emcardioНеотложная кардиология и кардиоваскулярные рискиEmergency Cardiology and Cardiovascular Risks journal2616-633XБелорусский государственный медицинский университетemcardio-182Research ArticleОбзоры и лекцииReviews and lecturesПатогенез клеточного старения: полиморфизм генов и активность ренин-ангиотензин-альдостероновой системыThe pathogenesis of cell aging: gene polymorphism and renin-angiotensin-aldosterone system activityПавловаО. С.PavlovaO. S.КоробкоИ. Ю.KorobkoI. Yu.ЛивенцеваМ. М.LiventsevaM. M.БарбукО. А.BarbukO. A.РусскихИ. И.RusskikhI. I.КолядкоМ. Г.KaliadkaM. G.ГарькаваяА. М.GorkavayaA. M.ОгурцоваС. Э.OgurtsovaS. E.Республиканский научно-практический центр «Кардиология»Republican Scientific and Practical Center of CardiologyИнститут биоорганической химии Национальной Академии наук БеларусиInstitute of Bioorganic Chemistry20203010202541898–903Copyright © Павлова О.С., Коробко И.Ю., Ливенцева М.М., Барбук О.А., Русских И.И., Колядко М.Г., Гарькавая А.М., Огурцова С.Э., 20252025Павлова О.С., Коробко И.Ю., Ливенцева М.М., Барбук О.А., Русских И.И., Колядко М.Г., Гарькавая А.М., Огурцова С.Э.Pavlova O.S., Korobko I.Y., Liventseva M.M., Barbuk O.A., Russkikh I.I., Kaliadka M.G., Gorkavaya A.M., Ogurtsova S.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://emcardio.bsmu.by/jour/article/view/182

Цель исследования заключалась в определении взаимосвязи генетического полиморфизма и компонентов ренин-ангиотензин-альдостероновой системы (РААС) с относительной длиной теломер (ДЛТ) лейкоцитов у лиц с нормальным или оптимальным артериальным давлением (АД).

The aim of the study was to determine the correlation of genetic polymorphism and renin-angiotensin-aldosterone system (RAAS) components with the relative leukocyte telomere length (TL) in individuals with normal or optimal blood pressure.

длина теломер лейкоцитовренин-ангиотензин-альдостероновая системаангиотензин IIгенетический полиморфизмген ангиотензиногенаген ренинаleukocyte telomere lengthrenin-angiotensin-aldosterone systemangiotensin IIgenetic polymorphismangiotensinogen generenin geneReferencesYeh J.K., Wang C.Y. Telomeres and Telomerase in Cardiovascular Disease. Genes (Basel), 2016, vol. 7, no. 9, pp. 7-58.Yeh J.K., Wang C.Y. Telomeres and Telomerase in Cardiovascular Disease. Genes (Basel), 2016, vol. 7, no. 9, pp. 7-58.Madrid A.S., Rode L., Nordestgaard B.G., Bojesen S.E. Short telomere length and ischemic heart disease: Observational and genetic studies in 290 022 individuals. Clin. Chem, 2016, vol. 62, no. 8, pp. 1140-1149. doi: 10.1373/clinchem.2016.258566.Madrid A.S., Rode L., Nordestgaard B.G., Bojesen S.E. Short telomere length and ischemic heart disease: Observational and genetic studies in 290 022 individuals. Clin. Chem, 2016, vol. 62, no. 8, pp. 1140-1149. doi: 10.1373/clinchem.2016.258566.Xu C., Wang Z., Su X., Da M., Yang Z., Duan W., Mo X. Association between leucocyte telomere length and cardiovascular disease in a large general population in the United States. Sci Rep, 2020, vol.10, no.1, 80p. doi: 10.1038/s41598-019-57050-1.Xu C., Wang Z., Su X., Da M., Yang Z., Duan W., Mo X. Association between leucocyte telomere length and cardiovascular disease in a large general population in the United States. Sci Rep, 2020, vol.10, no.1, 80p. doi: 10.1038/s41598-019-57050-1.Tian Y., Wang S., Jiao F., Kong Q., Liu C., Wu Y. Telomere Length: A Potential Biomarker for the Risk and Prognosis of Stroke. Front Neurol, 2019, no. 10, pp. 624. doi: 10.3389/fneur.2019.00624.Tian Y., Wang S., Jiao F., Kong Q., Liu C., Wu Y. Telomere Length: A Potential Biomarker for the Risk and Prognosis of Stroke. Front Neurol, 2019, no. 10, pp. 624. doi: 10.3389/fneur.2019.00624.Muñoz-Durango N., Fuentes C.A., Castillo A.E., Luis Martín González-Gómez L.M., Vecchiola A., Fardella C.E., Kalergis A.M. Role of the Renin-Angiotensin-Aldosterone System beyond Blood Pressure Regulation: Molecular and Cellular Mechanisms Involved in End-Organ Damage during Arterial Hypertension. Int J Mol Sci, 2016, vol. 17, no. 7, pp. 797. doi: 10.3390/ijms17070797.Muñoz-Durango N., Fuentes C.A., Castillo A.E., Luis Martín González-Gómez L.M., Vecchiola A., Fardella C.E., Kalergis A.M. Role of the Renin-Angiotensin-Aldosterone System beyond Blood Pressure Regulation: Molecular and Cellular Mechanisms Involved in End-Organ Damage during Arterial Hypertension. Int J Mol Sci, 2016, vol. 17, no. 7, pp. 797. doi: 10.3390/ijms17070797.Vasan R.S., Demissie S., Kimura M., Cupples L.A., White C, Gardner JP, Cao X, Levy D, Benjamin EJ, Aviv A. Association of leukocyte telomere length with echocardiographic left ventricular mass: the Framingham heart study. Circulation, 2009, vol. 120, no. 13, pp. 1195-1202.Vasan R.S., Demissie S., Kimura M., Cupples L.A., White C, Gardner JP, Cao X, Levy D, Benjamin EJ, Aviv A. Association of leukocyte telomere length with echocardiographic left ventricular mass: the Framingham heart study. Circulation, 2009, vol. 120, no. 13, pp. 1195-1202.Benetos A., Gardner J.P., Kimura M., Labat C., Nzietchueng R., Dousset B., Zannad F., Lacolley P., Aviv A. Aldosterone and telomere length in white blood cells. J Gerontol A Biol Sci Med Sci, 2005, vol. 60, no. 12, pp. 1593-1596.Benetos A., Gardner J.P., Kimura M., Labat C., Nzietchueng R., Dousset B., Zannad F., Lacolley P., Aviv A. Aldosterone and telomere length in white blood cells. J Gerontol A Biol Sci Med Sci, 2005, vol. 60, no. 12, pp. 1593-1596.Nilsson P.M., Tufvesson H., Leosdottir M., Melander O. Telomeres and cardiovascular disease risk: an update 2013. Transl Res, 2013, vol. 162, no. 6, pp. 371-380. doi: 10.1016/j.trsl.2013.05.004.Nilsson P.M., Tufvesson H., Leosdottir M., Melander O. Telomeres and cardiovascular disease risk: an update 2013. Transl Res, 2013, vol. 162, no. 6, pp. 371-380. doi: 10.1016/j.trsl.2013.05.004.Fyhrquist F., Silventoinen K., Saijonmaa O., Kontula K., Devereux R.B., de Faire U., Os I., Dahlöf B. Telomere length and cardiovascular risk in hypertensive patients with left ventricular hypertrophy: the LIFE study. J Hum Hypertens, 2011, vol. 25, no. 12, pp. 711-718. doi: 10.1038/jhh.2011.57.Fyhrquist F., Silventoinen K., Saijonmaa O., Kontula K., Devereux R.B., de Faire U., Os I., Dahlöf B. Telomere length and cardiovascular risk in hypertensive patients with left ventricular hypertrophy: the LIFE study. J Hum Hypertens, 2011, vol. 25, no. 12, pp. 711-718. doi: 10.1038/jhh.2011.57.Jeunemaitre X., Soubrier F., Kotelevtsev Y.V., Williams C.S., Charru A.S, Hunt C., Hopkins P.N., Williams R.R., Lalouel J.M. Molecular basis of human hypertension: role of angiotensinogen. Cell, 1992, vol. 71, no. 1, pp. 169-180.Jeunemaitre X., Soubrier F., Kotelevtsev Y.V., Williams C.S., Charru A.S, Hunt C., Hopkins P.N., Williams R.R., Lalouel J.M. Molecular basis of human hypertension: role of angiotensinogen. Cell, 1992, vol. 71, no. 1, pp. 169-180.Sethi A.A., Nordestgaard B.G., Tybjaerg-Hansen A. Angiotensinogen gene polymorphism, plasma angiotensinogen, and risk of hypertension and ischemic heart disease: a meta-analysis. Arterioscler Thromb Vasc Biol, 2003, vol. 23, no. 7, pp. 1269-1275. doi: 10.1161/01.ATV.0000079007.40884.5C.Sethi A.A., Nordestgaard B.G., Tybjaerg-Hansen A. Angiotensinogen gene polymorphism, plasma angiotensinogen, and risk of hypertension and ischemic heart disease: a meta-analysis. Arterioscler Thromb Vasc Biol, 2003, vol. 23, no. 7, pp. 1269-1275. doi: 10.1161/01.ATV.0000079007.40884.5C.Konoshita T. Do genetic variants of the Renin-Angiotensin system predict blood pressure response to Renin-Angiotensin system-blocking drugs? A systematic review of pharmacogenomics in the Renin-Angiotensin system. Curr Hypertens Rep, 2011, vol. 13, no. 5, pp. 356-361.Konoshita T. Do genetic variants of the Renin-Angiotensin system predict blood pressure response to Renin-Angiotensin system-blocking drugs? A systematic review of pharmacogenomics in the Renin-Angiotensin system. Curr Hypertens Rep, 2011, vol. 13, no. 5, pp. 356-361.Pychtina V.S., Strazhesko I.D., Agal’zov M.V., Tkacheva O.N. Penin-angiotenzin-al’dosteronovaya sistema i replikativnoe kletochnoe starenie: ich vzaimodeystvie v chode stareniya sosudov [Renin-angiotensin-aldosterone system and replicative cellular senescence: their interaction during the vascular ageing]. Razional’naya Farmakoterapiya v Kardiologii, 2014, vol. 10, no. 3, pp. 312-316. (in Russian).Pychtina V.S., Strazhesko I.D., Agal’zov M.V., Tkacheva O.N. Penin-angiotenzin-al’dosteronovaya sistema i replikativnoe kletochnoe starenie: ich vzaimodeystvie v chode stareniya sosudov [Renin-angiotensin-aldosterone system and replicative cellular senescence: their interaction during the vascular ageing]. Razional’naya Farmakoterapiya v Kardiologii, 2014, vol. 10, no. 3, pp. 312-316. (in Russian).

The authors declare that there are no conflicts of interest present.