emcardioНеотложная кардиология и кардиоваскулярные рискиEmergency Cardiology and Cardiovascular Risks journal2616-633XБелорусский государственный медицинский университетemcardio-175Research ArticleКлинический случайБолезнь Стилла взрослых у беременной, осложненная синдромом активации макрофаговAdult-onset Still’s disease in pregnancy complicated by macrophage activation syndromeАртишевскаяН. И.ArtishevskaiaN. I.РаевневаТ. Г.RayeunevaT. G.АлексейчикС. Е.AliakseitshikS. E.МихневичЭ. А.MikhnevichE. A.МалютаЕ. М.MalyutaA. M.Белорусский государственный медицинский университетBelarusian State Medical UniversityУчреждение здравоохранения «3 городская клиническая больница»The 3rdCity Clinical Hospital20203010202541877–881Copyright © Артишевская Н.И., Раевнева Т.Г., Алексейчик С.Е., Михневич Э.А., Малюта Е.М., 20252025Артишевская Н.И., Раевнева Т.Г., Алексейчик С.Е., Михневич Э.А., Малюта Е.М.Artishevskaia N.I., Rayeuneva T.G., Aliakseitshik S.E., Mikhnevich E.A., Malyuta A.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://emcardio.bsmu.by/jour/article/view/175

Болезнь Стилла взрослых – редкое полигенное аутовоспалительное заболевание. Классические клинические проявления включают лихорадку, артрит и кожные высыпания. В предшествующее десятилетие уточнены некоторые патофизиологические механизмы заболевания, предложены чувствительные и специфичные диагностические критерии. В то же время диагноз болезни Стилла взрослых остается диагнозом исключения. А течение заболевания может быть как относительно благоприятным, так и инвалидизирующим. Лечение болезни Стилла взрослых на современном этапе базируется на применении глюкокортикоидов, иммуносупрессивной терапии и моноклональных антител.

Adult-onset Still’s disease is a rare polygenicautoinflammatory disease characterized by the classic triad of persistent high spiking fevers, joint pain (arthritis), and a distinctive salmon-colored bumpy rash. In the past decade, some pathophysiological mechanisms of the disease have been clarified and some sensitive and specific diagnostic criteria have been suggested. The disease is considered a diagnosis of exclusion. The course of the disease can be either relatively favorable or severe and disabling. Treatment is based on the use of glucocorticoids, immunosuppressive therapy and monoclonal antibodies. In the early 21 st century, descriptions of isolated cases and small series of adult-onset Still’s disease in pregnancy appeared in literature

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The authors declare that there are no conflicts of interest present.