<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">emcardio</journal-id><journal-title-group><journal-title xml:lang="ru">Неотложная кардиология и кардиоваскулярные риски</journal-title><trans-title-group xml:lang="en"><trans-title>Emergency Cardiology and Cardiovascular Risks journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2616-633X</issn><publisher><publisher-name>Белорусский государственный медицинский университет</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">emcardio-184</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Обзоры и лекции</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Reviews and lectures</subject></subj-group></article-categories><title-group><article-title>Стратегия оценки рисков и профилактики тромбоэмболических осложнений у пациентов нейрохирургического профиля</article-title><trans-title-group xml:lang="en"><trans-title>Risk assessment and venous thromboembolism prophylaxis strategy in neurosurgical patients</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гавриленко</surname><given-names>Л. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Gavrilenko</surname><given-names>L. N.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Романова</surname><given-names>И. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Romanova</surname><given-names>I. S.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кожанова</surname><given-names>И. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Kozhanova</surname><given-names>I. N.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Садовская</surname><given-names>О. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Sadovskaya</surname><given-names>O. G.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Барановский</surname><given-names>А. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Baranovsky</surname><given-names>A. E.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Белорусский государственный медицинский университет</institution></aff><aff xml:lang="en"><institution>Belarusian State Medical University</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>4-я городская клиническая больница им. Н.Е.Савченко</institution></aff><aff xml:lang="en"><institution>4th City Clinical Hospital named after N.E.Savchenko</institution></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>5-я городская клиническая больница</institution></aff><aff xml:lang="en"><institution>5th City Clinical Hospital</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>30</day><month>10</month><year>2025</year></pub-date><volume>4</volume><issue>1</issue><elocation-id>909–916</elocation-id><permissions><copyright-statement>Copyright &amp;#x00A9; Гавриленко Л.Н., Романова И.С., Кожанова И.Н., Садовская О.Г., Барановский А.Е., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Гавриленко Л.Н., Романова И.С., Кожанова И.Н., Садовская О.Г., Барановский А.Е.</copyright-holder><copyright-holder xml:lang="en">Gavrilenko L.N., Romanova I.S., Kozhanova I.N., Sadovskaya O.G., Baranovsky A.E.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://emcardio.bsmu.by/jour/article/view/184">https://emcardio.bsmu.by/jour/article/view/184</self-uri><abstract><p>Смертность от венозных тромбоэмболических осложнений (ВТЭО) составляет около 25000 смертей в год в Великобритании. В США около трети из 150-200 тыс. смертей, ассоциированных с тромбоэмболиями, происходит после операции. Риск ВТЭО у пациентов нейрохирургического профиля широко варьирует в зависимости от вида хирургического вмешательства, состояния пациента, наличия сопутствующей патологии, использования различных методов тромбопрофилактики. Особенности пациентов нейрохирургического профиля (высокая частота гиповолемии и гемоконцентрации, распространенность параличей и парезов, использование высоких доз глюкокортикоидов, большая длительность оперативных вмешательств), высокий риск кровотечений при использовании фармакологических методов профилактики, а также отсутствие достаточного количества исследований высокого качества требуют выработки единого подхода к тромбопрофилактике в нейрохирургии. В данной статье представлена стратегия профилактики ВТЭО у пациентов нейрохирургического профиля, разработанная авторами на основании актуальных международных рекомендаций.</p></abstract><trans-abstract xml:lang="en"><p>Venous thromboembolism (VTE) causes 25,000 in-hospital deaths every year in the United Kingdom. Approximately one-third of the total of 150,000 to 200,000 of VTE-related deaths per year in the United States occur following surgery. The VTE risk varies widely in neurosurgical patients depending on the type of intervention, the patient’s condition, comorbidity, and methods of thromboprophylaxis used. Neurosurgical patients’ characteristics (high prevalence of hypovolemia and hemoconcentration, paralysis and paresis, the use of high doses of glucocorticoids, the long duration of surgical interventions), high bleeding risk associated with pharmacological prophylaxis, and relatively few high-quality studies require development of a uniform decision-making approach regarding thromboprophylaxis in neurosurgery. This article presents a VTE prophylaxis strategy in neurosurgical patients developed on the basis of the latest international guidelines.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>венозные тромбоэмболические осложнения</kwd><kwd>профилактика</kwd><kwd>нейрохирургия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>venous thromboembolism</kwd><kwd>prophylaxis</kwd><kwd>neurosurgery</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Elshazly S., Ames S. Prevention and treatment of venous thrombo-embolism (vte): risk assessment and prophylaxis. NICE Clinical Guideline, 2019.</mixed-citation><mixed-citation xml:lang="en">Elshazly S., Ames S. Prevention and treatment of venous thrombo-embolism (vte): risk assessment and prophylaxis. NICE Clinical Guideline, 2019.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Gould M.K., Garcia D.A., Wren S.M., Karanicolas P.J., Arcelus J.I., Heit J.A., Samama C.M. Prevention of VTE in Nonorthopedic Surgical Patients Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical: Practice Guidelines. Chest, 2012, vol. 141, Suppl 2, pp. e227s-e277s.</mixed-citation><mixed-citation xml:lang="en">Gould M.K., Garcia D.A., Wren S.M., Karanicolas P.J., Arcelus J.I., Heit J.A., Samama C.M. Prevention of VTE in Nonorthopedic Surgical Patients Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical: Practice Guidelines. Chest, 2012, vol. 141, Suppl 2, pp. e227s-e277s.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Faraoni D., Comes R.F., Geerts W., Wiles M.D. European guidelines on perioperative venous thromboembolism prophylaxis: Neurosurgery: Practice Guidelines. Eur J Anaesthesiol. 2018, vol. 35, no. 2, pp. 90-95.</mixed-citation><mixed-citation xml:lang="en">Faraoni D., Comes R.F., Geerts W., Wiles M.D. European guidelines on perioperative venous thromboembolism prophylaxis: Neurosurgery: Practice Guidelines. Eur J Anaesthesiol. 2018, vol. 35, no. 2, pp. 90-95.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Tacconi L, Spinelli R, Manganotti P. The prevention of deep venous thrombosis in neurosurgery: an update from our institution. Euromediterranean Biomed J, 2018, vol. 13, no. 36, pp. 160-163.</mixed-citation><mixed-citation xml:lang="en">Tacconi L, Spinelli R, Manganotti P. The prevention of deep venous thrombosis in neurosurgery: an update from our institution. Euromediterranean Biomed J, 2018, vol. 13, no. 36, pp. 160-163.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Bryson D.J., Uzoigwe C.E., Braybrooke J. Thromboprophylaxis in spinal surgery: a survey. J Orthop Surg Res, 2012, vol. 7, no. 1, pp. 14. doi: 10.1186/1749-799X-7-14.</mixed-citation><mixed-citation xml:lang="en">Bryson D.J., Uzoigwe C.E., Braybrooke J. Thromboprophylaxis in spinal surgery: a survey. J Orthop Surg Res, 2012, vol. 7, no. 1, pp. 14. doi: 10.1186/1749-799X-7-14.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Rolston J.D., Han S.J., Bloch O., Parsa A.T. What clinical factors predict the incidence of deep venous thrombosis and pulmonary embolism in neurosurgical patients? J Neurosurg, 2014, vol. 121, no. 4, pp. 908-918.</mixed-citation><mixed-citation xml:lang="en">Rolston J.D., Han S.J., Bloch O., Parsa A.T. What clinical factors predict the incidence of deep venous thrombosis and pulmonary embolism in neurosurgical patients? J Neurosurg, 2014, vol. 121, no. 4, pp. 908-918.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Lieber B.A., Han J., Appelboom G., Taylor B.E.S., Han B.J., Agarwal N., Connolly E.S.Jr. Association of Steroid Use with Deep Venous Thrombosis and Pulmonary Embolism in Neurosurgical Patients: A National Database Analysis. World Neurosurg, 2016, vol. 89, pp. 126-132.</mixed-citation><mixed-citation xml:lang="en">Lieber B.A., Han J., Appelboom G., Taylor B.E.S., Han B.J., Agarwal N., Connolly E.S.Jr. Association of Steroid Use with Deep Venous Thrombosis and Pulmonary Embolism in Neurosurgical Patients: A National Database Analysis. World Neurosurg, 2016, vol. 89, pp. 126-132.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Bekelis K., Labropoulos N., Coy S. Risk of Venous Thromboembolism and Operative Duration in Patients Undergoing Neurosurgical Procedures. Neurosurgery, 2017, vol. 80, no. 5, pp. 787-792.</mixed-citation><mixed-citation xml:lang="en">Bekelis K., Labropoulos N., Coy S. Risk of Venous Thromboembolism and Operative Duration in Patients Undergoing Neurosurgical Procedures. Neurosurgery, 2017, vol. 80, no. 5, pp. 787-792.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Anderson D.R., Morgano G.P., Bennett C., Dentali F., Francis C.W., Garcia D.A., Kahn S.R., Rahman M., Rajasekhar A., Rogers F.B., Smythe M.A. et al. American Society of Hematology 2019 guidelines for management of venous thromboembolism: prevention of venous thromboembolism in surgical hospitalized patients. Blood Adv, 2019, vol. 3, no. 23, pp. 3898-3944.</mixed-citation><mixed-citation xml:lang="en">Anderson D.R., Morgano G.P., Bennett C., Dentali F., Francis C.W., Garcia D.A., Kahn S.R., Rahman M., Rajasekhar A., Rogers F.B., Smythe M.A. et al. American Society of Hematology 2019 guidelines for management of venous thromboembolism: prevention of venous thromboembolism in surgical hospitalized patients. Blood Adv, 2019, vol. 3, no. 23, pp. 3898-3944.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Raksin P.B., Harrop J.S., Anderson P.A. Сongress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines on the Evaluation and Treatment of Patients With Thoracolumbar Spine Trauma: Prophylaxis and Treatment of Thromboembolic Events. Neurosurgery, 2019, vol. 84, no. 1, pp. E39-E42.</mixed-citation><mixed-citation xml:lang="en">Raksin P.B., Harrop J.S., Anderson P.A. Сongress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines on the Evaluation and Treatment of Patients With Thoracolumbar Spine Trauma: Prophylaxis and Treatment of Thromboembolic Events. Neurosurgery, 2019, vol. 84, no. 1, pp. E39-E42.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Guideline for the Prevention of Venous Thromboembolism (VTE) in Adult Hospitalised Patients. State of Queensland (Queensland Health), December 2018, 57 p.</mixed-citation><mixed-citation xml:lang="en">Guideline for the Prevention of Venous Thromboembolism (VTE) in Adult Hospitalised Patients. State of Queensland (Queensland Health), December 2018, 57 p.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Caprini J.A., Arcelus J.I., Hasty J.H., Tamhane A.C., Fabrega F. Clinical assessment of venous thromboembolic risk in surgical patients. Semin Thromb Hemost, 1991, vol. 1703, pp. 304-312.</mixed-citation><mixed-citation xml:lang="en">Caprini J.A., Arcelus J.I., Hasty J.H., Tamhane A.C., Fabrega F. Clinical assessment of venous thromboembolic risk in surgical patients. Semin Thromb Hemost, 1991, vol. 1703, pp. 304-312.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Rogers S.O.Jr., Kilaru R.K., Hosokawa P., Henderson W.G., Zinner M.J., Khuri S.F. Multivariable predictors of postoperative venous thromboembolic events after general and vascular surgery: results from the patient safety in surgery study. J Am Coll Surg, 2007, vol. 204, no. 6, pp. 1211-1221.</mixed-citation><mixed-citation xml:lang="en">Rogers S.O.Jr., Kilaru R.K., Hosokawa P., Henderson W.G., Zinner M.J., Khuri S.F. Multivariable predictors of postoperative venous thromboembolic events after general and vascular surgery: results from the patient safety in surgery study. J Am Coll Surg, 2007, vol. 204, no. 6, pp. 1211-1221.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Chibbaro S, Tacconi L. Safety of deep venous thrombosis prophylaxis with low-molecular-weight heparin in brain surgery. Surgical Neurology, 2008, vol. 70, no. 2, pp. 117-121.</mixed-citation><mixed-citation xml:lang="en">Chibbaro S, Tacconi L. Safety of deep venous thrombosis prophylaxis with low-molecular-weight heparin in brain surgery. Surgical Neurology, 2008, vol. 70, no. 2, pp. 117-121.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Song AB, Rosovsky RP, Connors JM, Al-Samkari H. Direct oral anticoagulants for treatment and prevention of venous thromboembolism in cancer patients. Vascular Health and Risk Management, 2019, vol. 15, pp. 175-186.</mixed-citation><mixed-citation xml:lang="en">Song AB, Rosovsky RP, Connors JM, Al-Samkari H. Direct oral anticoagulants for treatment and prevention of venous thromboembolism in cancer patients. Vascular Health and Risk Management, 2019, vol. 15, pp. 175-186.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Kirchhof P., Benussi S., Kotecha D., Ahlsson A., Atar D., Casadei B., Castella M., Diener H.-C., Heidbuchel H., Hendriks J., et al. 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. Eur Heart J, 2016, vol. 37, no. 38, pp. 2893-2962.</mixed-citation><mixed-citation xml:lang="en">Kirchhof P., Benussi S., Kotecha D., Ahlsson A., Atar D., Casadei B., Castella M., Diener H.-C., Heidbuchel H., Hendriks J., et al. 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. Eur Heart J, 2016, vol. 37, no. 38, pp. 2893-2962.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Steffel J., Verhamme P., Potpara T.S., Albaladejo P., Antz M., Desteghe L., Haeusler K.G., Oldgren J., Reinecke H., Roldan-Schilling V., Rowell N., Sinnaeve P., Collins R. et al. The 2018 European Heart Rhythm Association Practical Guide on the use of non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation. Eur Heart J, 2018, vol. 39, no. 16, pp. 1330-1393.</mixed-citation><mixed-citation xml:lang="en">Steffel J., Verhamme P., Potpara T.S., Albaladejo P., Antz M., Desteghe L., Haeusler K.G., Oldgren J., Reinecke H., Roldan-Schilling V., Rowell N., Sinnaeve P., Collins R. et al. The 2018 European Heart Rhythm Association Practical Guide on the use of non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation. Eur Heart J, 2018, vol. 39, no. 16, pp. 1330-1393.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Buryachkovskaya L.I., Lomakin N.V., Sumarokov A.B., Shirokov E.A. Effektivnost i bezopasnost antitromboticheskoy terapii. Shkaly i algoritmy. Klinicheskie rekomen-dazii. [Efficacy and safety of antithrombotic therapy. Scales and algorithms. National recommendations]. Moscow, 2018. 147 p. (in Russian).</mixed-citation><mixed-citation xml:lang="en">Buryachkovskaya L.I., Lomakin N.V., Sumarokov A.B., Shirokov E.A. Effektivnost i bezopasnost antitromboticheskoy terapii. Shkaly i algoritmy. Klinicheskie rekomen-dazii. [Efficacy and safety of antithrombotic therapy. Scales and algorithms. National recommendations]. Moscow, 2018. 147 p. (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Potopova I.I., Rusalenko M.G., Evsejchik E.S., Kononova O.N. Primenenie antikoagulyantov v klinicheskoy praktike: prakticheskoe posobie dlya vrachey [The use of anticoagulants in clinical practice. Practical guide for doctors]. Gomel 2018. 40 p. (in Russian).</mixed-citation><mixed-citation xml:lang="en">Potopova I.I., Rusalenko M.G., Evsejchik E.S., Kononova O.N. Primenenie antikoagulyantov v klinicheskoy praktike: prakticheskoe posobie dlya vrachey [The use of anticoagulants in clinical practice. Practical guide for doctors]. Gomel 2018. 40 p. (in Russian).</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
