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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">emcardio</journal-id><journal-title-group><journal-title xml:lang="ru">Неотложная кардиология и кардиоваскулярные риски</journal-title><trans-title-group xml:lang="en"><trans-title>Emergency Cardiology and Cardiovascular Risks journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2616-633X</issn><publisher><publisher-name>Белорусский государственный медицинский университет</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">emcardio-233</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Оригинальные научные публикации</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Original Scientific Research</subject></subj-group></article-categories><title-group><article-title>Нешегреновская болезнь сухого глаза в общеврачебной практике: причины, исходы, тактика</article-title><trans-title-group xml:lang="en"><trans-title>Non-sjögren syndrome dry eye in general medical practice: causes, outcomes, treatment tactics</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Семак</surname><given-names>Г. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Semak</surname><given-names>G. R.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Захарова</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Zaharava</surname><given-names>V. A.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Клецкий</surname><given-names>С. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Kletsky</surname><given-names>S. K.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Летковская</surname><given-names>Т. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Liatkovskaya</surname><given-names>T. A.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Жерко</surname><given-names>И. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Zherko</surname><given-names>I. Yu.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>УО «Белорусский государственный медицинский университет»</institution></aff><aff xml:lang="en"><institution>Belarusian State Medical University</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>11</day><month>11</month><year>2025</year></pub-date><volume>3</volume><issue>2</issue><elocation-id>719–725</elocation-id><permissions><copyright-statement>Copyright &amp;#x00A9; Семак Г.Р., Захарова В.А., Клецкий С.К., Летковская Т.А., Жерко И.Ю., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Семак Г.Р., Захарова В.А., Клецкий С.К., Летковская Т.А., Жерко И.Ю.</copyright-holder><copyright-holder xml:lang="en">Semak G.R., Zaharava V.A., Kletsky S.K., Liatkovskaya T.A., Zherko I.Y.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://emcardio.bsmu.by/jour/article/view/233">https://emcardio.bsmu.by/jour/article/view/233</self-uri><abstract><p>В последние годы все большую актуальность в практике терапевтической службы приобретает синдром «сухого глаза», в Республике Беларусь около 17–25% населения после 40 лет страдает роговично-конъюнктивальным ксерозом различной степени выраженности. Нешегреновская болезнь сухого глаза (БСГ) может развиваться как в исходе заболеваний глаз, так и на фоне общесоматической патологии (сахарный диабет, системный атеросклероз, климактерический синдром, артериальная гипертензия, болезни щитовидной железы, метаболический синдром), часто связаны с применяемыми системно и местно лекарственными препаратами (β-блокаторы, диуретики, анальгетики, антидепрессанты и др.). При прогрессировании дистрофии роговицы и формировании бельм применяются различные виды кератопластики донорской роговицы. Частота 5-летней выживаемости трансплантата на фоне дефицита слезной пленки в лучших клиниках составляет менее 50%.</p></abstract><trans-abstract xml:lang="en"><p>Recently, non-Sjogren’s eye disease (DED) has become increasingly frequent in the therapeutic practice. In the Republic of Belarus, about 17–25% of the population over 40 years old suffer from corneal conjunctival xerosis of various severity. DED can develop both as an outcome of eye diseases and on the background of somatic pathology (diabetes mellitus, systemic atherosclerosis, menopausal syndrome, arterial hypertension, thyroid disease and metabolic syndrome) and is often associated with the systemic and topical use of medications (β-blockers, diuretics, analgesics, antidepressants, etc.). With the progression of corneal dystrophy and albugo formation, various types of donor cornea keratoplasty are used. In the best clinics, a 5-year transplant survival associated with the tear film deficiency is less than 50%.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>болезнь сухого глаза</kwd><kwd>синдром Шегрена</kwd><kwd>кератопластика</kwd><kwd>гиалуроновая кислота</kwd><kwd>регенерация</kwd><kwd>коморбидный пациент</kwd></kwd-group><kwd-group xml:lang="en"><kwd>dry eye disease</kwd><kwd>Sjogren syndrome</kwd><kwd>keratoplasty</kwd><kwd>hyaluronic acid</kwd><kwd>regeneration</kwd><kwd>comorbid patient</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Onishenko A.L., Kolbasko A.V., Safronova M.A. Rasprostranennost’ i struktura oftal’mopatologii [The incidence and structure of ophthalmopathology of tubalars]. Oftal’mologiya, 2017, no. 14(4), pp. 375–380. (in Russian).</mixed-citation><mixed-citation xml:lang="en">Onishenko A.L., Kolbasko A.V., Safronova M.A. Rasprostranennost’ i struktura oftal’mopatologii [The incidence and structure of ophthalmopathology of tubalars]. Oftal’mologiya, 2017, no. 14(4), pp. 375–380. (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Nelson J.D., Craig J.P., Akpek E.K., Azar D.T., Belmonte C., Bron A.J., Clayton J.A., Dogru M., Dua H.S., Foulks G.N., Gomes J.A. et al. TFOS DEWS II Introduction. Ocul Surf, 2017, vol. 15, no. 3, pp. 269–275. doi: 10.1016/j.jtos.2017.05.005.</mixed-citation><mixed-citation xml:lang="en">Nelson J.D., Craig J.P., Akpek E.K., Azar D.T., Belmonte C., Bron A.J., Clayton J.A., Dogru M., Dua H.S., Foulks G.N., Gomes J.A. et al. TFOS DEWS II Introduction. Ocul Surf, 2017, vol. 15, no. 3, pp. 269–275. doi: 10.1016/j.jtos.2017.05.005.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Ament J.D., Todani A., Pineda R. 2nd, Shen T.T., Aldave A.J., Dohlman C.H., Chodosh J. Global Corneal Blindness and the Boston Keratoprosthesis Type I. Am J Ophthalmol, 2010, vol. 149, no. 4, pp. 537–539.</mixed-citation><mixed-citation xml:lang="en">Ament J.D., Todani A., Pineda R. 2nd, Shen T.T., Aldave A.J., Dohlman C.H., Chodosh J. Global Corneal Blindness and the Boston Keratoprosthesis Type I. Am J Ophthalmol, 2010, vol. 149, no. 4, pp. 537–539.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Somov E.E., Brzheskiy V.V. Diagnostika i lechenie bol’nych s sindromom «suchogo glaza»: kratkoe rukovodstvo dlya vrachey [Diagnosis and treatment of patients with dry eye syndrome: a brief guide for doctors]. SPb., 2010. pp. 11–22. (in Russian).</mixed-citation><mixed-citation xml:lang="en">Somov E.E., Brzheskiy V.V. Diagnostika i lechenie bol’nych s sindromom «suchogo glaza»: kratkoe rukovodstvo dlya vrachey [Diagnosis and treatment of patients with dry eye syndrome: a brief guide for doctors]. SPb., 2010. pp. 11–22. (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">McCarey B.E., Edelhauser H.F., Lynn M.J. Review of corneal endothelial specular microscopy for FDA clinical trials of refractive procedures, surgical devices, and new intraocular drugs and solutions. Cornea, 2008, vol. 27, no. 1, pp. 1–16. doi: 10.1097/ ICO.0b013e31815892da.</mixed-citation><mixed-citation xml:lang="en">McCarey B.E., Edelhauser H.F., Lynn M.J. Review of corneal endothelial specular microscopy for FDA clinical trials of refractive procedures, surgical devices, and new intraocular drugs and solutions. Cornea, 2008, vol. 27, no. 1, pp. 1–16. doi: 10.1097/ ICO.0b013e31815892da.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
