emcardioНеотложная кардиология и кардиоваскулярные рискиEmergency Cardiology and Cardiovascular Risks journal2616-633XБелорусский государственный медицинский университет10.51922/2616-633X.2025.9.1.2524emcardio-131Research ArticleОбзоры и лекцииReviews and lecturesСиндром старческой астении как предиктор неблагоприятного прогноза для пациентов с сердечно-сосудистыми заболеваниямиSenile asthenia (frailty) syndrome as a predictor of poor prognosis for patients with cardiovascular diseasesПатеюкИ. В.PatsiayukI. V.

Минск

Minsk

ЖилевичЛ. А.ZhylevichL. A.

Минск

Minsk

lzhylevich@gmail.comЛобашоваВ. Л.LobashovaV. L.

Минск

Minsk

МуринаА. В.MurinaA. V.

Минск

Minsk

Учреждение образования «Белорусский государственный медицинский университет»Belarusian State Medical University2025110920259125242530Copyright © Патеюк И.В., Жилевич Л.А., Лобашова В.Л., Мурина А.В., 20252025Патеюк И.В., Жилевич Л.А., Лобашова В.Л., Мурина А.В.Patsiayuk I.V., Zhylevich L.A., Lobashova V.L., Murina A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://emcardio.bsmu.by/jour/article/view/131

Демографические тенденции в Республике Беларусь характеризуются как постарение населения и ведут к росту числа лиц с полиморбидной патологией, где ведущую роль играют заболевания сердечно-сосудистой системы.

Высокая распространенность кардиоваскулярной патологии и ее частая патогенетическая взаимосвязь с различными коморбидными заболеваниями и состояниями приводят к увеличению числа трудных для ведения в практике врача пациентов с разнообразной сочетанной патологией.

Основными проблемами при ведении данной категории пациентов являются: увеличение продолжительности периода госпитализации, сложность подбора лекарственной терапии и проведения реабилитационных мероприятий в полном объеме из-за наличия кардиоваскулярного риска, увеличение процента нежелательных явлений и/или осложнений на протяжении всего лечения.

Данные заболевания являются факторами риска не только смертности, но и риска развития синдрома старческой астении. Поэтому очень важно оценить характер связи между астенией и сердечно-сосудистыми заболеваниями.

Demographic trends in the Republic of Belarus lead to an increase in the number of people with polymorbid pathology, where cardiovascular diseases play a leading role.

The high prevalence of cardiovascular pathology and its frequent pathogenetic relationship with various comorbid diseases and conditions lead to an increase in the number of patients with various combined pathologies that are difficult to manage in a physician’s practice.

The main problems in the management of this category of patients are: an increase in the duration of hospitalization, the complexity of selecting drug therapy and conducting rehabilitation measures in full due to the presence of cardiovascular risk, an increase in the percentage of adverse events and/or complications throughout the treatment.

These diseases are risk factors not only for mortality, but also for the risk of developing senile asthenia or frailty syndrome. Therefore, it is very important to assess the nature of the relationship between frailty and cardiovascular diseases.

старческая астениягериатрические синдромысердечно-сосудистые заболеванияоценка рискахроническая сердечная недостаточностьартериальная гипертензияsenile astheniafrailtygeriatric syndromescardiovascular diseasesrisk assessmentchronic heart failurearterial hypertensionReferencesKrivoshapova K.E., Galimova N.A., Bazdyrev E.D., Barbarash O.L. Sex differences in frailty manifestations in patients with coronary artery disease. Cardiovascular Therapy and Prevention, 2023, vol. 22(1), pp. 3378. doi: 10.15829/1728-8800-2023-3378. (in Russian).Krivoshapova K.E., Galimova N.A., Bazdyrev E.D., Barbarash O.L. Sex differences in frailty manifestations in patients with coronary artery disease. Cardiovascular Therapy and Prevention, 2023, vol. 22(1), pp. 3378. doi: 10.15829/1728-8800-2023-3378. (in Russian).Tkacheva O.N., Runikhina N.K., Baben I.V. Modern geriatrics for primary healthcare physicians. Med benefit, 2021, no 2, рр. 174. (in Russian).Tkacheva O.N., Runikhina N.K., Baben I.V. Modern geriatrics for primary healthcare physicians. Med benefit, 2021, no 2, рр. 174. (in Russian).Tkacheva O.N., Kotovskaya Yu.V., Ostapenko V.S., Sharashkina N.V Frailty in old age: what does a primary care physician need to know about it? RMJ, 2017, vol. 25(25), pp. 1820–1822. (in Russian).Tkacheva O.N., Kotovskaya Yu.V., Ostapenko V.S., Sharashkina N.V Frailty in old age: what does a primary care physician need to know about it? RMJ, 2017, vol. 25(25), pp. 1820–1822. (in Russian).Rockwood K., Hogan D.B., MacKnight C. Conceptualization and measurement of frailty in elderly people. Drugs and Aging, 2001, vol. 17(4), pp. 295–302. doi: 10.2165/00002512-200017040-00005.Rockwood K., Hogan D.B., MacKnight C. Conceptualization and measurement of frailty in elderly people. Drugs and Aging, 2001, vol. 17(4), pp. 295–302. doi: 10.2165/00002512-200017040-00005.Fried L.P., Tangen C.M., Walston J., et al. Fraity in older adults: evidence for a phenotype. Journals of Gerontology Series A-Biological Sciences and Medical Sciences, 2001, vol. 56(3), M146-56. doi: 10.1093/gerona/56.3.m146.Fried L.P., Tangen C.M., Walston J., et al. Fraity in older adults: evidence for a phenotype. Journals of Gerontology Series A-Biological Sciences and Medical Sciences, 2001, vol. 56(3), M146-56. doi: 10.1093/gerona/56.3.m146.Borkhanova E.G., Almukhametova A.I., Maksudova A.N. Prevalance of nutritional disorders and frailty in predialysis geriartric patients. Nephrology (Saint-Petersburg), 2019, vol. 23(S), pp. 22–23(in Russian).Borkhanova E.G., Almukhametova A.I., Maksudova A.N. Prevalance of nutritional disorders and frailty in predialysis geriartric patients. Nephrology (Saint-Petersburg), 2019, vol. 23(S), pp. 22–23(in Russian).Alonso Salinas G.L., Fernandenz M.S., Izco M.P. et al. Frailty is a shortterm prognostic marker in acute coronary syndrome of elderly patients. Eur Heart J Acute Cardiovasc Care, 2016, vol. 5(5), pp. 434-440. doi: 10.1177/2048872616644909.Alonso Salinas G.L., Fernandenz M.S., Izco M.P. et al. Frailty is a shortterm prognostic marker in acute coronary syndrome of elderly patients. Eur Heart J Acute Cardiovasc Care, 2016, vol. 5(5), pp. 434-440. doi: 10.1177/2048872616644909.Alonso Salinas G.L., Sanmartin M., Izco M.P. et al. The role of frailty in acute coro - nary syndromes in the elderly. Gerontology. 2018, vol. 64(5), pp. 422-429. doi: 10.1159/000488390.Alonso Salinas G.L., Sanmartin M., Izco M.P. et al. The role of frailty in acute coro - nary syndromes in the elderly. Gerontology. 2018, vol. 64(5), pp. 422-429. doi: 10.1159/000488390.Paykova A.S., Bashlacheva Ye.A. Structure of cardiovascular pathology in patients with frailty syndrome. Therapy, 2023, vol. 9(3S;65): 331-332. doi:10.18565/therapy.2023.3suppl.331-332 (in Russian).Paykova A.S., Bashlacheva Ye.A. Structure of cardiovascular pathology in patients with frailty syndrome. Therapy, 2023, vol. 9(3S;65): 331-332. doi:10.18565/therapy.2023.3suppl.331-332 (in Russian).Aydumova O.Yu., Shchukin Yu.V., Piskunov M.V. Effect of senile asthenia syndrome on cardiovascular mortality within 12 months in patients over 70 years of age with myocardial infarction. Russian Journal of Cardiology, 2023, vol. 28(2S), pp. 38–46. (in Russian).Aydumova O.Yu., Shchukin Yu.V., Piskunov M.V. Effect of senile asthenia syndrome on cardiovascular mortality within 12 months in patients over 70 years of age with myocardial infarction. Russian Journal of Cardiology, 2023, vol. 28(2S), pp. 38–46. (in Russian).Vasenina E.E., Gankina O.A., Levin O.S. Stress, asthenia and cognitive disorders. S.S.Korsakov Journal of Neurology and Psychiatry, 2022, vol. 122(5), pp. 23–29. doi:10.17116/jnevro202212205123. (in Russian).Vasenina E.E., Gankina O.A., Levin O.S. Stress, asthenia and cognitive disorders. S.S.Korsakov Journal of Neurology and Psychiatry, 2022, vol. 122(5), pp. 23–29. doi:10.17116/jnevro202212205123. (in Russian).Artemyeva O.V.1, Grechenko V.V.1, Gromova T.V.1, Gankovskaya L.V. Frailty: a controversial role of inflammaging. Immunologiya, 2022, vol. 43(6), pp. 746–756. doi:10.33029/0206-4952-2022-43-6-746-756. (in Russian).Artemyeva O.V.1, Grechenko V.V.1, Gromova T.V.1, Gankovskaya L.V. Frailty: a controversial role of inflammaging. Immunologiya, 2022, vol. 43(6), pp. 746–756. doi:10.33029/0206-4952-2022-43-6-746-756. (in Russian).Safronenko V.A., Chesnikova A.I. Peculiarities of the daily profile of arterial pressure and vascular stiffness in arterial hypertension and chronic heart failure patients with senile asthenia syndrome. Therapy, 2025, vol. 11(2), pp. 8–16. doi: 10.18565/therapy.2025.2.8-16. (in Russian).Safronenko V.A., Chesnikova A.I. Peculiarities of the daily profile of arterial pressure and vascular stiffness in arterial hypertension and chronic heart failure patients with senile asthenia syndrome. Therapy, 2025, vol. 11(2), pp. 8–16. doi: 10.18565/therapy.2025.2.8-16. (in Russian).Tkacheva O.N., Runikhina N.K., Kotovskaya Yu.V. et al. Arterial hypertension management in patients aged older than 80 years and patients with the senile asthenia. Cardiovascular Therapy and Prevention, 2017, vol. 16(1), pp. 8–21. doi: 10.15829/1728-8800-2017-1-8-21. (in Russian).Tkacheva O.N., Runikhina N.K., Kotovskaya Yu.V. et al. Arterial hypertension management in patients aged older than 80 years and patients with the senile asthenia. Cardiovascular Therapy and Prevention, 2017, vol. 16(1), pp. 8–21. doi: 10.15829/1728-8800-2017-1-8-21. (in Russian).Jiménez-Méndez C., Díez-Villanueva P., Bonanad C. et al. Frailt y and prognosis of older patients with chronic heart failure. Revista Espanola de Cardiologia, 2022, vol. 75(12), pp. 1011–1019. doi: 10.1016/j.rec.2022.04.016.Jiménez-Méndez C., Díez-Villanueva P., Bonanad C. et al. Frailt y and prognosis of older patients with chronic heart failure. Revista Espanola de Cardiologia, 2022, vol. 75(12), pp. 1011–1019. doi: 10.1016/j.rec.2022.04.016.Safronenko V.A., Chesnikova A.I., Safronenko A.V. Cognitive impairments in patients with arterial hypertension and senile asthenia syndrome depending on the presence of chronic heart failure. Cardiovascular Therapy and Prevention. 2023, vol. 22(S6), pp. 12. (in Russian).Safronenko V.A., Chesnikova A.I., Safronenko A.V. Cognitive impairments in patients with arterial hypertension and senile asthenia syndrome depending on the presence of chronic heart failure. Cardiovascular Therapy and Prevention. 2023, vol. 22(S6), pp. 12. (in Russian).Dodson J.A., Chaudhry S.I. Geriatric Conditions in Heart Failure. Current Cardiovascular Risk Reports, 2012, vol. 6(5), pp. 404–410. doi: 10.1007/s12170-012-0259-8.Dodson J.A., Chaudhry S.I. Geriatric Conditions in Heart Failure. Current Cardiovascular Risk Reports, 2012, vol. 6(5), pp. 404–410. doi: 10.1007/s12170-012-0259-8.Jylhävä J., Nevalainen T., Marttila S. et al. Characterization of the role of distinct plasma cell-free DNA species in age-associated inflammation and frailty. Aging Cell, 2013, vol. 12(3), pp. 388–397. doi: 10.1111/acel.12058.Jylhävä J., Nevalainen T., Marttila S. et al. Characterization of the role of distinct plasma cell-free DNA species in age-associated inflammation and frailty. Aging Cell, 2013, vol. 12(3), pp. 388–397. doi: 10.1111/acel.12058.Kotovskaya Yu.V., Rozanov A.V., Kurashev D.Kh., Tkacheva O.N. Heart failure and senile asthenia syndrome. Medical Council, 2018, vol. 16, pp. 72–79. doi: 10.21518/2079-701X-2018-16-72-79. (in Russian).Kotovskaya Yu.V., Rozanov A.V., Kurashev D.Kh., Tkacheva O.N. Heart failure and senile asthenia syndrome. Medical Council, 2018, vol. 16, pp. 72–79. doi: 10.21518/2079-701X-2018-16-72-79. (in Russian).Agarkov N.M., Makkonen K.F., Titov A.A., Mitikhina M.S., Kolpina L.V. Changes in the lipidogram and hemostasis system in elderly patients with myocardial infarction, hypertension depending on the severity of senile asthenia syndrome. Arterialnaya gipertenziya, 2022, vol. 28(3), pp. 280–288. doi: 10.18705/1607-419X-2022-28-3-280-288. (in Russian).Agarkov N.M., Makkonen K.F., Titov A.A., Mitikhina M.S., Kolpina L.V. Changes in the lipidogram and hemostasis system in elderly patients with myocardial infarction, hypertension depending on the severity of senile asthenia syndrome. Arterialnaya gipertenziya, 2022, vol. 28(3), pp. 280–288. doi: 10.18705/1607-419X-2022-28-3-280-288. (in Russian).Krivoshapova K.E., Vegner E.A., Barbarash O.L. Frailty syndrome as an independent predictor of adverse prognosis in patients with chronic heart failure. Kardio logiia, 2022, vol. 62(3), pp. 89–96. doi: 10.18087/cardio.2022.3.n1206. (in Russian).Krivoshapova K.E., Vegner E.A., Barbarash O.L. Frailty syndrome as an independent predictor of adverse prognosis in patients with chronic heart failure. Kardio logiia, 2022, vol. 62(3), pp. 89–96. doi: 10.18087/cardio.2022.3.n1206. (in Russian).Crea F. The Atlas of cardiovascular disease in Europe and focus on frailty and cardiovascular risk. Europen Heart Journal, 2022, vol. 43(8), pp. 703–705. doi: 10.1093/eurheartj/ehac066.Crea F. The Atlas of cardiovascular disease in Europe and focus on frailty and cardiovascular risk. Europen Heart Journal, 2022, vol. 43(8), pp. 703–705. doi: 10.1093/eurheartj/ehac066.

The authors declare that there are no conflicts of interest present.