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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">emcardio</journal-id><journal-title-group><journal-title xml:lang="ru">Неотложная кардиология и кардиоваскулярные риски</journal-title><trans-title-group xml:lang="en"><trans-title>Emergency Cardiology and Cardiovascular Risks journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2616-633X</issn><publisher><publisher-name>Белорусский государственный медицинский университет</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">emcardio-219</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Мастер-класс</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Master-class</subject></subj-group></article-categories><title-group><article-title>Хронические коронарные синдромы: обзор рекомендаций ESC-2019</article-title><trans-title-group xml:lang="en"><trans-title>Chronic coronary syndromes: a review of the recommendations of the ESC-2019</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рудой</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Rudoy</surname><given-names>A. S.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>УО «Белорусский государственный медицинский университет»</institution></aff><aff xml:lang="en"><institution>Belarusian State Medical University</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>11</day><month>11</month><year>2025</year></pub-date><volume>3</volume><issue>2</issue><elocation-id>636–652</elocation-id><permissions><copyright-statement>Copyright &amp;#x00A9; Рудой А.С., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Рудой А.С.</copyright-holder><copyright-holder xml:lang="en">Rudoy A.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://emcardio.bsmu.by/jour/article/view/219">https://emcardio.bsmu.by/jour/article/view/219</self-uri><abstract><p>В обзоре кратко изложены ключевые положения и основные доказательства обновленных современных рекомендаций Европейского общества кардиологов 2019 года, повлиявшие на принципы ведения и лечения пациентов с хроническими коронарными синдромами. Новая концепция о признании важности многофакторных причин стенокардии и ишемии миокарда представляет собой важную эволюцию в понимании патогенеза и терапии ишемической (коронарной) болезни сердца.</p></abstract><trans-abstract xml:lang="en"><p>The review summarizes the key points and main evidence of the updated modern recommendations of the European Society of Cardiology in 2019, which influenced the principles of management and treatment of patients with chronic coronary syndromes. The new concept and recognition of the importance of the multifactorial causes of angina pectoris and myocardial ischemia represents an important evolution in understanding the pathogenesis and treatment of coronary artery disease.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>рекомендации</kwd><kwd>хронические коронарные синдромы</kwd><kwd>стенокардия</kwd><kwd>ишемия миокарда</kwd><kwd>стабильная ишемическая болезнь сердца</kwd><kwd>факторы риска</kwd><kwd>антиишемические лекарственные средства</kwd><kwd>антиагреганты</kwd><kwd>оральные антикоагулянты</kwd><kwd>реваскуляризация миокарда</kwd></kwd-group><kwd-group xml:lang="en"><kwd>guidelines</kwd><kwd>chronic coronary syndromes</kwd><kwd>angina pectoris</kwd><kwd>myocardial ischaemia</kwd><kwd>stable coronary artery disease</kwd><kwd>risk factors</kwd><kwd>anti-ischaemic drugs</kwd><kwd>antiplatelet agents</kwd><kwd>oral anticoagulants</kwd><kwd>coronary revascularization</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Knuuti, J., Wijns, W., Saraste, A., Capodanno, D., Barbato, E., Funck-Brentano, C., Prescott E., Storey R.F., Deaton C., Cuisset T., Agewall S., Dickstein K., Edvardsen T., Escaned J., Gersh B.J., Svitil P., Gilard M., Hasdai D., Hatala R., Mahfoud F., Masip J., Muneretto C., Valgimigli M., Achenbach S., Bax J.J. 2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes Eur Heart J, 2019, vol. 31, pii: ehz425. doi: 10.1093/eurheartj/ehz425.</mixed-citation><mixed-citation xml:lang="en">Knuuti, J., Wijns, W., Saraste, A., Capodanno, D., Barbato, E., Funck-Brentano, C., Prescott E., Storey R.F., Deaton C., Cuisset T., Agewall S., Dickstein K., Edvardsen T., Escaned J., Gersh B.J., Svitil P., Gilard M., Hasdai D., Hatala R., Mahfoud F., Masip J., Muneretto C., Valgimigli M., Achenbach S., Bax J.J. 2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes Eur Heart J, 2019, vol. 31, pii: ehz425. doi: 10.1093/eurheartj/ehz425.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Juarez-Orozco L.E., Saraste A., Capodanno D., Prescott E., Ballo H., Bax J.J., Wijns W., Knuuti J. Impact of a decreasing pre-test probability on the performance of diagnostic tests for coronary artery disease. Eur Heart J Cardiovasc Imaging, 2019, vol. 20, no. 11, pp. 1198–1207. doi: 10.1093/ehjci/jez054.</mixed-citation><mixed-citation xml:lang="en">Juarez-Orozco L.E., Saraste A., Capodanno D., Prescott E., Ballo H., Bax J.J., Wijns W., Knuuti J. Impact of a decreasing pre-test probability on the performance of diagnostic tests for coronary artery disease. Eur Heart J Cardiovasc Imaging, 2019, vol. 20, no. 11, pp. 1198–1207. doi: 10.1093/ehjci/jez054.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Reeh J., Therming C.B., Heitmann M., Hojberg S., Sorum C., Bech J., Husum D., Dominguez H., Sehestedt T., Hermann T., Hansen K.W., Simonsen L., Galatius S., Prescott E. Prediction of obstructive coronary artery disease and prognosis in patients with suspected stable angina. Eur Heart J, 2018, vol. 40, no. 18, pp. 1426–1435. doi: 10.1093/eurheartj/ehy806.</mixed-citation><mixed-citation xml:lang="en">Reeh J., Therming C.B., Heitmann M., Hojberg S., Sorum C., Bech J., Husum D., Dominguez H., Sehestedt T., Hermann T., Hansen K.W., Simonsen L., Galatius S., Prescott E. Prediction of obstructive coronary artery disease and prognosis in patients with suspected stable angina. Eur Heart J, 2018, vol. 40, no. 18, pp. 1426–1435. doi: 10.1093/eurheartj/ehy806.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Foldyna B., Udelson J.E., Karady J., Banerji D., Lu M.T., Mayrhofer T., Bittner D.O., Meyersohn N.M., Emami H., Genders T.S.S., Fordyce C.B., Ferencik M., Douglas P.S., Hoffmann U. Pretest probability for patients with suspected obstructive coronary artery disease: re-evaluating Diamond-Forrester for the contemporary era and clinical implications: insights from the PROMISE trial. Eur Heart J Cardiovasc Imaging, 2019, vol. 20, no. 5, pp. 574-581. doi: 10.1093/ehjci/jey182.</mixed-citation><mixed-citation xml:lang="en">Foldyna B., Udelson J.E., Karady J., Banerji D., Lu M.T., Mayrhofer T., Bittner D.O., Meyersohn N.M., Emami H., Genders T.S.S., Fordyce C.B., Ferencik M., Douglas P.S., Hoffmann U. Pretest probability for patients with suspected obstructive coronary artery disease: re-evaluating Diamond-Forrester for the contemporary era and clinical implications: insights from the PROMISE trial. Eur Heart J Cardiovasc Imaging, 2019, vol. 20, no. 5, pp. 574-581. doi: 10.1093/ehjci/jey182.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Reeh J., Therming C.B., Heitmann M., Hojberg S., Sorum C., Bech J., Husum D., Dominguez H., Sehestedt T., Hermann T., Hansen K.W., Simonsen L., Galatius S., Prescott E. Prediction of obstructive coronary artery disease and prognosis in patients with suspected stable angina. Eur Heart J, 2018, vol. 40, no. 18, pp. 1426–1435. doi: 10.1093/eurheartj/ehy806.</mixed-citation><mixed-citation xml:lang="en">Reeh J., Therming C.B., Heitmann M., Hojberg S., Sorum C., Bech J., Husum D., Dominguez H., Sehestedt T., Hermann T., Hansen K.W., Simonsen L., Galatius S., Prescott E. Prediction of obstructive coronary artery disease and prognosis in patients with suspected stable angina. Eur Heart J, 2018, vol. 40, no. 18, pp. 1426–1435. doi: 10.1093/eurheartj/ehy806.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Lindholm D., Lindbäck J., Armstrong P.W., Budaj A., Cannon C.P., Granger C.B., Hagström E., Held C., Koenig W., Östlund O., Stewart R.A.H., Soffer J., White H.D., de Winter R.J., Steg P.G., Siegbahn A., Kleber M.E., Dressel A., Grammer T.B., März W., Wallentin L. Biomarker-Based Risk Model to Predict Cardiovascular Mortality in Patients With Stable Coronary Disease. J Am Coll Cardiol, 2017, vol. 70, no. 7, pp. 813–826. doi: 10.1016/j.jacc.2017.06.030.</mixed-citation><mixed-citation xml:lang="en">Lindholm D., Lindbäck J., Armstrong P.W., Budaj A., Cannon C.P., Granger C.B., Hagström E., Held C., Koenig W., Östlund O., Stewart R.A.H., Soffer J., White H.D., de Winter R.J., Steg P.G., Siegbahn A., Kleber M.E., Dressel A., Grammer T.B., März W., Wallentin L. Biomarker-Based Risk Model to Predict Cardiovascular Mortality in Patients With Stable Coronary Disease. J Am Coll Cardiol, 2017, vol. 70, no. 7, pp. 813–826. doi: 10.1016/j.jacc.2017.06.030.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Valgimigli M., Bueno H., Byrne R.A., Collet J.P., Costa F., Jeppsson A., J ni P., Kastrati A., Kolh P., Mauri L., Montalescot G., Neumann F.J., Petricevic M., Roffi M., Steg P.G., Windecker S., Zamorano J.L. Special article 2017 ESC focused update on dual antiplatelet therapy in coronary artery disease developed in collaboration with EACTS. Rev Esp Cardiol (Engl Ed), 2018, vol. 71, no. 1, pp. 42. doi: 10.1016/j.rec.2017.11.020.</mixed-citation><mixed-citation xml:lang="en">Valgimigli M., Bueno H., Byrne R.A., Collet J.P., Costa F., Jeppsson A., J ni P., Kastrati A., Kolh P., Mauri L., Montalescot G., Neumann F.J., Petricevic M., Roffi M., Steg P.G., Windecker S., Zamorano J.L. Special article 2017 ESC focused update on dual antiplatelet therapy in coronary artery disease developed in collaboration with EACTS. Rev Esp Cardiol (Engl Ed), 2018, vol. 71, no. 1, pp. 42. doi: 10.1016/j.rec.2017.11.020.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Steffel J., Verhamme P., Potpara T.S., Albaladejo P., Antz M., Desteghe L., Haeusler K.G., Oldgren J., Reinecke H., Roldan-Schilling V., Rowell N., Sinnaeve P., Collins R., Camm A.J., Heidbüchel H. The 2018 European Heart Rhythm Association Practical Guide on the use of vitamin К antagonist oral anticoagulants in patients with atrial fibrillation. Eur Heart J, 2018, vol. 39, no. 16, pp. 1330–1393. doi: 10.1093/eurheartj/ehy136.</mixed-citation><mixed-citation xml:lang="en">Steffel J., Verhamme P., Potpara T.S., Albaladejo P., Antz M., Desteghe L., Haeusler K.G., Oldgren J., Reinecke H., Roldan-Schilling V., Rowell N., Sinnaeve P., Collins R., Camm A.J., Heidbüchel H. The 2018 European Heart Rhythm Association Practical Guide on the use of vitamin К antagonist oral anticoagulants in patients with atrial fibrillation. Eur Heart J, 2018, vol. 39, no. 16, pp. 1330–1393. doi: 10.1093/eurheartj/ehy136.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Xaplanteris P., Fournier S., Pijls N.H.J., Fearon W.F., Barbato E., Tonino P.A.L., Engstrom T., Kaab S., Dambrink J.H., Rioufol G., Toth G.G., Piroth Z., Witt N., Frobert O., Kala P., Linke A., Jagic N., Mates M., Mavromatis K., Samady H., Irimpen A., Oldroyd K., Campo G., Rothenbuhler M., Juni P., de Bruyne B. Five-year outcomes with PCI guided by fractional flow reserve. N Engl J Med, 2018, vol. 379, no. 3, pp. 250–259. doi: 10.1056/NEJMoa1803538.</mixed-citation><mixed-citation xml:lang="en">Xaplanteris P., Fournier S., Pijls N.H.J., Fearon W.F., Barbato E., Tonino P.A.L., Engstrom T., Kaab S., Dambrink J.H., Rioufol G., Toth G.G., Piroth Z., Witt N., Frobert O., Kala P., Linke A., Jagic N., Mates M., Mavromatis K., Samady H., Irimpen A., Oldroyd K., Campo G., Rothenbuhler M., Juni P., de Bruyne B. Five-year outcomes with PCI guided by fractional flow reserve. N Engl J Med, 2018, vol. 379, no. 3, pp. 250–259. doi: 10.1056/NEJMoa1803538.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Al-Lamee R., Thompson D., Dehbi H.M., Sen S., Tang K., Davies J., Keeble T., Mielewczik M., Kaprielian R., Malik I.S., Nijjer S.S., Petraco R., Cook C., Ahmad Y., Howard J., Baker C., Sharp A., Gerber R., Talwar S., Assomull R., Mayet J., Wensel R., Collier D., Shun-Shin M., Thom S.A., Davies J.E., Francis D.P. Percutaneous coronary intervention in stable angina (ORBITA): a doubleblind, randomised controlled trial. Lancet, 2018, vol. 391, no. 10115, pp. 31–40. doi: 10.1016/S0140-6736(17)32714-9.</mixed-citation><mixed-citation xml:lang="en">Al-Lamee R., Thompson D., Dehbi H.M., Sen S., Tang K., Davies J., Keeble T., Mielewczik M., Kaprielian R., Malik I.S., Nijjer S.S., Petraco R., Cook C., Ahmad Y., Howard J., Baker C., Sharp A., Gerber R., Talwar S., Assomull R., Mayet J., Wensel R., Collier D., Shun-Shin M., Thom S.A., Davies J.E., Francis D.P. Percutaneous coronary intervention in stable angina (ORBITA): a doubleblind, randomised controlled trial. Lancet, 2018, vol. 391, no. 10115, pp. 31–40. doi: 10.1016/S0140-6736(17)32714-9.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Windecker S., Stortecky S., Stefanini G.G., da Costa B.R., Rutjes A.W., Di Nisio M., Silletta M.G., Maione A., Alfonso F., Clemmensen P.M., Collet J.P., Cremer J., Falk V., Filippatos G., Hamm C., Head S., Kappetein A.P., Kastrati A., Knuuti J., Landmesser U., Laufer G., Neumann F.J., Richter D., Schauerte P., Sousa Uva M., Taggart D.P., Torracca L., Valgimigli M., Wijns W., Witkowski A., Kolh P., Juni P. Revascularisation versus medical treatment in patients with stable coronary artery disease: network meta-analysis. BMJ, 2014, vol. 23, no. 348, g3859. doi: 10.1093/eurheartj/ehw036.</mixed-citation><mixed-citation xml:lang="en">Windecker S., Stortecky S., Stefanini G.G., da Costa B.R., Rutjes A.W., Di Nisio M., Silletta M.G., Maione A., Alfonso F., Clemmensen P.M., Collet J.P., Cremer J., Falk V., Filippatos G., Hamm C., Head S., Kappetein A.P., Kastrati A., Knuuti J., Landmesser U., Laufer G., Neumann F.J., Richter D., Schauerte P., Sousa Uva M., Taggart D.P., Torracca L., Valgimigli M., Wijns W., Witkowski A., Kolh P., Juni P. Revascularisation versus medical treatment in patients with stable coronary artery disease: network meta-analysis. BMJ, 2014, vol. 23, no. 348, g3859. doi: 10.1093/eurheartj/ehw036.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Zimmermann F.M., Omerovic E., Fournier S., Kelbaek H., Johnson N.P., Rothenbuhler M., Xaplanteris P., Abdel-Wahab M., Barbato E., Hofsten D.E., Tonino P.A.L., Boxmade Klerk B.M., Fearon W.F., Kober L., Smits P.C., De Bruyne B., Pijls N.H.J., Juni P., Engstrom T. Fractional flow reserve-guided percutaneous coronary intervention vs. medical therapy for patients with stable coronary lesions: meta-analysis of individual patient data. Eur Heart J, 2019, vol. 40, no. 2, pp. 180–186. doi: 10.1093/eurheartj/ehy812.</mixed-citation><mixed-citation xml:lang="en">Zimmermann F.M., Omerovic E., Fournier S., Kelbaek H., Johnson N.P., Rothenbuhler M., Xaplanteris P., Abdel-Wahab M., Barbato E., Hofsten D.E., Tonino P.A.L., Boxmade Klerk B.M., Fearon W.F., Kober L., Smits P.C., De Bruyne B., Pijls N.H.J., Juni P., Engstrom T. Fractional flow reserve-guided percutaneous coronary intervention vs. medical therapy for patients with stable coronary lesions: meta-analysis of individual patient data. Eur Heart J, 2019, vol. 40, no. 2, pp. 180–186. doi: 10.1093/eurheartj/ehy812.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Knuuti J., Ballo H., Juarez-Orozco L.E., Saraste A., Kolh P., Rutjes A.W.S., Juni P., Windecker S., Bax J.J., Wijns W. The performance of non-invasive tests to rule-in and rule-out significant coronary artery stenosis in patients with stable angina: a meta-analysis focused on post-test disease probability. Eur Heart J, 2018, vol. 39, no. 35, pp. 3322–3330. doi: 10.1093/eurheartj/ehy267.</mixed-citation><mixed-citation xml:lang="en">Knuuti J., Ballo H., Juarez-Orozco L.E., Saraste A., Kolh P., Rutjes A.W.S., Juni P., Windecker S., Bax J.J., Wijns W. The performance of non-invasive tests to rule-in and rule-out significant coronary artery stenosis in patients with stable angina: a meta-analysis focused on post-test disease probability. Eur Heart J, 2018, vol. 39, no. 35, pp. 3322–3330. doi: 10.1093/eurheartj/ehy267.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Neumann, Franz-Josef, et al. 2018 ESC/EACTS guidelines on myocardial revascularization. Eur Heart J, 2018, vol. 40, no. 2, pp. 87–165. doi: 10.1093/eurheartj/ehu278.</mixed-citation><mixed-citation xml:lang="en">Neumann, Franz-Josef, et al. 2018 ESC/EACTS guidelines on myocardial revascularization. Eur Heart J, 2018, vol. 40, no. 2, pp. 87–165. doi: 10.1093/eurheartj/ehu278.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Giugliano R.P., Cannon C.P., Blazing M.A., Nicolau J.C., Corbalan R., Spinar J., Park J.G., White J.A., Bohula E.A., Braunwald E. IMPROVE-IT (Improved Reduc tion of Outcomes: Vytorin Efficacy International Trial) Investigators. Benefit of adding ezetimibe to statin therapy on cardiovascular outcomes and safety in patients with versus without diabetes mellitus: results from IMPROVE-IT (Improved Reduction of Outcomes: Vytorin Efficacy International Trial). Circulation, 2018, vol. 137, no. 15, pp. 1571–1582. doi: 10.1161/CIRCULATIONAHA.117.030950.</mixed-citation><mixed-citation xml:lang="en">Giugliano R.P., Cannon C.P., Blazing M.A., Nicolau J.C., Corbalan R., Spinar J., Park J.G., White J.A., Bohula E.A., Braunwald E. IMPROVE-IT (Improved Reduc tion of Outcomes: Vytorin Efficacy International Trial) Investigators. Benefit of adding ezetimibe to statin therapy on cardiovascular outcomes and safety in patients with versus without diabetes mellitus: results from IMPROVE-IT (Improved Reduction of Outcomes: Vytorin Efficacy International Trial). Circulation, 2018, vol. 137, no. 15, pp. 1571–1582. doi: 10.1161/CIRCULATIONAHA.117.030950.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Rosenson R.S., Baker S., Banach M., Borow K.M., Braun L.T., Bruckert E., Brunham L.R., Catapano A.L., Elam M.B., Mancini G.B.J., Moriarty P.M., Morris P.B., Muntner P., Ray K.K., Stroes E.S., Taylor B.A., Taylor V.H., Watts G.F., Thompson P.D. Optimizing cholesterol treatment in patients with muscle complaints. J Am Coll Cardiol, 2017, vol. 70, no. 10, pp. 1290–1301. doi: 10.1016/j.jacc.2017.07.752.</mixed-citation><mixed-citation xml:lang="en">Rosenson R.S., Baker S., Banach M., Borow K.M., Braun L.T., Bruckert E., Brunham L.R., Catapano A.L., Elam M.B., Mancini G.B.J., Moriarty P.M., Morris P.B., Muntner P., Ray K.K., Stroes E.S., Taylor B.A., Taylor V.H., Watts G.F., Thompson P.D. Optimizing cholesterol treatment in patients with muscle complaints. J Am Coll Cardiol, 2017, vol. 70, no. 10, pp. 1290–1301. doi: 10.1016/j.jacc.2017.07.752.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Mach F., Baigent C., Catapano A.L., Koskinas K.C., Casula M., Badimon L., Chapman M.J., De Backer G.G., Delgado V., Ference B.A., Graham I.M., Halliday A., Landmesser U., Mihaylova B., Pedersen T.R., Riccardi G., Richter D.J., Sabatine M.S., Taskinen M.R., Tokgozoglu L., Wiklund O. 2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk. Eur Heart J, 2019, vol. 31, pii: ehz455. doi: doi: 10.1093/eurheartj/ehz455.</mixed-citation><mixed-citation xml:lang="en">Mach F., Baigent C., Catapano A.L., Koskinas K.C., Casula M., Badimon L., Chapman M.J., De Backer G.G., Delgado V., Ference B.A., Graham I.M., Halliday A., Landmesser U., Mihaylova B., Pedersen T.R., Riccardi G., Richter D.J., Sabatine M.S., Taskinen M.R., Tokgozoglu L., Wiklund O. 2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk. Eur Heart J, 2019, vol. 31, pii: ehz455. doi: doi: 10.1093/eurheartj/ehz455.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Lloyd-Jones D.M., Morris P.B., Ballantyne C.M., Birtcher K.K., Daly D.D.Jr, De Palma S.M., Minissian M.B., Orringer C.E., Smith S.C.Jr. 2017 focused update of the 2016 ACC expert consensus decision pathway on the role of non-statin therapies for LDL-cholesterol lowering in the management of atherosclerotic cardiovascular disease risk: a report of the American College of Cardiology Task Force on Expert Consensus Decision Pathways. J Am Coll Cardiol, 2017, vol. 70, pp. 1785–1822. doi: 10.1016/j.jacc.2016.03.519</mixed-citation><mixed-citation xml:lang="en">Lloyd-Jones D.M., Morris P.B., Ballantyne C.M., Birtcher K.K., Daly D.D.Jr, De Palma S.M., Minissian M.B., Orringer C.E., Smith S.C.Jr. 2017 focused update of the 2016 ACC expert consensus decision pathway on the role of non-statin therapies for LDL-cholesterol lowering in the management of atherosclerotic cardiovascular disease risk: a report of the American College of Cardiology Task Force on Expert Consensus Decision Pathways. J Am Coll Cardiol, 2017, vol. 70, pp. 1785–1822. doi: 10.1016/j.jacc.2016.03.519</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Cosentino, F., Grant, P. J., Aboyans, V., Bailey, C. J., Ceriello, A., Delgado, V., &amp; Huikuri, H. V. 2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASDThe Task Force for diabetes, pre-diabetes, and cardiovascular diseases of the European Society of Cardiology (ESC) and the European Association for the Study of Diabetes (EASD). Eur Heart J, 2019, vol. 31, pii: ehz486. doi: 10.1093/eurheartj/ehz486.</mixed-citation><mixed-citation xml:lang="en">Cosentino, F., Grant, P. J., Aboyans, V., Bailey, C. J., Ceriello, A., Delgado, V., &amp; Huikuri, H. V. 2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASDThe Task Force for diabetes, pre-diabetes, and cardiovascular diseases of the European Society of Cardiology (ESC) and the European Association for the Study of Diabetes (EASD). Eur Heart J, 2019, vol. 31, pii: ehz486. doi: 10.1093/eurheartj/ehz486.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Piepoli M.F., Hoes A.W., Agewall S., Albus C., Brotons C., Catapano A.L., Cooney M.T., Corra U., Cosyns B., Deaton C., Graham I., Hall M.S., Hobbs F.D.R., Lochen M.L., Lollgen H., Marques-Vidal P., Perk J., Prescott E., Redon J., Richter D.J., Sattar N., Smulders Y., Tiberi M., van der Worp H.B., van Dis I., Verschuren W.M.M., Binno S. ESC Scientific Document Group. 2016 European Guidelines on cardiovascular disease prevention in clinical practice: The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts) Develope d with the spe cial contribution of the European A ssociation for Cardiovascular Prevention &amp; Rehabilitation (EACPR). Eur Heart J, 2016, vol. 37, no. 29, pp. 2315–2381. doi: 10.1093/eurheartj/ehw106</mixed-citation><mixed-citation xml:lang="en">Piepoli M.F., Hoes A.W., Agewall S., Albus C., Brotons C., Catapano A.L., Cooney M.T., Corra U., Cosyns B., Deaton C., Graham I., Hall M.S., Hobbs F.D.R., Lochen M.L., Lollgen H., Marques-Vidal P., Perk J., Prescott E., Redon J., Richter D.J., Sattar N., Smulders Y., Tiberi M., van der Worp H.B., van Dis I., Verschuren W.M.M., Binno S. ESC Scientific Document Group. 2016 European Guidelines on cardiovascular disease prevention in clinical practice: The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts) Develope d with the spe cial contribution of the European A ssociation for Cardiovascular Prevention &amp; Rehabilitation (EACPR). Eur Heart J, 2016, vol. 37, no. 29, pp. 2315–2381. doi: 10.1093/eurheartj/ehw106</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Bangalore S., Fakheri R., Wandel S., Toklu B., Wandel J., Messerli F.H. Renin angiotensin system inhibitors for patients with stable coronary artery disease without heart failure: systematic review and meta-analysis of randomized trials. BMJ, 2017, vol. 19, pp. 356. doi: 10.1136/bmj.j4.</mixed-citation><mixed-citation xml:lang="en">Bangalore S., Fakheri R., Wandel S., Toklu B., Wandel J., Messerli F.H. Renin angiotensin system inhibitors for patients with stable coronary artery disease without heart failure: systematic review and meta-analysis of randomized trials. BMJ, 2017, vol. 19, pp. 356. doi: 10.1136/bmj.j4.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Fox KM, Mulcahy D, Findlay I, Ford I, Dargie HJ. The Total Ischaemic BurdenEuropean Trial (TIBET). Effects of atenolol, nifedipine SR and their combination on the exercise test and the total ischaemic burden in 608 patients with stable angina. The TIBET Study Group. Eur Heart J, 1996, vol. 17, no. 1, pp 96–103. doi: 10.1093/oxfordjournals. eurheartj.a014699.</mixed-citation><mixed-citation xml:lang="en">Fox KM, Mulcahy D, Findlay I, Ford I, Dargie HJ. The Total Ischaemic BurdenEuropean Trial (TIBET). Effects of atenolol, nifedipine SR and their combination on the exercise test and the total ischaemic burden in 608 patients with stable angina. The TIBET Study Group. Eur Heart J, 1996, vol. 17, no. 1, pp 96–103. doi: 10.1093/oxfordjournals. eurheartj.a014699.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Shu de F., Dong B.R., Lin X.F., Wu T.X., Liu G.J. Long-term beta blockers for stable angina: systematic review and meta-analysis. Eur J Prev Cardiol, 2012, vol. 19, no. 3, pp. 33–341. doi: 10.1177/1741826711409325.</mixed-citation><mixed-citation xml:lang="en">Shu de F., Dong B.R., Lin X.F., Wu T.X., Liu G.J. Long-term beta blockers for stable angina: systematic review and meta-analysis. Eur J Prev Cardiol, 2012, vol. 19, no. 3, pp. 33–341. doi: 10.1177/1741826711409325.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Wallace W.A., Wellington K.L., Chess M.A., Liang C.S. Comparison of nifedipine gastrointestinal therapeutic system and atenolol on antianginal efficacies and exercise hemodynamic responses in stable angina pectoris. Am J Cardiol, 1994, vol. 73, pp. 23–28. doi: 10.1016/0002-9149(94)90721-8.</mixed-citation><mixed-citation xml:lang="en">Wallace W.A., Wellington K.L., Chess M.A., Liang C.S. Comparison of nifedipine gastrointestinal therapeutic system and atenolol on antianginal efficacies and exercise hemodynamic responses in stable angina pectoris. Am J Cardiol, 1994, vol. 73, pp. 23–28. doi: 10.1016/0002-9149(94)90721-8.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Kawanishi D.T., Reid C.L., Morrison E.C., Rahimtoola S.H. Response of angina and ischemia to long-term treatment in patients with chronic stable angina: a double-blind randomized individualized dosing trial of nifedipine, propranolol and their combination. J Am Coll Cardiol, 1992, vol. 19, pp. 409–417. doi: 10.1016/0735-1097(92)90499-D.</mixed-citation><mixed-citation xml:lang="en">Kawanishi D.T., Reid C.L., Morrison E.C., Rahimtoola S.H. Response of angina and ischemia to long-term treatment in patients with chronic stable angina: a double-blind randomized individualized dosing trial of nifedipine, propranolol and their combination. J Am Coll Cardiol, 1992, vol. 19, pp. 409–417. doi: 10.1016/0735-1097(92)90499-D.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Hwang D., Lee J.M., Kim H.K., Choi K.H., Rhee T.M., Park J., Park T.K., Yang J.H., Song Y.B., Choi J.H., Hahn J.Y., Choi S.H., Koo B.K., Kim Y.J., Chae S.C., Cho M.C., Kim C.J., Gwon H.C., Jeong M.H., Kim H.S. Prognostic impact of betablocker dose after acute myocardial infarc tion. Circ J, 2019, vol. 83, pp. 410 –417. doi: 10.1016/j. jacc.2017.12.028.</mixed-citation><mixed-citation xml:lang="en">Hwang D., Lee J.M., Kim H.K., Choi K.H., Rhee T.M., Park J., Park T.K., Yang J.H., Song Y.B., Choi J.H., Hahn J.Y., Choi S.H., Koo B.K., Kim Y.J., Chae S.C., Cho M.C., Kim C.J., Gwon H.C., Jeong M.H., Kim H.S. Prognostic impact of betablocker dose after acute myocardial infarc tion. Circ J, 2019, vol. 83, pp. 410 –417. doi: 10.1016/j. jacc.2017.12.028.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Bangalore S., Steg G., Deedwania P., Crowley K., Eagle K.A., Goto S., Ohman E.M., Cannon C.P., Smith S.C., Zeymer U., Hoffman E.B., Messerli F.H., Bhatt D.L. b-Blocker use and clinical outcomes in stable outpatients with and without coronary artery disease. JAMA, 2012, vol. 308, no. 13, pp. 1340–1349. doi: 10.1001/jama.2012.12559.</mixed-citation><mixed-citation xml:lang="en">Bangalore S., Steg G., Deedwania P., Crowley K., Eagle K.A., Goto S., Ohman E.M., Cannon C.P., Smith S.C., Zeymer U., Hoffman E.B., Messerli F.H., Bhatt D.L. b-Blocker use and clinical outcomes in stable outpatients with and without coronary artery disease. JAMA, 2012, vol. 308, no. 13, pp. 1340–1349. doi: 10.1001/jama.2012.12559.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Motivala A.A., Parikh V., Roe M., Dai D., Abbott J.D., Prasad A., Mukherjee D. Predictors, trends, and outcomes (among older patients ≥ 65 years of age) associated with beta-blocker use in patients with stable angina undergoing elective percutaneous coronary intervention: insights From the NCDR registry. JACC Cardiovasc Interv, 2016, vol. 9, no. 16, pp. 1639–1648. doi: 10.1016/j.jcin.2016.05.048.</mixed-citation><mixed-citation xml:lang="en">Motivala A.A., Parikh V., Roe M., Dai D., Abbott J.D., Prasad A., Mukherjee D. Predictors, trends, and outcomes (among older patients ≥ 65 years of age) associated with beta-blocker use in patients with stable angina undergoing elective percutaneous coronary intervention: insights From the NCDR registry. JACC Cardiovasc Interv, 2016, vol. 9, no. 16, pp. 1639–1648. doi: 10.1016/j.jcin.2016.05.048.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Dahl Aarvik M., Sandven I., Dondo T.B., Gale C.P., Ruddox V., Munkhaugen J., Atar D., Otterstad J.E.. Effect of oral beta-blocker treatment on mortality in contemporary post-myocardial infarction patients: a systematic review and meta-analysis. Eur Heart J Cardiovasc Pharmacother, 2019, vol. 5, no. 1, pp. 12–20. doi: 10.1093/ehjcvp/pvy034.</mixed-citation><mixed-citation xml:lang="en">Dahl Aarvik M., Sandven I., Dondo T.B., Gale C.P., Ruddox V., Munkhaugen J., Atar D., Otterstad J.E.. Effect of oral beta-blocker treatment on mortality in contemporary post-myocardial infarction patients: a systematic review and meta-analysis. Eur Heart J Cardiovasc Pharmacother, 2019, vol. 5, no. 1, pp. 12–20. doi: 10.1093/ehjcvp/pvy034.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Puymirat E., Riant E., Aissaoui N., Soria A., Ducrocq G., Coste P., Cottin Y., Aupetit J.F., Bonnefoy E., Blanchard D., Cattan S., Steg G., Schiele F., Ferrie`res J., Juillie`re Y., Simon T., Danchin N. B blockers and mortality after myocardial infarction in patients without heart failure: multicentre prospective cohort study. BMJ, 2016, vol. 354, pp. i4801. doi: 10.1136/bmj.i4801.</mixed-citation><mixed-citation xml:lang="en">Puymirat E., Riant E., Aissaoui N., Soria A., Ducrocq G., Coste P., Cottin Y., Aupetit J.F., Bonnefoy E., Blanchard D., Cattan S., Steg G., Schiele F., Ferrie`res J., Juillie`re Y., Simon T., Danchin N. B blockers and mortality after myocardial infarction in patients without heart failure: multicentre prospective cohort study. BMJ, 2016, vol. 354, pp. i4801. doi: 10.1136/bmj.i4801.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Sorbets E., Steg P.G., Young R., Danchin N., Greenlaw N., Ford I., Tendera M., Ferrari R., Merkely B., Parkhomenko A., Reid C., Tardif J.C., Fox K.M. b-blockers, calcium antagonists, and mortality in stable coronary artery disease: an international cohort study. Eur Heart J, 2018, vol. 40, pp. 1399–1407. doi: 10.1093/eurheartj/ehy811.</mixed-citation><mixed-citation xml:lang="en">Sorbets E., Steg P.G., Young R., Danchin N., Greenlaw N., Ford I., Tendera M., Ferrari R., Merkely B., Parkhomenko A., Reid C., Tardif J.C., Fox K.M. b-blockers, calcium antagonists, and mortality in stable coronary artery disease: an international cohort study. Eur Heart J, 2018, vol. 40, pp. 1399–1407. doi: 10.1093/eurheartj/ehy811.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang H., Yuan X., Zhang H., Chen S., Zhao Y., Hua K., Rao C., Wang W., Sun H., Hu S., Zheng Z. Efficacy of long-term beta-blocker therapy for secondary prevention of long-term outcomes after coronary artery bypass grafting surgery. Circulation, 2015, vol. 131, pp. 2194–2201. doi: 10.1161/CIRCULATIONAHA.114.014209.</mixed-citation><mixed-citation xml:lang="en">Zhang H., Yuan X., Zhang H., Chen S., Zhao Y., Hua K., Rao C., Wang W., Sun H., Hu S., Zheng Z. Efficacy of long-term beta-blocker therapy for secondary prevention of long-term outcomes after coronary artery bypass grafting surgery. Circulation, 2015, vol. 131, pp. 2194–2201. doi: 10.1161/CIRCULATIONAHA.114.014209.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Rousan T.A., Mathew S.T., Thadani U. Drug therapy for stable angina pectoris. Drugs, 2017, vol. 77, pp. 265-284. doi: 10.1007/s40265-017-0691-7.</mixed-citation><mixed-citation xml:lang="en">Rousan T.A., Mathew S.T., Thadani U. Drug therapy for stable angina pectoris. Drugs, 2017, vol. 77, pp. 265-284. doi: 10.1007/s40265-017-0691-7.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Heidenreich P.A., McDonald K.M., Hastie T., Fadel B., Hagan V., Lee B.K., Hlatky M.A. Meta-analysis of trials comparing beta-blockers, calcium antagonists and nitrates for stable angina. JAMA, 1999, vol. 281, pp. 1927–1936. doi: 10.1097/00132586-200004000-00039.</mixed-citation><mixed-citation xml:lang="en">Heidenreich P.A., McDonald K.M., Hastie T., Fadel B., Hagan V., Lee B.K., Hlatky M.A. Meta-analysis of trials comparing beta-blockers, calcium antagonists and nitrates for stable angina. JAMA, 1999, vol. 281, pp. 1927–1936. doi: 10.1097/00132586-200004000-00039.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Ruzyllo W., Tendera M., Ford I., Fox K.M. Antianginal ef ficacy and safety of ivabradine compared with amlodipine in patients with stable effort angina pectoris: a 3-month randomised, double-blind, multicentre, noninferiority trial. Drugs, 2007, vol. 67, pp. 393–405. doi: 10.2165/00003495-200767030-00005.</mixed-citation><mixed-citation xml:lang="en">Ruzyllo W., Tendera M., Ford I., Fox K.M. Antianginal ef ficacy and safety of ivabradine compared with amlodipine in patients with stable effort angina pectoris: a 3-month randomised, double-blind, multicentre, noninferiority trial. Drugs, 2007, vol. 67, pp. 393–405. doi: 10.2165/00003495-200767030-00005.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Tardif J.C., Ford I., Tendera M., Bourassa M.G, Fox K. Ef ficacy of ivabradine, a new selective I(f ) inhibitor, compared with atenolol in patients with chronic stable angina. Eur Heart J, 2005, vol. 26, pp. 2529–2536. doi: 10.1093/eurheartj/ehi586.</mixed-citation><mixed-citation xml:lang="en">Tardif J.C., Ford I., Tendera M., Bourassa M.G, Fox K. Ef ficacy of ivabradine, a new selective I(f ) inhibitor, compared with atenolol in patients with chronic stable angina. Eur Heart J, 2005, vol. 26, pp. 2529–2536. doi: 10.1093/eurheartj/ehi586.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Tardif J.C., Ponikowski P., Kahan T. Efficacy of the I(f) current inhibitor ivabradine in patients with chronic stable angina receiving beta-blocker therapy: a 4-month, randomized, placebo-controlled trial. Eur Heart J, 2009, vol. 30, pp. 540–548. doi: 10.1016/S0140-6736(02)08265-X.</mixed-citation><mixed-citation xml:lang="en">Tardif J.C., Ponikowski P., Kahan T. Efficacy of the I(f) current inhibitor ivabradine in patients with chronic stable angina receiving beta-blocker therapy: a 4-month, randomized, placebo-controlled trial. Eur Heart J, 2009, vol. 30, pp. 540–548. doi: 10.1016/S0140-6736(02)08265-X.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">IONA Study Group. Effect of nicorandil on coronary events in patients with stable angina: the Impact Of Nicorandil in Angina (IONA) randomised trial. Lancet, 2002, vol. 359, pp. 1269–1275. doi: 10.1016/S0140-6736(02)08265-X.</mixed-citation><mixed-citation xml:lang="en">IONA Study Group. Effect of nicorandil on coronary events in patients with stable angina: the Impact Of Nicorandil in Angina (IONA) randomised trial. Lancet, 2002, vol. 359, pp. 1269–1275. doi: 10.1016/S0140-6736(02)08265-X.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Morrow D.A., Scirica B.M., Karwatowska-Prokopczuk E., Murphy S.A., Budaj A., Varshavsky S., Wolff A.A., Skene A., McCabe C.H., Braunwald E. Effects of ranolazine on recurrent cardiovascular events in patients with non-ST-elevation acute coronary syndromes: the MERLIN-TIMI 36 randomized trial. JAMA, 2007, vol. 297, pp. 1775–1783. doi: 10.1001/jama.297.16.1775.</mixed-citation><mixed-citation xml:lang="en">Morrow D.A., Scirica B.M., Karwatowska-Prokopczuk E., Murphy S.A., Budaj A., Varshavsky S., Wolff A.A., Skene A., McCabe C.H., Braunwald E. Effects of ranolazine on recurrent cardiovascular events in patients with non-ST-elevation acute coronary syndromes: the MERLIN-TIMI 36 randomized trial. JAMA, 2007, vol. 297, pp. 1775–1783. doi: 10.1001/jama.297.16.1775.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Kosiborod M., Arnold S.V., Spertus J.A., McGuire D.K., Li Y., Yue P., Ben-Yehuda O., Katz A., Jones P.G., Olmsted A., Belardinelli L., Chaitman B.R. Evaluation of ranolazine in patients with type 2 diabetes mellitus and chronic stable angina: results from the TERISA randomized clinical trial (Type 2 Diabetes Evaluation of Ranolazine in Subjects With Chronic Stable Angina). J Am Coll Cardiol, 2013, vol. 61, pp.2038–2045. doi: 10.1016/j.jacc.2013.02.011.</mixed-citation><mixed-citation xml:lang="en">Kosiborod M., Arnold S.V., Spertus J.A., McGuire D.K., Li Y., Yue P., Ben-Yehuda O., Katz A., Jones P.G., Olmsted A., Belardinelli L., Chaitman B.R. Evaluation of ranolazine in patients with type 2 diabetes mellitus and chronic stable angina: results from the TERISA randomized clinical trial (Type 2 Diabetes Evaluation of Ranolazine in Subjects With Chronic Stable Angina). J Am Coll Cardiol, 2013, vol. 61, pp.2038–2045. doi: 10.1016/j.jacc.2013.02.011.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Weisz G., Genereux P., Iniguez A., Zurakowski A., Shechter M., Alexander K.P., Dressler O., Osmukhina A., James S., Ohman E.M., Ben-Yehuda O., Farzaneh-Far R., Stone G.W. Ranolazine in patients with incomplete revascularisation af ter percutaneous coronary intervention (RIVER-PCI): a multicentre, randomised, double-blind, placebo-controlled trial. Lancet, 2016, vol. 387, pp. 136–145. doi: 10.1016/S0140-6736(15)00459-6.</mixed-citation><mixed-citation xml:lang="en">Weisz G., Genereux P., Iniguez A., Zurakowski A., Shechter M., Alexander K.P., Dressler O., Osmukhina A., James S., Ohman E.M., Ben-Yehuda O., Farzaneh-Far R., Stone G.W. Ranolazine in patients with incomplete revascularisation af ter percutaneous coronary intervention (RIVER-PCI): a multicentre, randomised, double-blind, placebo-controlled trial. Lancet, 2016, vol. 387, pp. 136–145. doi: 10.1016/S0140-6736(15)00459-6.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Peng S., Zhao M., Wan J., Fang Q., Fang D., Li K. The efficacy of trimetazidine on stable angina pectoris: a meta-analysis of randomized clinical trials. Int J Cardiol, 2014, vol. 177, pp. 780–785. doi: 10.1016/j.ijcard.2014.10.149.</mixed-citation><mixed-citation xml:lang="en">Peng S., Zhao M., Wan J., Fang Q., Fang D., Li K. The efficacy of trimetazidine on stable angina pectoris: a meta-analysis of randomized clinical trials. Int J Cardiol, 2014, vol. 177, pp. 780–785. doi: 10.1016/j.ijcard.2014.10.149.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Noman A., Ang D.S., Ogston S., Lang C.C., Struthers A.D. Effect of high-dose allopurinol on exercise in patients with chronic stable angina: a randomised, placebo controlled crossover trial. Lancet, 2010, vol. 375, pp. 2161–2167. doi: 10.1016/S0140-6736(10)60391-1.</mixed-citation><mixed-citation xml:lang="en">Noman A., Ang D.S., Ogston S., Lang C.C., Struthers A.D. Effect of high-dose allopurinol on exercise in patients with chronic stable angina: a randomised, placebo controlled crossover trial. Lancet, 2010, vol. 375, pp. 2161–2167. doi: 10.1016/S0140-6736(10)60391-1.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Singh J.A., Yu S. Allopurinol reduces the risk of myocardial infarction (MI) in the elderly: a study of Medicare claims. Arthritis Res Ther, 2016, vol. 18, pp. 209. doi: 10.1186/s13075-016-1111-1.</mixed-citation><mixed-citation xml:lang="en">Singh J.A., Yu S. Allopurinol reduces the risk of myocardial infarction (MI) in the elderly: a study of Medicare claims. Arthritis Res Ther, 2016, vol. 18, pp. 209. doi: 10.1186/s13075-016-1111-1.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Ambrosio G., Mugelli A., Lopez-Sendón J., Tamargo J., Camm J. Management of stable angina: A commentary on the European Society of Cardiology guidelines. Eur J Prev Cardiol. 2016, vol. 23, no. 13, pp. 1401–1412. doi: 10.1177/2047487316648475.</mixed-citation><mixed-citation xml:lang="en">Ambrosio G., Mugelli A., Lopez-Sendón J., Tamargo J., Camm J. Management of stable angina: A commentary on the European Society of Cardiology guidelines. Eur J Prev Cardiol. 2016, vol. 23, no. 13, pp. 1401–1412. doi: 10.1177/2047487316648475.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Verma S., McMurray J.J.V., Cherney D.Z.I. The metabolodiuretic promise of sodium-dependent glucose cotransporter 2 inhibition: the search for the sweetspot in heart failure. JAMA Cardiol, 2017, vol. 2, pp. 939-940. doi: 10.1001/jamacardio.2017.1891.</mixed-citation><mixed-citation xml:lang="en">Verma S., McMurray J.J.V., Cherney D.Z.I. The metabolodiuretic promise of sodium-dependent glucose cotransporter 2 inhibition: the search for the sweetspot in heart failure. JAMA Cardiol, 2017, vol. 2, pp. 939-940. doi: 10.1001/jamacardio.2017.1891.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Catapano A.L., Graham I., De Backer G., Wiklund O., Chapman M.J., Drexel H., Hoes A.W., Jennings C.S., Landmesser U., Pedersen T.R., Reiner Z., Riccardi G., Taskinen M.R., Tokgozoglu L., Verschuren W.M.M., Vlachopoulos C., Wood D.A., Zamorano J.L., Cooney M.T. 2016 ESC/EAS Guidelines for the management of dyslipidaemias. Eur Heart J, 2016, vol. 37, pp. 2999–3058. doi: 10.1093/eurheartj/ehz455.</mixed-citation><mixed-citation xml:lang="en">Catapano A.L., Graham I., De Backer G., Wiklund O., Chapman M.J., Drexel H., Hoes A.W., Jennings C.S., Landmesser U., Pedersen T.R., Reiner Z., Riccardi G., Taskinen M.R., Tokgozoglu L., Verschuren W.M.M., Vlachopoulos C., Wood D.A., Zamorano J.L., Cooney M.T. 2016 ESC/EAS Guidelines for the management of dyslipidaemias. Eur Heart J, 2016, vol. 37, pp. 2999–3058. doi: 10.1093/eurheartj/ehz455.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
