<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">emcardio</journal-id><journal-title-group><journal-title xml:lang="ru">Неотложная кардиология и кардиоваскулярные риски</journal-title><trans-title-group xml:lang="en"><trans-title>Emergency Cardiology and Cardiovascular Risks journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2616-633X</issn><publisher><publisher-name>Белорусский государственный медицинский университет</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">emcardio-242</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Обзоры и лекции</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Reviews and lectures</subject></subj-group></article-categories><title-group><article-title>Возможности атомносиловой микроскопии в изучении структурно-функциональных свойств клеток крови при остром коронарном синдроме</article-title><trans-title-group xml:lang="en"><trans-title>Possibilities of atomic force microscopy in studying the structural and functional properties of blood cells in acute coronary syndrome</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Цапаева</surname><given-names>Н. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Tsapayeva</surname><given-names>N. L.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Миронова</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Mironova</surname><given-names>E. V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чижик</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Chizik</surname><given-names>A. S.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мельникова</surname><given-names>Г. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Melnikova</surname><given-names>G. V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Толстая</surname><given-names>Т. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Tolstaya</surname><given-names>T. N.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Черноглаз</surname><given-names>П. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Chernoglaz</surname><given-names>P. F.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Юрлевич</surname><given-names>Д. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Yurlevich</surname><given-names>D. I.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>Белорусский государственный медицинский университет</institution><country>Belarus</country></aff><aff xml:lang="ru" id="aff-2"><institution>Институт тепло- и массообмена им. А.В.Лыкова НАН Беларуси</institution><country>Belarus</country></aff><aff xml:lang="ru" id="aff-3"><institution>Учреждение здравоохранения «1-я городская клиническая больница»</institution><country>Belarus</country></aff><aff xml:lang="ru" id="aff-4"><institution>ГУ «Минский научно-практический центр хирургии, трансплантологии и гематологии»</institution><country>Belarus</country></aff><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>12</day><month>11</month><year>2025</year></pub-date><volume>3</volume><issue>1</issue><elocation-id>568–575</elocation-id><permissions><copyright-statement>Copyright &amp;#x00A9; Цапаева Н.Л., Миронова Е.В., Чижик С.А., Мельникова Г.Б., Толстая Т.Н., Черноглаз П.Ф., Юрлевич Д.И., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Цапаева Н.Л., Миронова Е.В., Чижик С.А., Мельникова Г.Б., Толстая Т.Н., Черноглаз П.Ф., Юрлевич Д.И.</copyright-holder><copyright-holder xml:lang="en">Tsapayeva N.L., Mironova E.V., Chizik A.S., Melnikova G.V., Tolstaya T.N., Chernoglaz P.F., Yurlevich D.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://emcardio.bsmu.by/jour/article/view/242">https://emcardio.bsmu.by/jour/article/view/242</self-uri><abstract><p>В статье изучены структурно-функциональные особенности тромбоцитов и эритроцитов в патогенезе острого коронарного повреждения миокарда и их изменения у пациентов с острым коронарным синдромом (ОКС) в течение трёх лет наблюдения.</p></abstract><trans-abstract xml:lang="en"><p>To study structural and functional characteristics of platelets and erythrocytes in the pathogenesis of acute coronary injury of the myocardium in patients with acute coronary syndrome within three years.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>острый коронарный синдром</kwd><kwd>атомно-силовая микроскопия</kwd><kwd>структурно-функциональные свойства эритроцитов и тромбоцитов</kwd><kwd>двойная анитромбоцитарная терапия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>acute coronary syndrome</kwd><kwd>atomic force microscopy</kwd><kwd>structural and mechanical properties of erythrocytes and platelets</kwd><kwd>dual antiplatelet therapy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Wijns W., Kolh P., Danchin N., Di Mario C., Falk V., Folliguet T., Garg S., Huber K., James S., Knuuti J., Lopez-Sendon J., Marco J., Menicanti L., Ostojic M., Piepoli M.F., Pirlet C., Pomar J.L., Reifart N., Ribichini F.L., Schalij M.J., Sergeant P., Serruys P.W., Silber S., Sousa U.M., Taggart D. Guidelines on myocardial revascularization: The Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS). Eur Heart J. 2014, vol. 31, no. 20, pp. 2501–2555. doi: 10.1093/eurheartj/ehq277.</mixed-citation><mixed-citation xml:lang="en">Wijns W., Kolh P., Danchin N., Di Mario C., Falk V., Folliguet T., Garg S., Huber K., James S., Knuuti J., Lopez-Sendon J., Marco J., Menicanti L., Ostojic M., Piepoli M.F., Pirlet C., Pomar J.L., Reifart N., Ribichini F.L., Schalij M.J., Sergeant P., Serruys P.W., Silber S., Sousa U.M., Taggart D. Guidelines on myocardial revascularization: The Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS). Eur Heart J. 2014, vol. 31, no. 20, pp. 2501–2555. doi: 10.1093/eurheartj/ehq277.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Widimsky P., Fajadet J., Danchin N., Wijns W. «Stent 4 Life» targeting PCI at all who will benefit the most. A joint project between EAPCI, Euro–PCR, EUCOMED and the ESC Working Group on Acute Cardiac Care. EuroIntervention, 2009, vol. 4, no. 5, pp. 555–557.</mixed-citation><mixed-citation xml:lang="en">Widimsky P., Fajadet J., Danchin N., Wijns W. «Stent 4 Life» targeting PCI at all who will benefit the most. A joint project between EAPCI, Euro–PCR, EUCOMED and the ESC Working Group on Acute Cardiac Care. EuroIntervention, 2009, vol. 4, no. 5, pp. 555–557.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Konstantinova E., Tsapaeva N, Mironova E. Changes of the microcirculation state and the hemorheology parameters in acute coronary syndrome. 13th Conference of the European Society for Clinical Hemorheology, Siena, Italy, June 26–29, 2005 : abstract book. Siena, 2005, pp. 39–41.</mixed-citation><mixed-citation xml:lang="en">Konstantinova E., Tsapaeva N, Mironova E. Changes of the microcirculation state and the hemorheology parameters in acute coronary syndrome. 13th Conference of the European Society for Clinical Hemorheology, Siena, Italy, June 26–29, 2005 : abstract book. Siena, 2005, pp. 39–41.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Тsapaeva N. Microcurculatory and haemorhelogical disorders in patients with IHD with differents anatomic and functional status of collateral blood flow. Abstracts of XVIII ESC and FSC, Paris, Junier 16–19, 2008. Paris, 2008, pp. 245–246.</mixed-citation><mixed-citation xml:lang="en">Тsapaeva N. Microcurculatory and haemorhelogical disorders in patients with IHD with differents anatomic and functional status of collateral blood flow. Abstracts of XVIII ESC and FSC, Paris, Junier 16–19, 2008. Paris, 2008, pp. 245–246.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Kuznetsova T., Starodubtseva M., Yegorenkov N., Chizhik S., Zhdanov R. Atomic force microscopy probing of cell elasticity. Micron, 2007, vol. 38, no. 8, pp. 824–833.</mixed-citation><mixed-citation xml:lang="en">Kuznetsova T., Starodubtseva M., Yegorenkov N., Chizhik S., Zhdanov R. Atomic force microscopy probing of cell elasticity. Micron, 2007, vol. 38, no. 8, pp. 824–833.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Sirghi L., Ponti J., Broggi F., Rossi F. Probing elasticity and adhesion of live cells by atomic force microscopy indentation. Eur Biophys J, 2008, vol. 37, no. 6, pp. 935–945.</mixed-citation><mixed-citation xml:lang="en">Sirghi L., Ponti J., Broggi F., Rossi F. Probing elasticity and adhesion of live cells by atomic force microscopy indentation. Eur Biophys J, 2008, vol. 37, no. 6, pp. 935–945.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Jin H., Xing X., Zhao H., Chen Y., Huang X., Ma S., Ye H., Cai J. Detection of erythrocytes influenced by aging and type 2 diabetes using atomic force microscope. Biochem Biophys Res Commun. 2010, vol. 391, no. 4, pp. 1698–1702.</mixed-citation><mixed-citation xml:lang="en">Jin H., Xing X., Zhao H., Chen Y., Huang X., Ma S., Ye H., Cai J. Detection of erythrocytes influenced by aging and type 2 diabetes using atomic force microscope. Biochem Biophys Res Commun. 2010, vol. 391, no. 4, pp. 1698–1702.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">ICSH recommendations for measurement of erythrocyte sedimentation rate. International Council for Standardization in Haematology (Expert Panel on Blood Rheology).J Clin Pathol, 1993, vol. 46, no. 3, pp. 198–203.</mixed-citation><mixed-citation xml:lang="en">ICSH recommendations for measurement of erythrocyte sedimentation rate. International Council for Standardization in Haematology (Expert Panel on Blood Rheology).J Clin Pathol, 1993, vol. 46, no. 3, pp. 198–203.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Zapaeva N.L., Russkich I.I., Chernoglaz P.F., Yurlevich D.I., Mironova E.V., Zhuk O.I., Kolb M.V. Моnitoring dvojnoj antitrombozitarnoj terapii posle ekstrennoj revascularisazii miokarda u pazientov s ostrim koronarnim sindromom [Monitoring of dual antiplatelet therapy after emergency myocardial revascularization in patients with acute coronary syndrome]. I Meszdunardnij congress kardiologov i terapevtov : sb. nauch. trudov. Minsk, 2016, pp. 313–318. (in Russian).</mixed-citation><mixed-citation xml:lang="en">Zapaeva N.L., Russkich I.I., Chernoglaz P.F., Yurlevich D.I., Mironova E.V., Zhuk O.I., Kolb M.V. Моnitoring dvojnoj antitrombozitarnoj terapii posle ekstrennoj revascularisazii miokarda u pazientov s ostrim koronarnim sindromom [Monitoring of dual antiplatelet therapy after emergency myocardial revascularization in patients with acute coronary syndrome]. I Meszdunardnij congress kardiologov i terapevtov : sb. nauch. trudov. Minsk, 2016, pp. 313–318. (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Konstantinova E., Tsapaeva N., Mironova E. Structural and mechanical propertiesof erythrocytes and platelets in patients with acute coronary syndrome. 6 th Eurosummer school on Biorheology and Symposium on Micro and Mechanobiology of cells, tissues and systems: book abstracts. Varna, 2018, pp. 53–54.</mixed-citation><mixed-citation xml:lang="en">Konstantinova E., Tsapaeva N., Mironova E. Structural and mechanical propertiesof erythrocytes and platelets in patients with acute coronary syndrome. 6 th Eurosummer school on Biorheology and Symposium on Micro and Mechanobiology of cells, tissues and systems: book abstracts. Varna, 2018, pp. 53–54.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Arking D.E., Junttila M.J., Goyette P., Huertas-Vazquez A., Eijgelsheim M., Blom M.T., Newton-Cheh C., Reinier K., Teodorescu C., Uy-Evanado A., Carter-Monroe N., Kaikkonen K.S., Kortelainen M.L., Boucher G., Lagacé C., Moes A., Zhao X., Kolodgie F., Rivadeneira F. et al. Identification of a Sudden Cardiac Death Susceptibility Locus at 2q24.2 through Genome-Wide Association in European Ancestry Individuals. PLoS Genet. 2011. vol. 7, no. 6. e1002158. doi: 10.1371/journal.pgen.1002158.</mixed-citation><mixed-citation xml:lang="en">Arking D.E., Junttila M.J., Goyette P., Huertas-Vazquez A., Eijgelsheim M., Blom M.T., Newton-Cheh C., Reinier K., Teodorescu C., Uy-Evanado A., Carter-Monroe N., Kaikkonen K.S., Kortelainen M.L., Boucher G., Lagacé C., Moes A., Zhao X., Kolodgie F., Rivadeneira F. et al. Identification of a Sudden Cardiac Death Susceptibility Locus at 2q24.2 through Genome-Wide Association in European Ancestry Individuals. PLoS Genet. 2011. vol. 7, no. 6. e1002158. doi: 10.1371/journal.pgen.1002158.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Kuliczkowski W., Witkowski A., Polonski L., Watala C., Filipiak K., Budaj A., Golanski J., Sitkiewicz D., Pregowski J., Gorski J., Zembala M., Opolski G., Huber K., Arnesen H., Kristensen S.D., De Caterina R. Interindividual variability in the response to oral antiplatelet drugs: a position paper of the Working Group on antiplatelet drugs resistance appointed by the Section of Cardiovascular Interventions of the Polish Cardiac Society, endorsed by the Working Group on Thrombosis of the European Society of Cardiology. Eur Heart J, 2009, vol. 30, no. 4, pp. 426–435.</mixed-citation><mixed-citation xml:lang="en">Kuliczkowski W., Witkowski A., Polonski L., Watala C., Filipiak K., Budaj A., Golanski J., Sitkiewicz D., Pregowski J., Gorski J., Zembala M., Opolski G., Huber K., Arnesen H., Kristensen S.D., De Caterina R. Interindividual variability in the response to oral antiplatelet drugs: a position paper of the Working Group on antiplatelet drugs resistance appointed by the Section of Cardiovascular Interventions of the Polish Cardiac Society, endorsed by the Working Group on Thrombosis of the European Society of Cardiology. Eur Heart J, 2009, vol. 30, no. 4, pp. 426–435.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
