emcardioНеотложная кардиология и кардиоваскулярные рискиEmergency Cardiology and Cardiovascular Risks journal2616-633XБелорусский государственный медицинский университет10.51922/2616-633X.2023.7.2.2021emcardio-20Research ArticleОбзоры и лекцииReviews and lecturesФиксированная комбинация ирбесартан/гидрохлортиазид в лечении артериальной гипертензииFixed-dose irbesartan/hydrochlorothiazide combination in the treatment of arterial hypertensionКожановаИ. Н.KozhanovaI. N.

Минск

Minsk

kozhanovairina@mail.ruБелорусский государственный медицинский университетBelarusian State Medical University2023190620257220212031Copyright © Кожанова И.Н., 20252025Кожанова И.Н.Kozhanova I.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://emcardio.bsmu.by/jour/article/view/20

В Республике Беларусь почти треть населения имеет повышенный уровень артериального давления, и соответственно подвергаются высокому риску развития сердечно-сосудистых заболеваний. Несмотря на доступность антигипертензивных препаратов, более 40% пациентов, получающих антигипертензивную терапию, не достигают целевых значений АД и остаются в зоне повышенного риска сердечно-сосудистых катастроф. Лекарственный препарат ирбесартан/гидрохлортиазид, включающий два действующих вещества в виде одной формы выпуска – таблетки, представляет собой сбалансированную на основе клинико-фармакологических свойств антигипертензивную комбинацию, одобренную Министерством здравоохранения Республики Беларусь для применения у пациентов по показанию: эссенциальная артериальная гипертензия. Эта комбинация с фиксированными дозами предназначена для взрослых пациентов, у которых артериальное давление недостаточно контролируется при монотерапии ирбесартаном или гидрохлортиазидом. Клиническая эффективность и безопасность данной комбинации была продемонстрирована в рандомизированных клинических исследованиях, в том числе у пациентов с сочетанием артериальной гипертензии и сахарного диабета 2 типа, метаболическим синдромом, ожирением. Применение комбинации ирбесартан/гидрохлортиазид в виде одной таблетки приводит к более быстрому снижению артериального давления по сравнению с монотерапией ирбесартаном, позволяет большей части пациентов с гипертонией достичь целевого значения артериального давления, повышает приверженность к терапии. Таким образом, комбинация ирбесартан/гидрохлортиазид является ценным дополнением к арсеналу клиницистов для лечения артериальной гипертензии.

Almost a third of the population of the Republic of Belarus suffers from elevated blood pressure which results in a high risk of cardiovascular disease developing. Despite the availability of numerous antihypertensive drugs, more than 40% of patients receiving antihypertensive therapy do not achieve target blood pressure levels and continue to be at an increased risk of cardiovascular events. A fixed combination drug irbesartan/hydrochlorothiazide, which includes two active ingredients in one dosage form of a tablet, is an antihypertensive combination balanced on the basis of clinical and pharmacological properties, which is approved by the Ministry of Health of the Republic of Belarus for use in patients when indicated in case of essential arterial hypertension. This fixed-dose combination is intended for adult patients whose blood pressure is not adequately controlled by irbesartan or hydrochlorothiazide monotherapy. The clinical efficacy and safety of this combination was demonstrated in randomized clinical trials, including patients with a combination of hypertension and type 2 diabetes, metabolic syndrome, and obesity. The use of the fixed-dose combination of irbesartan/hydrochlorothiazide leads to a more rapid decrease in blood pressure compared to irbesartan monotherapy, allows the majority of patients with severe hypertension to achieve the target blood pressure, and increases drug compliance. Thus, the irbesartan/hydrochlorothiazide combination is a valuable addition to clinicians’ armamentarium for the treatment of hypertension.

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The authors declare that there are no conflicts of interest present.