emcardioНеотложная кардиология и кардиоваскулярные рискиEmergency Cardiology and Cardiovascular Risks journal2616-633XБелорусский государственный медицинский университетemcardio-229Research ArticleОригинальные научные публикацииOriginal Scientific ResearchУровень гомоцистеина и полиморфизмы генов фолатного обмена у пациентов с ишемической болезнью сердца и сахарным диабетом 2 типаThe level of homocysteine and polymorphisms of genes of folate exchange in patients with coronary heart disease and diabetes mellitus type 2ДавыдчикЭ. В.DavydchykE. V.СнежицкийВ. А.SnezhitskiyV. A.СтепуроТ. Л.StepuroT. L.ДорошенкоЕ. М.DoroshenkoE. M.СмирновВ. Ю.SmirnovV. Yu.УО «Гродненский государственный медицинский университет»Educational Institution «Grodno State Medical University»ГП «Институт биохимии биологически активных соединений НАН Беларуси»Institute of Biochemistry of Biologically Active Compounds of the NAS of Belarus20191111202532690–696Copyright © Давыдчик Э.В., Снежицкий В.А., Степуро Т.Л., Дорошенко Е.М., Смирнов В.Ю., 20252025Давыдчик Э.В., Снежицкий В.А., Степуро Т.Л., Дорошенко Е.М., Смирнов В.Ю.Davydchyk E.V., Snezhitskiy V.A., Stepuro T.L., Doroshenko E.M., Smirnov V.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://emcardio.bsmu.by/jour/article/view/229

Цель исследования. Изучить уровень гомоцистеина (Нсу), распределение частот генотипов и аллелей полиморфных вариантов С677Т, А1298С гена метилентетрагидрофолатредуктазы (MTHFR), A66G гена метионинсинтазы-редуктазы (MTRR), А2756G гена метионинсинтазы (MTR) у пациентов с хронической ишемической болезнью сердца (ИБС) в сочетании с сахарным диабетом (СД) 2 типа.

The aim of the study is to investigate the level of homocysteine (Hcy), distribution of frequencies of alleles and genotypes of polymorphic options С677Т, А1298С of gene MTHFR, A66G of gene MTRR, А2756G of gene MTR in patients with chronic coronary heart disease (CHD) in combination with diabetes mellitus (DM) type 2.

ишемическая болезнь сердцасахарный диабет 2 типагомоцистеинполиморфные варианты С677ТА1298С гена метилентетрагидрофолатредуктазыА66G гена метионинсинтазы-редуктазыА2756G гена метионинсинтазыcoronary heart diseasediabetes mellitus type 2homocysteinepolymorphic options С677ТА1298С of gene MTHFRA66G of gene MTRRА2756G of gene MTRReferencesSnezhizkiy V.A., Pyrochkin A.V., Spas V.V., Doroshenko E.M., Egorova T.Yu., Mironchik EV., Naumov A.V., Yakubzevich R.E., Zuchovizkaya E.V., Plozkiy A.R., Yanushko T.V., Volod’ko Yu.S. Pizko D.V., Predko V.A., Deshko M.S. Klinicheskie aspekti gipergomotsisteinemii [Clinical aspects of hyperhomocysteinemia]. Grodno: GSMU, 2011, 291 р. (in Russian).Snezhizkiy V.A., Pyrochkin A.V., Spas V.V., Doroshenko E.M., Egorova T.Yu., Mironchik EV., Naumov A.V., Yakubzevich R.E., Zuchovizkaya E.V., Plozkiy A.R., Yanushko T.V., Volod’ko Yu.S. Pizko D.V., Predko V.A., Deshko M.S. Klinicheskie aspekti gipergomotsisteinemii [Clinical aspects of hyperhomocysteinemia]. 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The authors declare that there are no conflicts of interest present.