emcardioНеотложная кардиология и кардиоваскулярные рискиEmergency Cardiology and Cardiovascular Risks journal2616-633XБелорусский государственный медицинский университетemcardio-195Research ArticleОригинальные научные публикацииOriginal Scientific ResearchВзаимосвязь гипертрофии левого желудочка с нарушениями фильтрационной и тубулоинтерстициальной функций почек у пациентов с гипертонической болезньюCorrelation of left ventricular hypertrophy with impaired filtration and tubulointerstitial kidney function in patients with hypertensionЧернявинаА. И.ChernyavinaA. I.КозиоловаН. А.KoziolovaN. A.Пермский Государственный Медицинский Университет им. акад. Е.А. Вагнера Минздрава РоссииPerm State Medical University named after Academician E. A. Wagner20203010202541861–866Copyright © Чернявина А.И., Козиолова Н.А., 20252025Чернявина А.И., Козиолова Н.А.Chernyavina A.I., Koziolova N.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://emcardio.bsmu.by/jour/article/view/195

Цель исследования: выявить взаимосвязь гипертрофии левого желудочка (ГЛЖ) с формированием ранней ренальной дисфункции у больных неосложненной ГБ без ХБП.

Aim: to identify the correlation of left ventricular hypertrophy (LVH) with the development of early renal dysfunction in patients with uncomplicated HT without CKD

артериальная гипертензиягипертрофия левого желудочканарушение фильтрационной функции почекцистатин Сarterial hypertensionleft ventricular hypertrophyimpaired renal filtration functioncystatin CReferencesForouzanfar M.H., Liu P., Roth G.A., Ng M., Biryukov S., Marczak L., Alexander L., Estep K., Abate K.H., Akinyemiju T.F., Ali R., Alvis-Guzman N., Azzopardi P., Banerjee A., Bärnighausen T., Basu A., Bekele T. [et al.]. Global burden of hypertension and systolic blood pressure of at least 110 to 115 mm Hg, 1990-2015. JAMA, 2017, vol. 317, no. 2 pp. 165-182. doi: 10.1001/jama.2016.19043.Forouzanfar M.H., Liu P., Roth G.A., Ng M., Biryukov S., Marczak L., Alexander L., Estep K., Abate K.H., Akinyemiju T.F., Ali R., Alvis-Guzman N., Azzopardi P., Banerjee A., Bärnighausen T., Basu A., Bekele T. [et al.]. Global burden of hypertension and systolic blood pressure of at least 110 to 115 mm Hg, 1990-2015. JAMA, 2017, vol. 317, no. 2 pp. 165-182. doi: 10.1001/jama.2016.19043.Williams B., Mancia G., Spiering W., Rosei E.A., Azizi M., Burnier M., Clement D.L., Coca A., de Simone G., Dominiczak A., Kahan T. [et al.]. 2018 ESC/ESH Guidelines for the management of arterial hypertension. Eur Heart J., vol. 39, no. 33, pp. 3021-3104. doi: 10.1093/eurheartj/ehy339.Williams B., Mancia G., Spiering W., Rosei E.A., Azizi M., Burnier M., Clement D.L., Coca A., de Simone G., Dominiczak A., Kahan T. [et al.]. 2018 ESC/ESH Guidelines for the management of arterial hypertension. Eur Heart J., vol. 39, no. 33, pp. 3021-3104. doi: 10.1093/eurheartj/ehy339.Vel’kov V.V. Cistatin S i NGAL - markery’ preklinicheskoy renal’noy disfunkcii i subklinicheskogo ostrogo povrejdeniya pochek [Cystatin C and NGAL are markers of preclinical renal dysfunction and subclinical acute kidney injury]. Laboratornaya slujba, 2015, no. 2, pp. 38-43. doi: 10.17116/labs20154238-43. (in Russian).Vel’kov V.V. Cistatin S i NGAL - markery’ preklinicheskoy renal’noy disfunkcii i subklinicheskogo ostrogo povrejdeniya pochek [Cystatin C and NGAL are markers of preclinical renal dysfunction and subclinical acute kidney injury]. Laboratornaya slujba, 2015, no. 2, pp. 38-43. doi: 10.17116/labs20154238-43. (in Russian).Rysz J., Gluba-Brzózka A., Franczyk B., Jabłonowski Z., Ciałkowska-Rysz A. Novel Biomarkers in the Diagnosis of Chronic Kidney Disease and the Prediction of Its Outcome. Int J Mol Sci, 2017, vol. 18, no. 8, pp. 1702. doi: 10.3390/ijms18081702.Rysz J., Gluba-Brzózka A., Franczyk B., Jabłonowski Z., Ciałkowska-Rysz A. Novel Biomarkers in the Diagnosis of Chronic Kidney Disease and the Prediction of Its Outcome. Int J Mol Sci, 2017, vol. 18, no. 8, pp. 1702. doi: 10.3390/ijms18081702.Chernyavina A.I., Koziolova N.A., Mironova S.V. Renovazal’ny’e vzaimootnosheniya u bol’ny’h neoslojnennoy gipertonicheskoy bolezn’yu [Renovalia relationship in patients with uncomplicated hypertension]. Perm. med. jurn, 2019, vol. 36, no. 4, pp. 5-12. doi: 10.17816/pmj3645-12. (in Russian).Chernyavina A.I., Koziolova N.A., Mironova S.V. Renovazal’ny’e vzaimootnosheniya u bol’ny’h neoslojnennoy gipertonicheskoy bolezn’yu [Renovalia relationship in patients with uncomplicated hypertension]. Perm. med. jurn, 2019, vol. 36, no. 4, pp. 5-12. doi: 10.17816/pmj3645-12. (in Russian).Nitta K., Iimuro S., Imai E., Matsuo S., Makino H., Akizawa T., Watanabe T., Ohashi Y., Hishida A. Risk factors for increased left ventricular hypertrophy in patients with chronic kidney disease: findings from the CKD-JAC study. Clin Exp Nephrol, 2017, vol. 21, no. 6, pp. 1146. doi.org/10.1007/s10157-018-1624-9.Nitta K., Iimuro S., Imai E., Matsuo S., Makino H., Akizawa T., Watanabe T., Ohashi Y., Hishida A. Risk factors for increased left ventricular hypertrophy in patients with chronic kidney disease: findings from the CKD-JAC study. Clin Exp Nephrol, 2017, vol. 21, no. 6, pp. 1146. doi.org/10.1007/s10157-018-1624-9.Amoako Y.A., Laryea D.O., Bedu-Addo G., Nkum B.C., Plange-Rhule J. Lef t ventricular hypertrophy among chronic kidney disease patients in Ghana. Pan Afr Med J, 2017, vol. 28, no. 6, pp. 79. doi:10.11604/pamj.2017.28.79.9183.Amoako Y.A., Laryea D.O., Bedu-Addo G., Nkum B.C., Plange-Rhule J. Lef t ventricular hypertrophy among chronic kidney disease patients in Ghana. Pan Afr Med J, 2017, vol. 28, no. 6, pp. 79. doi:10.11604/pamj.2017.28.79.9183.Angeli F., Ambrosio G. Mechanisms of Left Ventricular Hypertrophy in 9. Hypertension: More than Just Blood Pressure. Rev Argent Cardiol, 2015, vol. 83, pp. 5-6. doi.org/10.7775.rac.v83.i1.5771.Angeli F., Ambrosio G. Mechanisms of Left Ventricular Hypertrophy in 9. Hypertension: More than Just Blood Pressure. Rev Argent Cardiol, 2015, vol. 83, pp. 5-6. doi.org/10.7775.rac.v83.i1.5771.Thomas R., eds. Chronic Kidney Disease: from Pathophysiology to Clinical Improvements [electronic resource]. Available at: https://www.intechopen.com/books/chronic-kidney-disease-from-pathophysiology-to-clinical-improvements. (accessed 28.03.2020). doi: 10.5772/intechopen.69574.Thomas R., eds. Chronic Kidney Disease: from Pathophysiology to Clinical Improvements [electronic resource]. Available at: https://www.intechopen.com/books/chronic-kidney-disease-from-pathophysiology-to-clinical-improvements. (accessed 28.03.2020). doi: 10.5772/intechopen.69574.Rangaswami J., Bhalla V., Blair J., Chang T.I., Costa S., Lentine K.L, Lerma E.V, Mezue K., Molitch M., Mullens W., Ronco C., Tang W.H.W., McCullough P.A. Cardiorenal Syndrome: Classification, Pathophysiology, Diagnosis, and Treatment Strategies: A Scientific Statement From the American Heart Association. Circulation, 2019, vol. 139, no. 16, pp. e840-e878. doi.org/10.1161/CIR.0000000000000664.Rangaswami J., Bhalla V., Blair J., Chang T.I., Costa S., Lentine K.L, Lerma E.V, Mezue K., Molitch M., Mullens W., Ronco C., Tang W.H.W., McCullough P.A. Cardiorenal Syndrome: Classification, Pathophysiology, Diagnosis, and Treatment Strategies: A Scientific Statement From the American Heart Association. Circulation, 2019, vol. 139, no. 16, pp. e840-e878. doi.org/10.1161/CIR.0000000000000664.Di Lullo L., Bellasi А., Barbera V., Russo D., Russo L., Di Iorio B., Cozzolino M., Ronco C. Pathophysiology of the cardio-renal syndromes types 1-5: An uptodate. Indian Heart J, 2017, vol. 69, no. 2, pp. 255-265. doi.org/10.1016/j.ihj.2017.01.005.Di Lullo L., Bellasi А., Barbera V., Russo D., Russo L., Di Iorio B., Cozzolino M., Ronco C. Pathophysiology of the cardio-renal syndromes types 1-5: An uptodate. Indian Heart J, 2017, vol. 69, no. 2, pp. 255-265. doi.org/10.1016/j.ihj.2017.01.005.Leibowitz D. Left ventricular hypertrophy and chronic renal insufficiency in the elderly. Cardiorenal Med, 2014, vol. 4, pp. 168-175. doi:10.1159/000366455.Leibowitz D. Left ventricular hypertrophy and chronic renal insufficiency in the elderly. Cardiorenal Med, 2014, vol. 4, pp. 168-175. doi:10.1159/000366455.Cao С., Hu J-X., Dong Y-F., Zhan R., Li P., Su H., Peng Q., Wu T., Huang X., Sun W.-H., Wu Q.-H., Cheng X.-S.. Association of Endothelial and Mild Renal Dysfunction With the Severity of Left Ventricular Hypertrophy in Hypertensive Patients. Am J Hypertens, 2016, vol. 29, no. 4, pp. 501-508. doi.org/10.1093/ajh/hpv128.Cao С., Hu J-X., Dong Y-F., Zhan R., Li P., Su H., Peng Q., Wu T., Huang X., Sun W.-H., Wu Q.-H., Cheng X.-S.. Association of Endothelial and Mild Renal Dysfunction With the Severity of Left Ventricular Hypertrophy in Hypertensive Patients. Am J Hypertens, 2016, vol. 29, no. 4, pp. 501-508. doi.org/10.1093/ajh/hpv128.Kim I.Y., Kim J.H., Kim M.J., Lee D.W., Hwang C.G., Han M., Rhee H., Song S.H., Seong E.Y., Lee S.B. Plasma neutrophil gelatinase-associated lipocalin is independently associated with lef t ventricular hyper trophy and diastolic dysfunction in patients with chronic kidney disease. PLoS One, 2018, vol. 13, no. 10, pp. e0205848. doi:10.1371/journal.pone.0205848.Kim I.Y., Kim J.H., Kim M.J., Lee D.W., Hwang C.G., Han M., Rhee H., Song S.H., Seong E.Y., Lee S.B. Plasma neutrophil gelatinase-associated lipocalin is independently associated with lef t ventricular hyper trophy and diastolic dysfunction in patients with chronic kidney disease. PLoS One, 2018, vol. 13, no. 10, pp. e0205848. doi:10.1371/journal.pone.0205848.

The authors declare that there are no conflicts of interest present.