title><trans-title-group xml:lang="en"><trans-title>Emergency Cardiology and Cardiovascular Risks journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2616-633X</issn><publisher><publisher-name>Белорусский государственный медицинский университет</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">emcardio-277</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Оригинальные научные публикации</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Original Scientific Research</subject></subj-group></article-categories><title-group><article-title>Оценка риска кардиохирургических вмешательств у пациентов со сниженной сократительной способностью миокарда. Часть 2. Маркеры миокардиального стресса и повреждения миокарда</article-title><trans-title-group xml:lang="en"><trans-title>Risk stratification of cardiovascular interventions in patients with reduced myocardial contractility. Part2. Markers of myocardial stress and injury</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шумовец</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Shumavets</surname><given-names>V. V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Панкратов</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Pankratov</surname><given-names>A. V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Колядко</surname><given-names>М. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Kaljadka</surname><given-names>M. G.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шибеко</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Shibeko</surname><given-names>N.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гринчук</surname><given-names>И. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Grinchuk</surname><given-names>I. I.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Русских</surname><given-names>И. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Russkih</surname><given-names>I. I.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лысенок</surname><given-names>Е. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Lysenok</surname><given-names>E. R.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Островский</surname><given-names>Ю. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Ostrovski</surname><given-names>Y. P.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Республиканский научно-практический центр «Кардиология»</institution></aff><aff xml:lang="en"><institution>Republic Scientific and Practical Centre «Cardiology»</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Белорусский государственный медицинский университет</institution></aff><aff xml:lang="en"><institution>Belarus State Medical University</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>13</day><month>11</month><year>2025</year></pub-date><volume>2</volume><issue>2</issue><fpage>405</fpage><lpage>412</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Шумовец В.В., Панкратов А.В., Колядко М.Г., Шибеко Н.А., Гринчук И.И., Русских И.И., Лысенок Е.Р., Островский Ю.П., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Шумовец В.В., Панкратов А.В., Колядко М.Г., Шибеко Н.А., Гринчук И.И., Русских И.И., Лысенок Е.Р., Островский Ю.П.</copyright-holder><copyright-holder xml:lang="en">Shumavets V.V., Pankratov A.V., Kaljadka M.G., Shibeko N., Grinchuk I.I., Russkih I.I., Lysenok E.R., Ostrovski Y.P.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://emcardio.bsmu.by/jour/article/view/277">https://emcardio.bsmu.by/jour/article/view/277</self-uri><abstract><p>Стратификация риска пациентов кардиохирургического профиля с хронической сердечной недостаточностью может быть уточнена с применением биомаркеров различных патофизиологических процессов. Цель: определение периоперационной динамики, закономерности и выявление прогностической ценностиновых кардиальных биомаркеров (миокардиального ремоделирования, миокардиального стресса, миокардиального повреждения и воспаления) у пациентов со сниженной сократительной способностью миокарда.</p></abstract><trans-abstract xml:lang="en"><p>Background: Background: Background: Background: Background: Only clinical risk factors alone are used in current preoperative models estimating risk of hospital mortality following cardiac surgery. However, novel biomarkers such as Nterminal pro Btype natriuretic peptide (NTProBNP), high - sensitivity troponin I (hsTnI) or Galectin$3 potentially can improve the predictive ability and capacity to risk stratify patients before cardiac surgery. In this part we aimed to assess these novel biomarkers of cardiac remodeling and injury periope-ratively open heart surgery in patients with low ejection fraction.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>аорто-коронарное шунтирование</kwd><kwd>пластика митрального клапана</kwd><kwd>хроническая сердечная недостаточность</kwd><kwd>миокардиальные биомаркеры</kwd><kwd>стратификация риска хирургического вмешательства</kwd></kwd-group><kwd-group xml:lang="en"><kwd>avascular necrosis of the bone</kwd><kwd>metabolic syndrome</kwd><kwd>endothelial dysfunction</kwd><kwd>atherosclerosis</kwd><kwd>bone turnover</kwd><kwd>osteoprotegerin</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Mebazaa A., Pitsis A.A., Rudiger A., Toller W., Longrois D., Ricksten S.E., Bobek I., De Hert S., Wieselthaler G., Schirmer U., von Segesser L.K., Sander M., Poldermans D., Ranucci M., Karpati P.C., Wouters P., Seeberger M., Schmid E.R., Weder W., Follath F. Clinical review: Practical recommendations on the management of perioperative heart failure in cardiac surgery. Critical Care, 2010, vol. 14, № 2, pp. 201–215.</mixed-citation><mixed-citation xml:lang="en">Mebazaa A., Pitsis A.A., Rudiger A., Toller W., Longrois D., Ricksten S.E., Bobek I., De Hert S., Wieselthaler G., Schirmer U., von Segesser L.K., Sander M., Poldermans D., Ranucci M., Karpati P.C., Wouters P., Seeberger M., Schmid E.R., Weder W., Follath F. Clinical review: Practical recommendations on the management of perioperative heart failure in cardiac surgery. Critical Care, 2010, vol. 14, № 2, pp. 201–215.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Nashef S.A., Roques F., Sharples L.D., Nilsson J., Smith C., Goldstone A.R., Lockowandt U. EuroSCORE II. Eur J Cardiothorac Surg, 2012, vol. 41, № 4, pp. 734–744.</mixed-citation><mixed-citation xml:lang="en">Nashef S.A., Roques F., Sharples L.D., Nilsson J., Smith C., Goldstone A.R., Lockowandt U. EuroSCORE II. Eur J Cardiothorac Surg, 2012, vol. 41, № 4, pp. 734–744.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Lenz M., Krychtiuk K.A., Goliasch G., Distelmaier K., Wojta J., Heinz G., Speidl W.S. N-terminal pro-brain natriuretic peptide and high sensitivity troponin T exhibit additive prognostic value for the outcome of critically ill. Eur Heart J Acute Cardiovasc Care, 2018, Apr 1:2048872618768088. doi: 10.1177/2048872618768088.</mixed-citation><mixed-citation xml:lang="en">Lenz M., Krychtiuk K.A., Goliasch G., Distelmaier K., Wojta J., Heinz G., Speidl W.S. N-terminal pro-brain natriuretic peptide and high sensitivity troponin T exhibit additive prognostic value for the outcome of critically ill. Eur Heart J Acute Cardiovasc Care, 2018, Apr 1:2048872618768088. doi: 10.1177/2048872618768088.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Braunwald E. Heart failure. JACC: Heart Fail, 2013, vol. 1, № 1, pp. 1–20. doi:10.1016/j.jchf.2012.10.002.</mixed-citation><mixed-citation xml:lang="en">Braunwald E. Heart failure. JACC: Heart Fail, 2013, vol. 1, № 1, pp. 1–20. doi:10.1016/j.jchf.2012.10.002.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Taub P.R., Daniels L.B., Maisel L.S Usefulness of B-type natriuretic peptide levels in predicting hemodynamic and clinical decompensation. Heart Fail Clin. 2009, vol. 5, № 2, pp. 169–175. doi: 10.1016/j.hfc.2008.11.009.</mixed-citation><mixed-citation xml:lang="en">Taub P.R., Daniels L.B., Maisel L.S Usefulness of B-type natriuretic peptide levels in predicting hemodynamic and clinical decompensation. Heart Fail Clin. 2009, vol. 5, № 2, pp. 169–175. doi: 10.1016/j.hfc.2008.11.009.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Januzzi J.L.Jr., Rehman S.U., Mohammed A.A., Bhardwaj A., Barajas L., Barajas J., Kim H.N., Baggish A.L., Weiner R.B., Chen-Tournoux A., Marshall J.E., Moore S.A., Carlson W.D., Lewis G.D., Shin J., Sullivan D., Parks K., Wang T.J., Gregory S.A., Uthamalingam S., Semigran M.J. Use of amino-terminal pro-B-type natriuretic peptide to guide outpatient therapy of patients with chronic left ventricular systolic dysfunction. J Am Coll Cardiol, 2011, vol. 58, № 18, pp. 1881–1889.</mixed-citation><mixed-citation xml:lang="en">Januzzi J.L.Jr., Rehman S.U., Mohammed A.A., Bhardwaj A., Barajas L., Barajas J., Kim H.N., Baggish A.L., Weiner R.B., Chen-Tournoux A., Marshall J.E., Moore S.A., Carlson W.D., Lewis G.D., Shin J., Sullivan D., Parks K., Wang T.J., Gregory S.A., Uthamalingam S., Semigran M.J. Use of amino-terminal pro-B-type natriuretic peptide to guide outpatient therapy of patients with chronic left ventricular systolic dysfunction. J Am Coll Cardiol, 2011, vol. 58, № 18, pp. 1881–1889.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Ponikowski P., Voors A.A., Anker S.D., Bueno H., Cleland J.G.F., Coats A.J.S., Falk V., Gonz lez-Juanatey J.R., Harjola V.P., Jankowska E.A., Jessup M., Linde C., Nihoyannopoulos P., Parissis J.T., Pieske B., Riley J.P., Rosano G.M.C., Ruilope L.M., Ruschitzka F., Rutten F.H., van der Meer P. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart. Eur Heart J, 2016, vol. 37, № 27, pp. 2129–2200.</mixed-citation><mixed-citation xml:lang="en">Ponikowski P., Voors A.A., Anker S.D., Bueno H., Cleland J.G.F., Coats A.J.S., Falk V., Gonz lez-Juanatey J.R., Harjola V.P., Jankowska E.A., Jessup M., Linde C., Nihoyannopoulos P., Parissis J.T., Pieske B., Riley J.P., Rosano G.M.C., Ruilope L.M., Ruschitzka F., Rutten F.H., van der Meer P. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart. Eur Heart J, 2016, vol. 37, № 27, pp. 2129–2200.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Maisel A., Mueller C., Adams K.Jr., Anker S.D., Aspromonte N., Cleland J.G., Cohen-Solal A., Dahlstrom U., DeMaria A., Di Somma S., Filippatos G.S., Fonarow G.C., Jourdain P., Komajda M., Liu P.P., McDonagh T., McDonald K., Mebazaa A., Nieminen M.S., Peacock W.F., Tubaro M., Valle R., Vander-hyden M., Yancy C.W., Zannad F., Braunwald E. State of the art: Using natriuretic peptide levels in clinical practice. Eur J Heart Fail, 2008, vol. 10, № 9, pp. 824–839.</mixed-citation><mixed-citation xml:lang="en">Maisel A., Mueller C., Adams K.Jr., Anker S.D., Aspromonte N., Cleland J.G., Cohen-Solal A., Dahlstrom U., DeMaria A., Di Somma S., Filippatos G.S., Fonarow G.C., Jourdain P., Komajda M., Liu P.P., McDonagh T., McDonald K., Mebazaa A., Nieminen M.S., Peacock W.F., Tubaro M., Valle R., Vander-hyden M., Yancy C.W., Zannad F., Braunwald E. State of the art: Using natriuretic peptide levels in clinical practice. Eur J Heart Fail, 2008, vol. 10, № 9, pp. 824–839.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Karthikeyan G., Moncur R.A., Levine O., Heels-Ansdell D., Chan M.T., Alonso-Coello P., Yusuf S., Sessler D., Villar J.C., Berwanger O., McQueen M.,Mathew A., Hill S., Gibson S., Berry C., Yeh H.M., Devereaux P.J. Is a pre-operative brain natriuretic peptide or N-terminal pro-B-type natriuretic peptide measurement an independent predictor of adverse cardiovascular outcomes within 30 days of noncardiac surgery? A systematic review and meta-analysis of observational studies. J Am Coll Cardiol, 2009, vol. 54, № 17, pp. 1599–1606.</mixed-citation><mixed-citation xml:lang="en">Karthikeyan G., Moncur R.A., Levine O., Heels-Ansdell D., Chan M.T., Alonso-Coello P., Yusuf S., Sessler D., Villar J.C., Berwanger O., McQueen M.,Mathew A., Hill S., Gibson S., Berry C., Yeh H.M., Devereaux P.J. Is a pre-operative brain natriuretic peptide or N-terminal pro-B-type natriuretic peptide measurement an independent predictor of adverse cardiovascular outcomes within 30 days of noncardiac surgery? A systematic review and meta-analysis of observational studies. J Am Coll Cardiol, 2009, vol. 54, № 17, pp. 1599–1606.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Rodseth R.N., Biccard B.M., Le Manach Y., Sessler D.I., Lurati Buse G.A., Thabane L., Schutt R.C., Bolliger D., Cagini L., Cardinale D., Chong C.P., Chu R., Cnotliwy M., Di Somma S., Fahrner R., Lim W.K., Mahla E., Manikandan R., Puma F., Pyun W.B., Radovi M., Rajagopalan S., Suttie S., Vanniyasingam T., van Gaal W.J., Waliszek M., Devereaux P.J. The prognostic value of pre-operative and post-operative B-type natriuretic peptides in patients undergoing noncardiac surgery: B-type natriuretic peptide and N-terminal fragment of pro-B-type natriuretic peptide: a systematic review and individual patient data meta-analysis. J Am Coll Cardiol, 2014, vol. 63, № 2, pp.170–180.</mixed-citation><mixed-citation xml:lang="en">Rodseth R.N., Biccard B.M., Le Manach Y., Sessler D.I., Lurati Buse G.A., Thabane L., Schutt R.C., Bolliger D., Cagini L., Cardinale D., Chong C.P., Chu R., Cnotliwy M., Di Somma S., Fahrner R., Lim W.K., Mahla E., Manikandan R., Puma F., Pyun W.B., Radovi M., Rajagopalan S., Suttie S., Vanniyasingam T., van Gaal W.J., Waliszek M., Devereaux P.J. The prognostic value of pre-operative and post-operative B-type natriuretic peptides in patients undergoing noncardiac surgery: B-type natriuretic peptide and N-terminal fragment of pro-B-type natriuretic peptide: a systematic review and individual patient data meta-analysis. J Am Coll Cardiol, 2014, vol. 63, № 2, pp.170–180.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Polineni S., Parker D.M., Alam S.S., Thiessen-Philbrook H., McArthur E., DiScipio A.W., Malenka D.J., Parikh C.R, Garg A.X., Brown J.R. Predictive Ability of Novel Cardiac Biomarkers ST2, Galectin-3, and NT-ProBNP Before Cardiac Surgery. J Am Heart Assoc, 2018, vol. 7, № 4, pii: e008371. doi: 10.1161/JAHA.117.008371.</mixed-citation><mixed-citation xml:lang="en">Polineni S., Parker D.M., Alam S.S., Thiessen-Philbrook H., McArthur E., DiScipio A.W., Malenka D.J., Parikh C.R, Garg A.X., Brown J.R. Predictive Ability of Novel Cardiac Biomarkers ST2, Galectin-3, and NT-ProBNP Before Cardiac Surgery. J Am Heart Assoc, 2018, vol. 7, № 4, pii: e008371. doi: 10.1161/JAHA.117.008371.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Thygesen K., Alpert J.S., Jaffe A.S., Chaitman B.R., Bax J.J., Morrow D.A., White H.D. Fourth universal definition of myocardial infarction. Eur Heart J, 2018, Aug 25. doi: 10.1093/eurheartj/ehy462.</mixed-citation><mixed-citation xml:lang="en">Thygesen K., Alpert J.S., Jaffe A.S., Chaitman B.R., Bax J.J., Morrow D.A., White H.D. Fourth universal definition of myocardial infarction. Eur Heart J, 2018, Aug 25. doi: 10.1093/eurheartj/ehy462.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Baron J.M., Lewandrowski E.L., Januzzi J.L., Bajwa E.K., Thompson B.T., Lewandrowski K.B. Measurement of high-sensitivity troponin T in noncardiac medical intensive care unit patients. Correlation to mortality and length of stay. Am J Clin Pathol, 2014, vol. 141, № 4, pp. 488–493.</mixed-citation><mixed-citation xml:lang="en">Baron J.M., Lewandrowski E.L., Januzzi J.L., Bajwa E.K., Thompson B.T., Lewandrowski K.B. Measurement of high-sensitivity troponin T in noncardiac medical intensive care unit patients. Correlation to mortality and length of stay. Am J Clin Pathol, 2014, vol. 141, № 4, pp. 488–493.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">] Brown J.R., Jacobs J.P., Alam S.S., Thiessen Philbrook H., Everett A., Likosky D.S., Lobdell K., Wyler von Ballmoos M.C., Parker D.M., Garg A.X., Mackenzie T., Jacobs M.L., Parikh C.R. Utility of Biomarkers to Improve Prediction of Readmission or Mortality After Cardiac Surgery. Ann Thorac Surg, 2018, Aug 4, pii: S0003 4975(18)31058 0. doi: 10.1016/ j.athoracsur.2018.06.052.</mixed-citation><mixed-citation xml:lang="en">] Brown J.R., Jacobs J.P., Alam S.S., Thiessen Philbrook H., Everett A., Likosky D.S., Lobdell K., Wyler von Ballmoos M.C., Parker D.M., Garg A.X., Mackenzie T., Jacobs M.L., Parikh C.R. Utility of Biomarkers to Improve Prediction of Readmission or Mortality After Cardiac Surgery. Ann Thorac Surg, 2018, Aug 4, pii: S0003 4975(18)31058 0. doi: 10.1016/ j.athoracsur.2018.06.052.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Shen J.T., Xu M., Wu Y., Wen S.H., Li X., Zhao B.C., Huang W.Q. Association of pre-operative troponin levels with major adverse cardiac events and mortality after noncardiac surgery: A systematic review and meta-analysis. Eur J Anaesthesiol, 2018, vol. 35, № 11, pp. 815–824.</mixed-citation><mixed-citation xml:lang="en">Shen J.T., Xu M., Wu Y., Wen S.H., Li X., Zhao B.C., Huang W.Q. Association of pre-operative troponin levels with major adverse cardiac events and mortality after noncardiac surgery: A systematic review and meta-analysis. Eur J Anaesthesiol, 2018, vol. 35, № 11, pp. 815–824.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Norusis M. SPSS 13.0 Guide to Data Analysis. Upper Saddle River, N.J.: Prentice Hall, Inc, 2004, pp. 134.</mixed-citation><mixed-citation xml:lang="en">Norusis M. SPSS 13.0 Guide to Data Analysis. Upper Saddle River, N.J.: Prentice Hall, Inc, 2004, pp. 134.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Glantz S.A. Primer of Biostatistics. New York [etc]: McGrawHill Medical, 1994. (Russ. ed.: Danilov Yu.A., Buzikashvili N.E., Samoylov D.V. Medikobiologicheskaya statistika. Moscow: Praktika , 1999. 119 p.).</mixed-citation><mixed-citation xml:lang="en">Glantz S.A. Primer of Biostatistics. New York [etc]: McGrawHill Medical, 1994. (Russ. ed.: Danilov Yu.A., Buzikashvili N.E., Samoylov D.V. Medikobiologicheskaya statistika. Moscow: Praktika , 1999. 119 p.).</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
