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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">emcardio</journal-id><journal-title-group><journal-title xml:lang="ru">Неотложная кардиология и кардиоваскулярные риски</journal-title><trans-title-group xml:lang="en"><trans-title>Emergency Cardiology and Cardiovascular Risks journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2616-633X</issn><publisher><publisher-name>Белорусский государственный медицинский университет</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.51922/2616-633X.2021.5.2.1202</article-id><article-id custom-type="elpub" pub-id-type="custom">emcardio-136</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Клинический случай</subject></subj-group></article-categories><title-group><article-title>Некоторые аспекты клинико-лабораторных показателей у новорожденных от матерей с коронавирусной инфекцией, вызванной SARS-CoV-2 (COVID-19), инфицированных в различные сроки перинатального периода</article-title><trans-title-group xml:lang="en"><trans-title>Some aspects of clinical and laboratory parameters in newborns from mothers with coronavirus infection SARS-CoV-2 (COVID-19), infected at different times of perinatal period</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Логинова</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Loginova</surname><given-names>I.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Устинович</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Ustinovich</surname><given-names>A.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Альферович</surname><given-names>Е. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Alferovich</surname><given-names>E.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Паюк</surname><given-names>И. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Payuk</surname><given-names>I.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шнитко</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Shnitko</surname><given-names>V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Белорусский государственный медицинский университет</institution></aff><aff xml:lang="en"><institution>Belarusian State Medical University</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Учреждение здравоохранения «3-я городская детская клиническая больница»</institution></aff><aff xml:lang="en"><institution>Health care institution “3rd City Children’s Clinical Hospital”</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>22</day><month>10</month><year>2025</year></pub-date><volume>5</volume><issue>1</issue><fpage>1202</fpage><lpage>1209</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Логинова И.А., Устинович А.А., Альферович Е.Н., Паюк И.И., Шнитко В.В., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Логинова И.А., Устинович А.А., Альферович Е.Н., Паюк И.И., Шнитко В.В.</copyright-holder><copyright-holder xml:lang="en">Loginova I., Ustinovich A., Alferovich E., Payuk I., Shnitko V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://emcardio.bsmu.by/jour/article/view/136">https://emcardio.bsmu.by/jour/article/view/136</self-uri><abstract><p>Проблема коронавирусной инфекции волнует весь мир с 2019 года. При этом неясными остаются вопросы инфицирования новорожденных детей, обсуждается вопрос вертикальной передачи вируса от матери к ребенку. Целью нашего исследования было изучить особенности периода постнатальной адаптации новорожденных, рожденных от матерей с коронавирусной инфекцией, вызванной SARS-CoV-2 (COVID-19), с учетом сроков ее возникновения. Нами проведен анализ особенностей течения неонатального периода у детей от матерей с подтвержденной инфекцией COVID-19 (ПЦР РНК коронавируса SARS-CoV-2), выявленной у них либо во время беременности, либо в послеродовом периоде. При обследовании детей использовались клинический, лабораторный, биохимический методы исследования. Выявлено, что у детей, чьи матери заболели коронавирусной инфекцией COVID-19 непосредственно перед родами, отмечается отягощенное течение неонатального периода по сравнению с детьми от матерей, переболевших в середине беременности, а проявления внутриутробной инфекции и постгипоксического синдрома были более выраженными. Лабораторные методы исследования у новорожденных от матерей, заболевших накануне родов, свидетельствовали в пользу острого вирусного воспаления</p></abstract><trans-abstract xml:lang="en"><p>The problem of coronavirus infection has been the world’s concern since 2019. At the same time, the issues of infection of newborn children remain unclear, the issue of vertical transmission of the virus from mother to child is being discussed. The aim of our study was to study the features of the period of postnatal adaptation of newborns born to mothers with coronavirus infection SARS-CoV-2 (COVID-19), taking into account the time of infection occurrence. We analyzed the features of the neonatal course in children from the mothers with confirmed Covid-19 infection (PCR RNA of SARS-Cov 2) revealed in the mothers either during pregnancy or in the postpartum period. When examining children, we used clinical, laboratory, and biochemical research methods. It was found that children whose mothers contracted coronavirus infection COVID-19 immediately before childbirth had an aggravated course of the neonatal period compared with children from mothers who had recovered in the middle of pregnancy, and the manifestations of infection and post-hypoxic syndrome were more pronounced in the former. Laboratory investigations proved that newborns from the mothers who fell ill shortly before childbirth had acute viral inflammation.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>коронавирусная инфекция</kwd><kwd>вызванная SARS-CoV-2 (COVID-19)</kwd><kwd>новорожденные дети</kwd><kwd>ферритин</kwd><kwd>лактатдегидрогеназа</kwd><kwd>церебральная депрессия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>coronavirus infection SARS-CoV-2 (COVID-19)</kwd><kwd>newborns</kwd><kwd>ferritin</kwd><kwd>lactate dehydrogenase</kwd><kwd>cerebral depression</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Namazova-Baranova L.S. Koronavirusnaya infekziya (Covid-19) u detey (sostoyanie na aprel 2020) [Coronaviral infection (COVID-19) in children (situation on April 2020)]. Pediatricheskaya farmakologiya, 2020, vol. 17, no. 2, pp. 85-94. (in Russian).</mixed-citation><mixed-citation xml:lang="en">Namazova-Baranova L.S. Koronavirusnaya infekziya (Covid-19) u detey (sostoyanie na aprel 2020) [Coronaviral infection (COVID-19) in children (situation on April 2020)]. Pediatricheskaya farmakologiya, 2020, vol. 17, no. 2, pp. 85-94. (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Molloy E.J., Bearer C.F. COVID-19 inchildrenandalteredinflammatoryresponses. Pediatr Res, 2020, vol. 88, no. 3, pp. 340-341. doi: 10.1038/s41390-0200881-y.</mixed-citation><mixed-citation xml:lang="en">Molloy E.J., Bearer C.F. COVID-19 inchildrenandalteredinflammatoryresponses. Pediatr Res, 2020, vol. 88, no. 3, pp. 340-341. doi: 10.1038/s41390-0200881-y.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Cristiani L., Mancino E., Matera L., Nenna R., Pierangeli A., Scagnolari C., Midulla F. Will children reveal their secret? The coronavirus dilemma. Eur Respir J, 2020, vol. 55, no. 4, pp. 2000749. doi: 10.1183/13993003.00749-2020.</mixed-citation><mixed-citation xml:lang="en">Cristiani L., Mancino E., Matera L., Nenna R., Pierangeli A., Scagnolari C., Midulla F. Will children reveal their secret? The coronavirus dilemma. Eur Respir J, 2020, vol. 55, no. 4, pp. 2000749. doi: 10.1183/13993003.00749-2020.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Zeng H., Хu С., Fan J., Tang Y., Deng Q., Zhang W., Long X. Antibodies in infantsвorn to mothers with COVID-19 pneumonia. JAMA, 2020, vol. 323, no. 18, pp. 1848-1849. doi: 10.1001/jama.2020.4861.</mixed-citation><mixed-citation xml:lang="en">Zeng H., Хu С., Fan J., Tang Y., Deng Q., Zhang W., Long X. Antibodies in infantsвorn to mothers with COVID-19 pneumonia. JAMA, 2020, vol. 323, no. 18, pp. 1848-1849. doi: 10.1001/jama.2020.4861.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Dong L., Tian J., He S., Zhu C., Wang J., Liu C., Yang J. Possible vertical transmission of SARS-CoV-2 from an infected mother to her newborn. JAMA, 2020, vol. 323, no. 18, pp. 1846-1848. doi: 10.1001/jama.2020.4621.</mixed-citation><mixed-citation xml:lang="en">Dong L., Tian J., He S., Zhu C., Wang J., Liu C., Yang J. Possible vertical transmission of SARS-CoV-2 from an infected mother to her newborn. JAMA, 2020, vol. 323, no. 18, pp. 1846-1848. doi: 10.1001/jama.2020.4621.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Wang W., Xu Y., Gao R., Lu R., Han K., Wu G., Tan W. Detection of SARS-CoV-2 in different types of clinical specimens. JAMA, 2020, vol. 323, no. 18, pp. 1843-1844. doi: 10.1001/jama.2020.3786.</mixed-citation><mixed-citation xml:lang="en">Wang W., Xu Y., Gao R., Lu R., Han K., Wu G., Tan W. Detection of SARS-CoV-2 in different types of clinical specimens. JAMA, 2020, vol. 323, no. 18, pp. 1843-1844. doi: 10.1001/jama.2020.3786.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Chen H., Guo J., Wang C., Luo F., Yu X., Zhang W., Li J., Zhao D., Xu D., Gong Q., Liao J., Yang H., Hou W., Zhang Y. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet, 2020, vol. 395, no. 10226, pp. 809-815. doi: 10.1016/S0140-6736(20)30360-3.</mixed-citation><mixed-citation xml:lang="en">Chen H., Guo J., Wang C., Luo F., Yu X., Zhang W., Li J., Zhao D., Xu D., Gong Q., Liao J., Yang H., Hou W., Zhang Y. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet, 2020, vol. 395, no. 10226, pp. 809-815. doi: 10.1016/S0140-6736(20)30360-3.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">World Health Organization. Coronavirus disease (COVID-2019) situation reports [electronic resource]. Available at: https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports.</mixed-citation><mixed-citation xml:lang="en">World Health Organization. Coronavirus disease (COVID-2019) situation reports [electronic resource]. Available at: https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Zeng L., Xia S., Yuan W., Yan K., Xiao F., Shao J., Zhou W. Neonatal early-onset infection with SARS-CoV-2 in 33 neonatesвоrn to mothers with COVID-19 in Wuhan, China. JAMA Pediatr, 2020, vol. 174, no. 7, pp. 722-725. doi: 10.1001/jamapediatrics.2020.0878</mixed-citation><mixed-citation xml:lang="en">Zeng L., Xia S., Yuan W., Yan K., Xiao F., Shao J., Zhou W. Neonatal early-onset infection with SARS-CoV-2 in 33 neonatesвоrn to mothers with COVID-19 in Wuhan, China. JAMA Pediatr, 2020, vol. 174, no. 7, pp. 722-725. doi: 10.1001/jamapediatrics.2020.0878</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
