References

emcardio

Неотложная кардиология и кардиоваскулярные риски

Emergency Cardiology and Cardiovascular Risks journal

2616-633X

Белорусский государственный медицинский университет

10.51922/2616-633X.2023.7.2.2000

emcardio-23

Research Article

Обзоры и лекции

Reviews and lectures

Перспективы атомно-силовой микроскопии в изучении патологических процессов у пациентов кардиологического профиля

Prospects of atomic force microscopy in studying pathological processes in cardiological patients

Бируля

А. А.

Birulya

A. A.

г. Минск

Minsk

koloboma@list.ru

Казакова

М. И.

Kazakova

M. I.

г. Минск

Minsk

Мельникова

Г. Б.

Melnikova

G. B.

г. Минск

Minsk

Петрова

Е. Б.

Petrova

E. B.

г. Минск

Minsk

Чижик

С. А.

Chizhik

S. A.

г. Минск

Minsk

Митьковская

Н. П.

Mitkovskaya

N. P.

г. Минск

Minsk

Учреждение образования «Белорусский государственный медицинский университет»; Республиканский научно-практический центр «Кардиология»Belarusian State Medical University; Scientific and practical centre «Cardiology»

Учреждение образования «Белорусский государственный медицинский университет»; Республиканский клинический медицинский центр Управления делами Президента Республики БеларусьBelarusian State Medical University; Republican Clinical Medical Center of the Presidential Administration of the Republic of Belarus

Государственное научное учреждение «Институт тепло- и массообмена имени А.В. Лыкова Национальной академии наук Беларуси»A.V. Luikov Heat and Mass Transfer Institute of the National Academy of Sciences of Belarus

2023

19062025

7220002008

2025

Бируля А.А., Казакова М.И., Мельникова Г.Б., Петрова Е.Б., Чижик С.А., Митьковская Н.П.

Birulya A.A., Kazakova M.I., Melnikova G.B., Petrova E.B., Chizhik S.A., Mitkovskaya N.P.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://emcardio.bsmu.by/jour/article/view/23

Во всем мире вопросу изучения фундаментальных клеточных процессов посвящены многочисленные изыскания. Развитие новых методов исследований с высокой разрешающей способностью сделало возможным изучение патологических процессов на микро- и наноуровне. Атомно-силовая микроскопия – один из перспективных методов получения качественной и количественной информации о патологических состояниях, основанный на анализе топографии поверхности (размеров, шероховатости) и локальных механических свойств (модуля упругости, силы адгезии, трибологических характеристик) структурных элементов клеток и тканей. В статье кратко описан принцип работы метода и возможности его применения в различных областях медицины (терапии, онкологии, офтальмологии, трансфузиологии, стоматологии и др.). Подробно представлена роль форменных элементов крови (эритроциты, тромбоциты) в патогенезе заболеваний у пациентов кардиологического профиля. Рассмотрены возможности метода в изучении характеристик атеросклеротической бляшки в коронарных артериях на разных этапах атерогенеза.

Numerous studies have been devoted to the study of fundamental cellular processes all over the world. The development of new research methods with high resolution has made it possible to study pathological processes at the micro and nanoscale. Atomic force microscopy is one of the promising methods for obtaining qualitative and quantitative information about pathological conditions, based on the analysis of surface topography (dimensions, roughness) and local mechanical properties (modulus of elasticity, adhesion strength, tribological properties) of structural elements of cells and tissues. The article briefly describes the principle of operation of the method and the possibilities of its application in various fields of medicine (therapy, oncology, ophthalmology, transfusiology, dentistry, etc.). The role of shaped blood elements (erythrocytes, platelets) in the pathogenesis of cardiological diseases is presented in detail. The possibilities of the method in studying the characteristics of atherosclerotic plaque in coronary arteries at different stages of atherogenesis are considered.

микроциркуляцияишемическая болезнь сердцаатеросклеротическая бляшкаформенные элементы крови

microcirculationischemic heart diseaseatherosclerotic plaqueblood cells

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The authors declare that there are no conflicts of interest present.