emcardioНеотложная кардиология и кардиоваскулярные рискиEmergency Cardiology and Cardiovascular Risks journal2616-633XБелорусский государственный медицинский университет10.51922/2616-633X.2023.7.2.2033emcardio-19Research ArticleОбзоры и лекцииReviews and lecturesГидрогель на основе хитозана и наночастиц теллура (CS/TE) – основные характеристики и перспективы применения новой эффективной антибактериальной платформыTellurium-based chitosan hydrogel as an efficient NIR-induced antibacterial platformЛейцзяоЛиLeijiaoLi

Чанчунь

Чжуншань

Changchun

Zhongshan

ШестаковаЛ.ShestakovaL.

Минск

Minsk

shestakova@hotmail.comЦзяньсуньДинJianxunDing

Чанчунь

Changchun

ТяньмэнСунTianmengSun

Чанчунь

Changchun

ВэньлянЛиWenliangLi

Чанчунь

Чжуншань

Changchun

Zhongshan

ОстровскийЮ.OstrovskYu.

Минск

Minsk

Чанчуньский университет науки и техники; Чжуншаньский институт, Чанчуньский университет науки и техникиChangchun University of Science and Technology; Zhongshan Institute, Changchun University of Science and TechnologyРеспубликанский научно-практический центр «Кардиология»Belarusian State Scientific and Practical Center of CardiologyЧанчуньский институт прикладной химии Академии наук КитаяChangchun Institute of Applied Chemistry, Chinese Academy of SciencesЛаборатория регенерации и трансплантации органов Министерства образования, Институт иммунологии, Первая больница, Цзилиньский университетKey Laboratory of Organ Regeneration and Transplantation of Ministry of Education, Institute of Immunology, The First Hospital, Jilin University2023190620257220332040Copyright © Лейцзяо Л., Шестакова Л., Цзяньсунь Д., Тяньмэн С., Вэньлян Л., Островский Ю., 20252025Лейцзяо Л., Шестакова Л., Цзяньсунь Д., Тяньмэн С., Вэньлян Л., Островский Ю.Leijiao L., Shestakova L., Jianxun D., Tianmeng S., Wenliang L., Ostrovsk Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://emcardio.bsmu.by/jour/article/view/19

Появление устойчивости к антибиотикам потребовало разработки новых противомикробных методов лечения. Согласно описанным в литературе данным, композиты полимер-металл демонстрируют антибактериальную и антибиопленочную активность против E. Сoli и S. Еnterica. Кроме того, наночастицы теллура (Te NPs) обладают значительной активность по улавливанию свободных радикалов ABTS и DPPH, демонстрируют цитотоксичность в отношении раковых клеток (A549 и PC3) по сравнению с нормальными клетками (клетками NIH3T3). В этой статье описан процесс получения наночастиц теллура в форме бабочки, которые обладают хорошей биосовместимостью. Их однородный размер составляет около 200 нм, а эффективность их фототермического преобразования (η) достигает 52,9%. Для получения гидрогеля хитозана (CS / ГХ) с губчатой структурой, обладающего превосходной пористостью и растворимостью, был использован метод двунаправленного замораживания. Пористость субстрата превышает 75% и может сохранять увлажняющий эффект около 16 часов. Подготовленные наночастицы теллура вводили в гидрогель хитозана для создания антибактериальной платформы CS/Te, которая продемонстрировала эффективность против золотистого стафилококка (S. Аureus) и кишечной палочки (E. Сoli). Приведенные результаты позволяют предположить, что антибактериальная платформа CS/Te может стать перспективным антибактериальным материалом, для биомедицинских применений.

A kind of butterfly-shaped tellurium nanoparticles (Te NPs) is prepared in this paper, which have good biocompatibility, their uniform size is about 200 nm, and their photothermal conversion efficiency (η) is as high as 52.9%. Subsequently, a bidirectional freezing method was used to prepare a chitosan hydrogel (CS) with a sponge-like structure, which has excellent porosity and solubility. Its porosity exceeds 75% and can maintain a moisturizing effect for about 16 hours. Then, the prepared Te NPs were introduced into CS to construct a CS/Te antibacterial platform, which was effective against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). These results suggested that CS/Te antibacterial platform could be a promising NIR light-activated antibacterial candidate material for biomedical applications.

наночастицы теллурагидрогель на основе хитозанаантибактериальный материал хитозан/теллур (CS/TE)tellurium nanoparticles (Te NPs)chitosan hydrogel (CS)antibacterial platform CS/TEThis work was partially financially supported by the Science and Technology Research Project of Jilin Education Bureau (No. JJKH20230804KJ).ReferencesE M Tottoli, R Dorati, I Genta, et al. Skin Wound Healing Process and New Emerging Technologies for Skin Wound Care and Regeneration[J]. Pharmaceutics, 2020(8): 735.E M Tottoli, R Dorati, I Genta, et al. Skin Wound Healing Process and New Emerging Technologies for Skin Wound Care and Regeneration[J]. Pharmaceutics, 2020(8): 735.S Kirchner, V Lei, A S MacLeod. The Cutaneous Wound Innate Immunological Microenvironment[ J]. International Journal of Molecular Sciences, 2020, 21(22): 8748.S Kirchner, V Lei, A S MacLeod. The Cutaneous Wound Innate Immunological Microenvironment[ J]. International Journal of Molecular Sciences, 2020, 21(22): 8748.Lu Huidan, Tu Chenxi, Zhou Tong, et al. A ROS-scavenging hydrogel loaded with bacterial quorum sensing inhibitor hyperbranched poly-L-lysine promotes the wound scar-free healing of infected skin in vivo[J]. Chemical Engineering Journal, 2022, 436: 135130.Lu Huidan, Tu Chenxi, Zhou Tong, et al. A ROS-scavenging hydrogel loaded with bacterial quorum sensing inhibitor hyperbranched poly-L-lysine promotes the wound scar-free healing of infected skin in vivo[J]. Chemical Engineering Journal, 2022, 436: 135130.M Bulut, A D Kucuk, A Bulut, et al. Evaluation of accidental and intentional pediatric poisoning: Retrospective analysis in an emergency Department of Turkey[J]. Journal of pediatric nursing care of Children&Families, 2022, 63: 44-49.M Bulut, A D Kucuk, A Bulut, et al. Evaluation of accidental and intentional pediatric poisoning: Retrospective analysis in an emergency Department of Turkey[J]. Journal of pediatric nursing care of Children&Families, 2022, 63: 44-49.Yang Yuxuan, Zhao Xiaodan, Yu Jing, et al. Bioactive skin-mimicking hydrogel band-aids for diabetic wound healing and infectious skin incision treatment[J]. Bioactive Materials, 2021, 6(11): 3962-3975.Yang Yuxuan, Zhao Xiaodan, Yu Jing, et al. Bioactive skin-mimicking hydrogel band-aids for diabetic wound healing and infectious skin incision treatment[J]. Bioactive Materials, 2021, 6(11): 3962-3975.Xue Meilang, Zhao Ruilong, et al. Delivery systems of current biologicals for the treatment of chronic cutaneous wounds and severe burns[J]. Advanced Drug Delivery Reviews, 2018, 129: 219-241.Xue Meilang, Zhao Ruilong, et al. Delivery systems of current biologicals for the treatment of chronic cutaneous wounds and severe burns[J]. Advanced Drug Delivery Reviews, 2018, 129: 219-241.J Dissemond, M Romanelli. Inflammatory skin diseases and wounds[J]. British Journal of Dermatology, 2022, 187(2): 167-177.J Dissemond, M Romanelli. Inflammatory skin diseases and wounds[J]. British Journal of Dermatology, 2022, 187(2): 167-177.S W Gerdin, A Lie, A Asarnoj, et al. Impaired skin barrier and allergic sensitization in early infancy[J]. Allergy, 2021, 77(5): 1464-1476.S W Gerdin, A Lie, A Asarnoj, et al. Impaired skin barrier and allergic sensitization in early infancy[J]. Allergy, 2021, 77(5): 1464-1476.S G Danby, P V Andrew, L J Kay, et al. Enhancement of stratum corneum lipid structure improves skin barrier function and protects against irritation in adults with dry, eczema-prone skin[J]. British Journal of Dermatology, 2022, 186(5): 875-886.S G Danby, P V Andrew, L J Kay, et al. Enhancement of stratum corneum lipid structure improves skin barrier function and protects against irritation in adults with dry, eczema-prone skin[J]. British Journal of Dermatology, 2022, 186(5): 875-886.Zeng Qiankun, Qi Xiaoliang, Shi Guoyue, et al. Wound Dressing: From Nanomaterials to Diagnostic Dressings and Healing Evaluations[J]. ACS NANO, 2022, 16(2): 1708-1733.Zeng Qiankun, Qi Xiaoliang, Shi Guoyue, et al. Wound Dressing: From Nanomaterials to Diagnostic Dressings and Healing Evaluations[J]. ACS NANO, 2022, 16(2): 1708-1733.Huo Jingjing, Jia Qingyan, Huang Han, et al. Emerging photothermal-derived multimodal synergistic therapy in combating bacterial infections[J]. Chemical Society Reviews, 2021, 50(15): 8762-8789.Huo Jingjing, Jia Qingyan, Huang Han, et al. Emerging photothermal-derived multimodal synergistic therapy in combating bacterial infections[J]. Chemical Society Reviews, 2021, 50(15): 8762-8789.Xi Dongmei, Xiao Ming, Cao Jianfang, et al. NIR Light-Driving Barrier-Free Group Rotation in Nanoparticles with an 88.3% Photothermal Conversion Efficiency for Photothermal Therapy[J]. Advanced Materials, 2020, 32(11): 19078551.Xi Dongmei, Xiao Ming, Cao Jianfang, et al. NIR Light-Driving Barrier-Free Group Rotation in Nanoparticles with an 88.3% Photothermal Conversion Efficiency for Photothermal Therapy[J]. Advanced Materials, 2020, 32(11): 19078551.A S Montaser, M Rehan, W M El-Senousy, et al. Designing strategy for coating cotton gauze fabrics and its application in wound healing[J]. Carbohydrate Polymers, 2020, 244: 116479.A S Montaser, M Rehan, W M El-Senousy, et al. Designing strategy for coating cotton gauze fabrics and its application in wound healing[J]. Carbohydrate Polymers, 2020, 244: 116479.A Abedin-Do, Zhang Ze, Y Douville, et al. Electrical stimulation promotes the wound-healing properties of diabetic human skin fibroblasts[J]. Journal of Tissue Engineering and Regenerative Medicine, 2022, 16(7): 643-652.A Abedin-Do, Zhang Ze, Y Douville, et al. Electrical stimulation promotes the wound-healing properties of diabetic human skin fibroblasts[J]. Journal of Tissue Engineering and Regenerative Medicine, 2022, 16(7): 643-652.Xu Xiaowen, V V Jerca, R Hoogenboom. Bioinspired double network hydrogels: From covalent double network hydrogels via hybrid double network hydro- gels to physical double network hydrogels[J]. Materials Horizons, 2020, 8(4): 1173-1188.Xu Xiaowen, V V Jerca, R Hoogenboom. Bioinspired double network hydrogels: From covalent double network hydrogels via hybrid double network hydro- gels to physical double network hydrogels[J]. Materials Horizons, 2020, 8(4): 1173-1188.Duan Yumeng, Li Kaiyue, Wang Huangwei, et al. Preparation and evaluation of curcumin grafted hyaluronic acid modified pullulan polymers as a functional wound dressing material[J]. Carbohydrate Polymers, 2020, 238: 116195.Duan Yumeng, Li Kaiyue, Wang Huangwei, et al. Preparation and evaluation of curcumin grafted hyaluronic acid modified pullulan polymers as a functional wound dressing material[J]. Carbohydrate Polymers, 2020, 238: 116195.

The authors declare that there are no conflicts of interest present.