emcardioНеотложная кардиология и кардиоваскулярные рискиEmergency Cardiology and Cardiovascular Risks journal2616-633XБелорусский государственный медицинский университетemcardio-183Research ArticleОбзоры и лекцииReviews and lecturesВозможности холина и его метаболита в коррекции гипергомоцистеинемии и снижении развития сердечно-сосудистой патологииCholin and its metabolite feasibilities in hyperhomocysteinemia correction and cardiovascular pathology decreaseПанасюкО. В.PanasiukO. V.МогилевецЭ. В.MogilevetsE. V.НаумовА. М.NaumovA. V.Гродненский государственный медицинский университетGrodno State Medical University20203010202541904–908Copyright © Панасюк О.В., Могилевец Э.В., Наумов А.М., 20252025Панасюк О.В., Могилевец Э.В., Наумов А.М.Panasiuk O.V., Mogilevets E.V., Naumov A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://emcardio.bsmu.by/jour/article/view/183

Гомоцистеин является цито- и нейротоксичной аминокислотой. Повышение его уровня в плазме крови называется гипергомоцистеинемией. Данное патологическое состояние способствует развитию и прогрессирующему течению сердечно-сосудистых заболеваний. Утилизация гомоцистеина заключается в его транссульфурировании в цистеин, или реметилировании в метионин. Повышенное поступление в организм холина и его метаболита (бетаина) ведёт к усилению процессов реметилирования и уменьшению уровня гомоцистеина в плазме крови. Следовательно, холин и бетаин могут рассматриваться в качестве веществ, способных воздействовать на гипергомоцистеинемию, и снижать развитие сердечно-сосудистых заболеваний

Homocysteine is a cyto- and neurotoxic amino acid. The raise of its level in blood plasma is called hyperhomocysteinemia. This pathological state leads to the development and progressive course of cardiovascular diseases. Homocysteine utilization involves its transulfurization to cysteine or remethylation to methionine. Choline and its metabolite (betaine) increased intake leads to enhanced processes of remethylation and decreased homocysteine level in blood plasma. Thus, choline and betaine may be considered as substances capable of influencing hyperhomo-cysteinemia and lowering the level of cardiovascular disease development.

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The authors declare that there are no conflicts of interest present.