emcardioНеотложная кардиология и кардиоваскулярные рискиEmergency Cardiology and Cardiovascular Risks journal2616-633XБелорусский государственный медицинский университетemcardio-212Research ArticleОригинальные научные публикацииOriginal Scientific ResearchФактор роста фибробластов 21 с позиции перспективного маркера метаболических нарушений и преждевременного старения при полиморбидной сердечно-сосудистой патологии у лиц молодого и среднего возрастаFibroblast growth factor 21 from the perspective of a promising marker of metabolic disorders and premature aging in polymorbid cardiovascular pathology in young and middle-aged peopleПрощайГ. А.ProshchaiG. I.ДударенкоС. В.DudarenkoS. V.ПарцернякА. С.PartcerniakA. S.ЗагарскихЕ. Ю.ZagarskikhE. Yu.ПарцернякС. А.PartcerniakS. A.ФГБУ ВО "СЗГМУ им. И.И. Мечникова" Минздрава РоссииNorth-Western State Medical University named after I. I. MechnikovФГБУ «ВЦЭРМ» МЧС РоссииARCERM, EMERCOM of RussiaФГБУ ВО «СПбАУ РАН имени Ж.И. Алферова»St Petersburg Academic University named after J.I. Alferova202010112025421002–1005Copyright © Прощай Г.А., Дударенко С.В., Парцерняк А.С., Загарских Е.Ю., Парцерняк С.А., 20252025Прощай Г.А., Дударенко С.В., Парцерняк А.С., Загарских Е.Ю., Парцерняк С.А.Proshchai G.I., Dudarenko S.V., Partcerniak A.S., Zagarskikh E.Y., Partcerniak S.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://emcardio.bsmu.by/jour/article/view/212

Цель: Оценить возможность применения фактора роста фибробластов 21 (FGF 21) в качестве маркера метаболических нарушений и преждевременного старения при полиморбидной сердечно-сосудистой патологии. Методы исследования: обследовано 199 мужчин в возрасте 35–55 лет, которые были стратифицированы на 3 контингента: контингент А – 117 пациентов с сахарным диабетом 2 типа (СД 2 типа), полиморбидной сердечно-сосудистой патологией (ПССП), ожирением, андрогенным дефицитом и тревожно-депрессивными расстройствами (ТДР; контингент Б – 55 пациентов с ПССП, ожирением и ТДР; контингент В – контрольная группа (n = 27). Обследование пациентов включало лабораторное исследование уровня FGF 21, показателей углеводного и липидного обмена, гормонального статуса, а также суточное мониторирование АД и ЭКГ. Результаты и выводы. При сравнении с контрольной группой уровень FGF 21 при наличии СД 2 типа был в 3 раза выше. Наиболее интенсивное увеличение уровня FGF 21 отмечено в группах пациентов с несколькими заболеваниями. Повышение уровня FGF 21 у лиц молодого и среднего возраста вероятно обусловлено компенсаторной реакцией на имеющиеся андрогенный дефицит, нарушения углеводного и липидного обмена. Сильные корреляционные взаимосвязи между FGF 21 и глюкозой, ХС ЛПВП, общим тестостероном, АЛТ, САД днем позволяют рассматривать FGF 21 ранним маркером сердечно-сосудистых заболеваний и преждевременного старения ПС у лиц молодого и среднего возраста.

Objective: To evaluate the possibility of using fibroblast growth factor 21 (FGF 21) as a marker of metabolic disorders and premature aging in polymorbid cardiovascular pathology. Research methods: 199 men aged 35–55 years who were stratified into 3 groups were examined: group A – 117 patients with type 2 diabetes mellitus (type 2 diabetes), polymorbid cardiovascular disease (PCVD), obesity, androgen deficiency and anxiety-depressive disorders (ADD); group B – 55 patients with PCVD, obesity and ADD; group C – control group (n = 27). The examination of patients included a laboratory study of the level of FGF 21, indicators of carbohydrate and lipid metabolism, hormonal status, as well as daily monitoring of blood pressure and ECG. Results and conclusions. When compared with the control group, the level of FGF 21 was 3 times higher in the presence of type 2 diabetes. The most intense increase in FGF 21 levels was observed in groups of patients with several diseases. An increase in the level of FGF 21 in young and middle-aged people is probably due to a compensatory reaction to the existing androgen deficiency, disorders of carbohydrate and lipid metabolism. Strong correlations between FGF 21 and glucose, HDL cholesterol, total testosterone, ALT, and SBP during the day allow FGF 21 to be considered an early marker of cardiovascular disease and premature aging (PA) in young and middle-aged people.

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The authors declare that there are no conflicts of interest present.