emcardioНеотложная кардиология и кардиоваскулярные рискиEmergency Cardiology and Cardiovascular Risks journal2616-633XБелорусский государственный медицинский университетemcardio-201Research ArticleОбзоры и лекцииReviews and lecturesРаспространение пульсовой волны по малым сосудам: результаты измерений и подходы к моделированиюРulse waves рropagation in small vessels: measurement results and modelling approachesКубаркоА. И.KubarkoA. I.kubarko@bsmu.byМансуровВ. А.MansurovV. A.СветличныйА. Д.SvetlichnyA. D.РагуновичЛ. Д.RagunovichL. D.УО «Белорусский государственный медицинский университет»Belarusian State Medical University202010112025421037–1044Copyright © Кубарко А.И., Мансуров В.А., Светличный А.Д., Рагунович Л.Д., 20252025Кубарко А.И., Мансуров В.А., Светличный А.Д., Рагунович Л.Д.Kubarko A.I., Mansurov V.A., Svetlichny A.D., Ragunovich L.D.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://emcardio.bsmu.by/jour/article/view/201

Целью исследования было разработать приспособления, алгоритм синхронной регистрации пульсовых колебаний и электрокардиограммы для измерения времени запаздывания пульсовой волны в ветвях различных артерий относительно зубца R на ЭКГ и провести компьютерное моделирование процесса распространения пульсовой волны для выявления зависимости скорости распространения пульсовой волны от разветвленности и других гемодинамических и морфологических параметров сосудов.

The objective of the research work was to develop devices and algorithm for synchronous recording of pulse waves and ECG for measuring the delay time of pulse waves in the branches of various arteries relative to the R wave on an ECG, and to carry out computer simulation of the pulse wave propagation process to determine the dependence of the pulse wave propagation velocity on branching and other hemodynamic and morphological parameters of blood vessels.

пульсовая волнаскорость распространения пульсовой волнымалые артериальные сосудымоделирование процесса распространения пульсовой волныpulse wavepulse wave propagation velocitysmall arterial vesselspulse wave propagation modelingReferencesShirwany N.A, Zou M-hui. Arterial stiffness: a brief review. Acta Pharmacologica Sinica, 2010, no. 31, pp. 1267-1276.Shirwany N.A, Zou M-hui. Arterial stiffness: a brief review. Acta Pharmacologica Sinica, 2010, no. 31, pp. 1267-1276.Safar M. E., Lacolley P. Disturbance of macro- and microcirculation: relations with pulse pressure and cardiac organ damage. Am J Physiol Heart Circ Physiol, 2007, vol. 293, pp. H1-H7.Safar M. E., Lacolley P. Disturbance of macro- and microcirculation: relations with pulse pressure and cardiac organ damage. Am J Physiol Heart Circ Physiol, 2007, vol. 293, pp. H1-H7.Каtz J.А. Parchoniuk Е.V. Akimov N.S. Zhestkost’ sosudistoy stenki s pozizii povrezhdeniya soedinitel’noy tkani pri serdechno-sosudistych zabolevaniyach [The stiffness of vascular wall with position of damage connective tissue in cardiovascular deseases]. Fundamental Researches, 2013, no. 5, pp. 189-195. (in Russian).Каtz J.А. Parchoniuk Е.V. Akimov N.S. Zhestkost’ sosudistoy stenki s pozizii povrezhdeniya soedinitel’noy tkani pri serdechno-sosudistych zabolevaniyach [The stiffness of vascular wall with position of damage connective tissue in cardiovascular deseases]. Fundamental Researches, 2013, no. 5, pp. 189-195. (in Russian).Feihl F., Liaudet L., Waeber B., Levy B.I. Hypertension A Disease of the Microcirculation? Hypertension, 2006, vol. 48, pp. 1012-1017.Feihl F., Liaudet L., Waeber B., Levy B.I. Hypertension A Disease of the Microcirculation? Hypertension, 2006, vol. 48, pp. 1012-1017.Heskens L.H., Kroon A.A., van Oostenbrugge R.J., Gronenschild E.H., Fuss-Lejeune M.M., Hofman P.A., Lodder J., de Leeuw P.W. Increased aortic pulse wave velocity is associated with silent cerebral small vessel disease in hypertensive patients. Hypertension, 2008, vol. 52, no. 6, pp. 1120-1126.Heskens L.H., Kroon A.A., van Oostenbrugge R.J., Gronenschild E.H., Fuss-Lejeune M.M., Hofman P.A., Lodder J., de Leeuw P.W. Increased aortic pulse wave velocity is associated with silent cerebral small vessel disease in hypertensive patients. Hypertension, 2008, vol. 52, no. 6, pp. 1120-1126.Lee Y-S. Kim K-S., Nam Ch-W., Han S-W., Hur S-H., Kim Y-N., Kim K-B., Lee J-B. Clinical implication of carotid-radial pulse wave velocity for patients with coronary artery disease. Korean Circulation J, 2006, vol. 36, no. 8, pp. 565-572.Lee Y-S. Kim K-S., Nam Ch-W., Han S-W., Hur S-H., Kim Y-N., Kim K-B., Lee J-B. Clinical implication of carotid-radial pulse wave velocity for patients with coronary artery disease. Korean Circulation J, 2006, vol. 36, no. 8, pp. 565-572.Townsend R.R., Wilkinson I.B., Schiffrin E.L., Avolio A.P., Chirinos J.A., Cockcroft J.R., Heffernan K.S., Lakatta E.G., McEniery C.M., Mitchell G.F., Najjar S.S., Nichols WW., Urbina E.M., Weber T. Recommendations for improving and standardizing vascular research on arterial stiffness: a scientific statement from the American Heart Association. Hypertension, 2015, vol. 66, no. 3, pp. 698-722.Townsend R.R., Wilkinson I.B., Schiffrin E.L., Avolio A.P., Chirinos J.A., Cockcroft J.R., Heffernan K.S., Lakatta E.G., McEniery C.M., Mitchell G.F., Najjar S.S., Nichols WW., Urbina E.M., Weber T. Recommendations for improving and standardizing vascular research on arterial stiffness: a scientific statement from the American Heart Association. Hypertension, 2015, vol. 66, no. 3, pp. 698-722.Susic D, Varagic J, Ahn J, Frohlich E.D. Crosslink breakers: a new approach to cardiovascular therapy. Curr Opin Cardiol, 2004, vol. 19, no. 4, pp. 336-340.Susic D, Varagic J, Ahn J, Frohlich E.D. Crosslink breakers: a new approach to cardiovascular therapy. Curr Opin Cardiol, 2004, vol. 19, no. 4, pp. 336-340.Trisvetova Е.L. Zaschita sosudov pri arterial’noy gipertenzii – shag k snizheniyu riska razvitiya serdechno-sosudistych oslozhneniy [Vascular protection in arterial hypertension - step to reduce the risk of cardiovascular complications]. Medical News, 2017, no.11, pp. 3-7. (in Russin).Trisvetova Е.L. Zaschita sosudov pri arterial’noy gipertenzii – shag k snizheniyu riska razvitiya serdechno-sosudistych oslozhneniy [Vascular protection in arterial hypertension - step to reduce the risk of cardiovascular complications]. Medical News, 2017, no.11, pp. 3-7. (in Russin).LeBleu V.S., Macdonald B, Kalluri R. Structure and function of basement membranes. Exp Biol Med (Maywood), 2007, vol. 232, no. 9, pp. 1121-1129.LeBleu V.S., Macdonald B, Kalluri R. Structure and function of basement membranes. Exp Biol Med (Maywood), 2007, vol. 232, no. 9, pp. 1121-1129.Bolster B.D., Serfaty J.N., Atalar E. In vivo measurement of pulse wave velocity in small vessels using intravascular MR. Magn Reson Med, 2001, vol. 45, no. 1, pp. 53-60.Bolster B.D., Serfaty J.N., Atalar E. In vivo measurement of pulse wave velocity in small vessels using intravascular MR. Magn Reson Med, 2001, vol. 45, no. 1, pp. 53-60.Stettler C., Niederer P., Anliker M. Theoretical analysis of arterial hemodynamics including the influence of bifurcations. Part I: Mathematical model and prediction of normal pulse patterns. Ann Biomed Eng, 1981, vol. 9, pp. 145-164.Stettler C., Niederer P., Anliker M. Theoretical analysis of arterial hemodynamics including the influence of bifurcations. Part I: Mathematical model and prediction of normal pulse patterns. Ann Biomed Eng, 1981, vol. 9, pp. 145-164.Stojadinović B, Tenne T, Zikich D, Rajković N, Milošević N, Lazović B, Žikić D. Effect of viscosity on the wave propagation: Experimental determination of compression and expansion pulse wave velocity in fluid-fill elastic tube. J Biomech, 2015, vol. 48, no. 15, pp. 3969-3974.Stojadinović B, Tenne T, Zikich D, Rajković N, Milošević N, Lazović B, Žikić D. Effect of viscosity on the wave propagation: Experimental determination of compression and expansion pulse wave velocity in fluid-fill elastic tube. J Biomech, 2015, vol. 48, no. 15, pp. 3969-3974.Taylor C.A. Humphrey J.D. Open problems in computational vascular biomechanics: hemodynamics and arterial wall mechanics. Comput Methods Appl Mech Eng, 2009, vol. 198, pp. 3514-3523.Taylor C.A. Humphrey J.D. Open problems in computational vascular biomechanics: hemodynamics and arterial wall mechanics. Comput Methods Appl Mech Eng, 2009, vol. 198, pp. 3514-3523.Hollander, D. Durban, X. Lu, G. S. Kassab, Lanir Y. Constitutive modeling of coronary arterial media comparison of three model classes. J Biomech Eng, 2011, vol. 133, no. 6, pp. 061008.Hollander, D. Durban, X. Lu, G. S. Kassab, Lanir Y. Constitutive modeling of coronary arterial media comparison of three model classes. J Biomech Eng, 2011, vol. 133, no. 6, pp. 061008.Dobrin P.B., Caneld T. R. Elastase, collagenase, and the biaxial elastic properties of dog carotid artery. Am J Physiol, 1984, no. 2547, pp. H124-H131.Dobrin P.B., Caneld T. R. Elastase, collagenase, and the biaxial elastic properties of dog carotid artery. Am J Physiol, 1984, no. 2547, pp. H124-H131.Holzapfel G.A. Biomechanics of soft tissue. The Handbook of Materials Behavior Models, 2001, vol. 3, pp. 1049-1063.Holzapfel G.A. Biomechanics of soft tissue. The Handbook of Materials Behavior Models, 2001, vol. 3, pp. 1049-1063.Simsek F.G., Kwon Y.W. Investigation of material modeling in fluid–structure interaction analysis of an idealized three-layered abdominal aorta: aneurysm initiation and fully developed aneurysms. J Biol Phys, 2015, vol. 41, pp. 173-201.Simsek F.G., Kwon Y.W. Investigation of material modeling in fluid–structure interaction analysis of an idealized three-layered abdominal aorta: aneurysm initiation and fully developed aneurysms. J Biol Phys, 2015, vol. 41, pp. 173-201.

The authors declare that there are no conflicts of interest present.