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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">emcardio</journal-id><journal-title-group><journal-title xml:lang="ru">Неотложная кардиология и кардиоваскулярные риски</journal-title><trans-title-group xml:lang="en"><trans-title>Emergency Cardiology and Cardiovascular Risks journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2616-633X</issn><publisher><publisher-name>Белорусский государственный медицинский университет</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">emcardio-269</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Оригинальные научные публикации</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Original Scientific Research</subject></subj-group></article-categories><title-group><article-title>Физиологическая оценка результатов спектрометрии содержания оксигемоглобина и реакции микрососудов на изменение гемодинамики</article-title><trans-title-group xml:lang="en"><trans-title>Physiological evaluation of spectrometry results of oxyhemoglobin content and response of microvessels to hemodynamic changes</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кубарко</surname><given-names>А. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Kubarko</surname><given-names>A. I.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фираго</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Firago</surname><given-names>V. A.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>Белорусский государственный медицинский университет</institution><country>Belarus</country></aff><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Белорусский государственный университет</institution></aff><aff xml:lang="en"><institution>Belarusian State University</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>13</day><month>11</month><year>2025</year></pub-date><volume>2</volume><issue>2</issue><fpage>358</fpage><lpage>363</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кубарко А.И., Фираго В.А., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Кубарко А.И., Фираго В.А.</copyright-holder><copyright-holder xml:lang="en">Kubarko A.I., Firago V.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://emcardio.bsmu.by/jour/article/view/269">https://emcardio.bsmu.by/jour/article/view/269</self-uri><abstract><p>Проанализированы данные спектрометрических измерений плотности, площади сечения микроциркуляторных сосудов поверхностных тканей, содержания в крови тканевых сосудов оксигемоглобина и их реакции на прекращение кровотока, ограничение притока артериальной крови и блокады оттока венозной крови. Характер и направленность полученных изменений согласуются с существующими представлениями о физиологических и патофизиологических механизмах реагирования сосудов и метаболизма тканей на нарушения локального кровотока. Метод спектрометрии может найти применение для оценки соответствия микроциркуляции метаболическим потребностям тканей в условиях физиологических нагрузок и патологии.</p></abstract><trans-abstract xml:lang="en"><p>Spectroscopic measurements of the density and cross-sectional area of microcirculation vessels of superficial tissues, oxyhemoglobin blood content in these vessels and their response to the blood flow cessation, restriction of arterial blood flow and blockade of venous outflow have been analyzed. The character and direction of the revealed changes are consistent with the existing concepts of the physiological and pathophysiological mechanisms of vascular and tissue metabolism response to the local blood flow disorders. The spectrometry method can be used to assess the compliance of microcirculation to the tissues metabolic needs in functional stress and pathology.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>спектрометрия</kwd><kwd>микроциркуляция</kwd><kwd>оксигемоглобин</kwd><kwd>потребление кислорода</kwd><kwd>метаболизм тканей</kwd></kwd-group><kwd-group xml:lang="en"><kwd>spectrometry</kwd><kwd>microcirculation</kwd><kwd>oxyhemoglobin</kwd><kwd>oxygen consumption</kwd><kwd>tissue metabolism</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Shury’gin I.A. Monitoring dy’haniya: p u l’soksimetriya, kapnografiya, oksimetriya [Breath monitoring: pulse oximetry, capnography, oximetry]. SPb: Nevskiy Dialekt ; M. : BINOM, 2000, 301 p. (in Russian).</mixed-citation><mixed-citation xml:lang="en">Shury’gin I.A. Monitoring dy’haniya: p u l’soksimetriya, kapnografiya, oksimetriya [Breath monitoring: pulse oximetry, capnography, oximetry]. SPb: Nevskiy Dialekt ; M. : BINOM, 2000, 301 p. (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Hitachi Developing Non-Invasive Blood Sugar Monitoring Device. Proprietary Technologies Would Take the Pain and Hassle Out of Measuring Blood Sugar Levels [electronic resource]. Available at: https:// www.yumpu.com/en/document/view/22311684/hitachi-developing-non- invasive-blood-sugar-monitoring-device. (accessed: 19. 10. 2017).</mixed-citation><mixed-citation xml:lang="en">Hitachi Developing Non-Invasive Blood Sugar Monitoring Device. Proprietary Technologies Would Take the Pain and Hassle Out of Measuring Blood Sugar Levels [electronic resource]. Available at: https:// www.yumpu.com/en/document/view/22311684/hitachi-developing-non- invasive-blood-sugar-monitoring-device. (accessed: 19. 10. 2017).</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Tuchina V.V. eds. Opticheskaya biomedicinskaya diagnostika. T 1. [Optical biomedical diagnostics. T.1]. Moskw: FizMatLit, 2007, 560 s. (in Russian).</mixed-citation><mixed-citation xml:lang="en">Tuchina V.V. eds. Opticheskaya biomedicinskaya diagnostika. T 1. [Optical biomedical diagnostics. T.1]. Moskw: FizMatLit, 2007, 560 s. (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Rogatkin D.A. Fizicheskie osnovy’ opticheskoy oksimetrii [Physical basis of optical oximetry]. Med fizika, 2012, № 2, pp. 97-114. (in Russian).</mixed-citation><mixed-citation xml:lang="en">Rogatkin D.A. Fizicheskie osnovy’ opticheskoy oksimetrii [Physical basis of optical oximetry]. Med fizika, 2012, № 2, pp. 97-114. (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Drexler W. Cellular and Functional Optical Coherence Tomography of the Human Retina the Cogan Lecture. Invest Ophthalmol Vis Sci, 2007, vol. 48, № 12, pp. 5340-5351.</mixed-citation><mixed-citation xml:lang="en">Drexler W. Cellular and Functional Optical Coherence Tomography of the Human Retina the Cogan Lecture. Invest Ophthalmol Vis Sci, 2007, vol. 48, № 12, pp. 5340-5351.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Palczewski1 K. Silver Anniversary Review Focus on vision: 3 decades of remarkable contributions to biology and medicine. FASEB J 2011, vol. 25, № 2, pp. 439-443.</mixed-citation><mixed-citation xml:lang="en">Palczewski1 K. Silver Anniversary Review Focus on vision: 3 decades of remarkable contributions to biology and medicine. FASEB J 2011, vol. 25, № 2, pp. 439-443.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Cheung C.Y., Ikram M.K., Sabanayagam Ch., Wong T.Y. Retinal Microvasculature as a Model to Study the Manifestations of Hypertension. Hypertension, 2012, vol. 60, № 5, pp. 1094-1103.</mixed-citation><mixed-citation xml:lang="en">Cheung C.Y., Ikram M.K., Sabanayagam Ch., Wong T.Y. Retinal Microvasculature as a Model to Study the Manifestations of Hypertension. Hypertension, 2012, vol. 60, № 5, pp. 1094-1103.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Jacques S.L. Corrigendum: Opticalpropertiesofbiologicaltissues: areview. Phys Med Biol, 2013, vol. 58, pp. 5007.</mixed-citation><mixed-citation xml:lang="en">Jacques S.L. Corrigendum: Opticalpropertiesofbiologicaltissues: areview. Phys Med Biol, 2013, vol. 58, pp. 5007.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Ly’senko S.A., Firago V.A., Kugeyko M.M., Kubarko A.I. Opredelenie strukturno-morfologicheskih parametrov bul’barnoy kon‘yunktivy’ cheloveka po spektram diffuznogo otrajeniya sveta [The definition of structural- morphological parameters of the bulbar conjunctiva of man in the spectra of diffuse reflection of light]. Jurnprikladnoyspektroskopii, 2016, vol. 83, № 4, pp. 606-615. (in Russian).</mixed-citation><mixed-citation xml:lang="en">Ly’senko S.A., Firago V.A., Kugeyko M.M., Kubarko A.I. Opredelenie strukturno-morfologicheskih parametrov bul’barnoy kon‘yunktivy’ cheloveka po spektram diffuznogo otrajeniya sveta [The definition of structural- morphological parameters of the bulbar conjunctiva of man in the spectra of diffuse reflection of light]. Jurnprikladnoyspektroskopii, 2016, vol. 83, № 4, pp. 606-615. (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Nerobeev A. I., Dobrodeev A. S., Maly’hina I.F., Somova M.M., Garelik E.I. Kriterii vy’jivaemosti my’shechny’h loskutov na osnove tkanevoy somaticheskoy oksimetrii [Free muscle flaps survival criteria on the basis of tissue somatic oximetry]. Annaly’ plast, rekonstruktivie'stethirurgii, 2014, № 3, pp. 10-18. (in Russian).</mixed-citation><mixed-citation xml:lang="en">Nerobeev A. I., Dobrodeev A. S., Maly’hina I.F., Somova M.M., Garelik E.I. Kriterii vy’jivaemosti my’shechny’h loskutov na osnove tkanevoy somaticheskoy oksimetrii [Free muscle flaps survival criteria on the basis of tissue somatic oximetry]. Annaly’ plast, rekonstruktivie'stethirurgii, 2014, № 3, pp. 10-18. (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Maly’hina I.F., Nerobeev A.I., Dobrodeev A.S., Verbo E.V., Garelik E.I., Salihov K.S. Tkanevaya oksimetriya: ocenka jiznesposobnosti svobodny’h loskutov pri rekonstrukcii [Tissue Oximetry: Monitoring of Microsurgical Freetissue Transfers for Head and Neck Reconstruction]. Vopr rekonstruktiv ipiasthirurgii, 2015, vol. 18, № 2, pp. 11-24. (in Russian).</mixed-citation><mixed-citation xml:lang="en">Maly’hina I.F., Nerobeev A.I., Dobrodeev A.S., Verbo E.V., Garelik E.I., Salihov K.S. Tkanevaya oksimetriya: ocenka jiznesposobnosti svobodny’h loskutov pri rekonstrukcii [Tissue Oximetry: Monitoring of Microsurgical Freetissue Transfers for Head and Neck Reconstruction]. Vopr rekonstruktiv ipiasthirurgii, 2015, vol. 18, № 2, pp. 11-24. (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Pinto M., Barjas-Castro M. L., Nascimenti S. The new noninvasive occlusion spectroscopy hemoglobin measurement method: a reliable and easy anemia screening test for blood donors. Transfusion, 2013, vol. 53, pp. 766-769.</mixed-citation><mixed-citation xml:lang="en">Pinto M., Barjas-Castro M. L., Nascimenti S. The new noninvasive occlusion spectroscopy hemoglobin measurement method: a reliable and easy anemia screening test for blood donors. Transfusion, 2013, vol. 53, pp. 766-769.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Lima A., van Bommel J., Sikorska K., van Genderen M., Klijn E., Lesaffre E., Ince C., Bakker J. The relation of near-infrared spectroscopy with changes in peripheral circulation in critically ill patients. Crit Care Med, 2011, vol. 39, № 7, pp. 1649-1654. doi: 10.1097/CCM.0b013e3182186675.</mixed-citation><mixed-citation xml:lang="en">Lima A., van Bommel J., Sikorska K., van Genderen M., Klijn E., Lesaffre E., Ince C., Bakker J. The relation of near-infrared spectroscopy with changes in peripheral circulation in critically ill patients. Crit Care Med, 2011, vol. 39, № 7, pp. 1649-1654. doi: 10.1097/CCM.0b013e3182186675.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Liasi F.T., Samatham R., Jacques S.L. Noninvasive in vivo optical characterization of blood flow and oxygen consumption in the superficial plexus of skin. JBiomed Opt, 2017, vol. 22, № 11, pp. 1-6. doi: 10.1117/ 1.JBO.22.11.115002.</mixed-citation><mixed-citation xml:lang="en">Liasi F.T., Samatham R., Jacques S.L. Noninvasive in vivo optical characterization of blood flow and oxygen consumption in the superficial plexus of skin. JBiomed Opt, 2017, vol. 22, № 11, pp. 1-6. doi: 10.1117/ 1.JBO.22.11.115002.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Dunaev A.V., Rogatkin D.A. K voprosu o vozmojnosti ispol’zovaniya metodov neinvazivnoy spektrofotometrii dlya kontrolya e‘ffektivnosti nizkointensivnoy lazernoy terapii [To question of possibility to use methods of non-invasive spectrophometry for controlling the effectiveness of the low level laser therapy]. Fundam i priklad problemy’ tehniki I tehnoiogii, 2009, № 3, pp. 110-115. (in Russian).</mixed-citation><mixed-citation xml:lang="en">Dunaev A.V., Rogatkin D.A. K voprosu o vozmojnosti ispol’zovaniya metodov neinvazivnoy spektrofotometrii dlya kontrolya e‘ffektivnosti nizkointensivnoy lazernoy terapii [To question of possibility to use methods of non-invasive spectrophometry for controlling the effectiveness of the low level laser therapy]. Fundam i priklad problemy’ tehniki I tehnoiogii, 2009, № 3, pp. 110-115. (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Stromblad S. Measuring the Optical Properties o f Human Muscle Tissue using Time-of-Flight Spectroscopy in the Near Infrared: Magist. diss. Lund University Faculty of Engineering. LTH, 2015, 45 p.</mixed-citation><mixed-citation xml:lang="en">Stromblad S. Measuring the Optical Properties o f Human Muscle Tissue using Time-of-Flight Spectroscopy in the Near Infrared: Magist. diss. Lund University Faculty of Engineering. LTH, 2015, 45 p.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Wang W., Winlove C.P., Michel C.C. Oxygen partial pressure in outer layers of skin of human finger nail folds. J Physiol, 2003, vol. 549, № 3, pp. 855-863. doi: 10.1113/jphysiol.2002.037994.</mixed-citation><mixed-citation xml:lang="en">Wang W., Winlove C.P., Michel C.C. Oxygen partial pressure in outer layers of skin of human finger nail folds. J Physiol, 2003, vol. 549, № 3, pp. 855-863. doi: 10.1113/jphysiol.2002.037994.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Ly’senko S. A. Operativnaya diagnostika bioob'ektovpo spektral’noprostranstvenny’m harakteristikam ih svetorasseyaniya [Operative diagnostics of biological objects by spectral-spatial characteristics of their light scattering]: Avtoref. diss. d-ra. fiz.-mat. nauk : 01.04.05. Minsk, BGU, 2017, 46 s. (in Russian).</mixed-citation><mixed-citation xml:lang="en">Ly’senko S. A. Operativnaya diagnostika bioob'ektovpo spektral’noprostranstvenny’m harakteristikam ih svetorasseyaniya [Operative diagnostics of biological objects by spectral-spatial characteristics of their light scattering]: Avtoref. diss. d-ra. fiz.-mat. nauk : 01.04.05. Minsk, BGU, 2017, 46 s. (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Krog A. Anatomiya i fiziologiya kapillyarov [The anatomy and physiology of capillaries]. M.: Moszdravotdel, 1927, 184 p. (in Russian).</mixed-citation><mixed-citation xml:lang="en">Krog A. Anatomiya i fiziologiya kapillyarov [The anatomy and physiology of capillaries]. M.: Moszdravotdel, 1927, 184 p. (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Svaasand L.O., Norwang L.T., Fiskerstrand E.J., Stopps E.K.S., Berns M.W., Nelson J.S. Tissue parameters determining the visual appearance of normal skin and port-wine stans. Laser Med Sci, 1995, vol. 10, pp. 55-65. doi: 10.1007/bf02133165.</mixed-citation><mixed-citation xml:lang="en">Svaasand L.O., Norwang L.T., Fiskerstrand E.J., Stopps E.K.S., Berns M.W., Nelson J.S. Tissue parameters determining the visual appearance of normal skin and port-wine stans. Laser Med Sci, 1995, vol. 10, pp. 55-65. doi: 10.1007/bf02133165.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Gayton A.K., Holl E. Medicinskaya fiziologiya [Medical physiology]. M.: Logosfera, 2008, 1296 s. (in Russian).</mixed-citation><mixed-citation xml:lang="en">Gayton A.K., Holl E. Medicinskaya fiziologiya [Medical physiology]. M.: Logosfera, 2008, 1296 s. (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Marchal G., Young A.R., Baron J-C. Early Postischemic Hyperperfusion: Pathophysiologic Insights From Positron Emission Tomography. J Cereb Blood Flow Metab, 1999, № 19, p. 467-482.</mixed-citation><mixed-citation xml:lang="en">Marchal G., Young A.R., Baron J-C. Early Postischemic Hyperperfusion: Pathophysiologic Insights From Positron Emission Tomography. J Cereb Blood Flow Metab, 1999, № 19, p. 467-482.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Tkachenko B.I. eds. Fiziologiya krovoobrasch’eniya: fiziologiya sosudistoy sistemy’ [Physiology of blood circulation: physiology of the vascular system]. L. : Nauka, 1984, 652 s. (in Russian).</mixed-citation><mixed-citation xml:lang="en">Tkachenko B.I. eds. Fiziologiya krovoobrasch’eniya: fiziologiya sosudistoy sistemy’ [Physiology of blood circulation: physiology of the vascular system]. L. : Nauka, 1984, 652 s. (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Jaszczak P. Skin oxygen tension, skin oxygen consumption, and skin blood flow measured by a tc-pO2 electrode. Acta PhysiolScandSupplJ991, № 603, pp. 53-57.</mixed-citation><mixed-citation xml:lang="en">Jaszczak P. Skin oxygen tension, skin oxygen consumption, and skin blood flow measured by a tc-pO2 electrode. Acta PhysiolScandSupplJ991, № 603, pp. 53-57.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Grundman A., Ludders D.W. The determination of the O2-consumption of the skin by the measurement of the decrease of the skin surface PO2 after flow stop using an optical O2-stnsor without O2-consumption : a theoretical analysis. Grote J., Witzleb eds. Regulation of blood flow and tissue oxygen supply. Verlag, 1994, pp. 265-270.</mixed-citation><mixed-citation xml:lang="en">Grundman A., Ludders D.W. The determination of the O2-consumption of the skin by the measurement of the decrease of the skin surface PO2 after flow stop using an optical O2-stnsor without O2-consumption : a theoretical analysis. Grote J., Witzleb eds. Regulation of blood flow and tissue oxygen supply. Verlag, 1994, pp. 265-270.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Jensen-Kondering U., Baron J-C. Oxygen Imaging by MRI: Can Blood Oxygen Level-Dependent Imaging Depict theIschemic Penumbra? Stroke, 2012, vol. 43, № 8, pp. 2264-2269. doi: 10.1161/STROKEAHA.111.632455.</mixed-citation><mixed-citation xml:lang="en">Jensen-Kondering U., Baron J-C. Oxygen Imaging by MRI: Can Blood Oxygen Level-Dependent Imaging Depict theIschemic Penumbra? Stroke, 2012, vol. 43, № 8, pp. 2264-2269. doi: 10.1161/STROKEAHA.111.632455.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Pal’cev M.A., Anichkov N.M. Patologicheskaya anatomiya. T. 1: Obsch’iy kurs [Pathological anatomy. Vol. 1: General course.]. M.: Medicina, 2001, 528 s. (in Russian).</mixed-citation><mixed-citation xml:lang="en">Pal’cev M.A., Anichkov N.M. Patologicheskaya anatomiya. T. 1: Obsch’iy kurs [Pathological anatomy. Vol. 1: General course.]. M.: Medicina, 2001, 528 s. (in Russian).</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
