emcardioНеотложная кардиология и кардиоваскулярные рискиEmergency Cardiology and Cardiovascular Risks journal2616-633XБелорусский государственный медицинский университетemcardio-211Research ArticleОригинальные научные публикацииOriginal Scientific ResearchСовременные возможности дигностики и лечения системных васкулитов с поражением почек у детей: собственные данные (часть 2)Modern opportunities for diagnosis and treatment of systemic vasculitis with kidney involvement in children: researchers own data (part 2)КозыроИ. А.KazyraI. A.kozyroia@mail.ruСукалоА. В.SukaloA. V.УО «Белорусский государственный медицинский университет»Belarusian State Medical University20201011202542994–1001Copyright © Козыро И.А., Сукало А.В., 20252025Козыро И.А., Сукало А.В.Kazyra I.A., Sukalo A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://emcardio.bsmu.by/jour/article/view/211

Целью исследования явился анализ клинических, лабораторных, иммунологических, патоморфологических данных детей с системным васкулитом (СВ) с поражением почек для оценки медиаторов формирования и прогрессирования болезни, а также факторов, влияющих на прогноз. Материалы и методы. 20 детей (15 девочек, 5 мальчиков) с нефритом вследствие СВ в возрасте от 5 до 17 лет (медиана 13,5), находившихся под наблюдением в УЗ «2-я детская клиническая больница» г. Минска в период с 2012–2020 гг. Представлены особенности дебюта заболевания в детском возрасте, проведен анализ клинических, лабораторных, иммунологических (концентрация в крови маркеров активации Т- и В-лимфоцитов (RANTES и BAFF), провоспалительных (каспазы 1, IL1β и TNFα), факторов сосудистого (VEGF) и тканевого (TGF1β) роста), показателей метаболического статуса (адипонектина, лептина, обестатина, витамина Д 25 (ОН)D), инструментальных, патоморфологических изменений, а также факторов, влияющих на течение и прогноз. Статистическая обработка полученных результатов проведена с использованием программного пакета Statistica 10.0, SPSS.

The aim of the study was to analyze clinical, laboratory, immunological, morphological data of children with systemic vasculitis (SV) with kidney involvement to assess mediators of the formation and progression of the disease, as well as factors affecting prognosis. Methods. 20 children (15 girls, 5 boys) with morphologically verified nephritis due to SV (age from 5 to 17 yrs, median 13.5), were under observation at the “2nd Children’s Clinical Hospital” Minsk from 2012–2020. The features of the onset of the disease in childhood are presented, the analysis of clinical, laboratory, immunological (serum concentration of T- and B-lymphocyte activation markers (RANTES and BAFF), proinflammatory (caspase 1, IL1β and TNFα), vascular (VEGF) and tissue (TGF1β) growth factors), metabolic parameters (adiponectin, leptin, obestatin, vitamin D 25 (OH) D), instrumental, morphological changes, and factors affecting the course and outcome. Statistics was carried out using the Statistica 10.0, SPSS.

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The authors declare that there are no conflicts of interest present.