А.И. Чернявина, Н.А. Козиолова
Пермский Государственный Медицинский Университет им. акад. Е.А. Вагнера Минздрава России, г. Пермь
Цель исследования: выявить взаимосвязь гипертрофии левого желудочка (ГЛЖ) с формированием ранней ренальной дисфункции у больных неосложненной ГБ без ХБП.
ключевые слова: артериальная гипертензия, гипертрофия левого желудочка, нарушение фильтрационной функции почек, цистатин С

для цитирования: А.И. Чернявина, Н.А. Козиолова. Взаимосвязь гипертрофии левого желудочка с нарушениями фильтрационной и тубулоинтерстициальной функций почек у пациентов с гипертонической болезнью. Неотложная кардиология и кардиоваскулярные риски, 2020, Т. 4, № 1, С. 861–866. Взаимосвязь структурных изменений сердца с развитием ранних нарушений функций почек у больных с неосложненной гипертонической болезнью (ГБ) без хронической болезни почек (ХБП) остается открытым.

Correlation of left ventricular hypertrophy with impaired filtration and tubulointerstitial kidney function in patients with hypertension
A.I. Chernyavina, N.A. Koziolova
Aim: to identify the correlation of left ventricular hypertrophy (LVH) with the development of early renal dysfunction in patients with uncomplicated HT without CKD.
keywords: arterial hypertension, left ventricular hypertrophy, impaired renal filtration function, cystatin C

for references: A.I. Chernyavina, N.A. Koziolova. Correlation of left ventricular hypertrophy with impaired filtration and tubulointerstitial kidney function in patients with hypertension. Neotlozhnaya kardiologiya i kardiovaskulyarnye riski [Emergency cardiology and cardiovascular risks], 2020, vol. 4, no. 1, pp. 861–866

1. Forouzanfar M.H., Liu P., Roth G.A., Ng M., Biryukov S., Marczak L., Alexander L., Estep K., Abate K.H., Akinyemiju T.F., Ali R., Alvis-Guzman N., Azzopardi P., Banerjee A., Bärnighausen T., Basu A., Bekele T. [et al.]. Global burden of hypertension and systolic blood pressure of at least 110 to 115 mm Hg, 1990-2015. JAMA, 2017, vol. 317, no. 2 pp. 165-182. doi: 10.1001/jama.2016.19043.
2. Williams B., Mancia G., Spiering W., Rosei E.A., Azizi M., Burnier M., Clement D.L., Coca A., de Simone G., Dominiczak A., Kahan T. [et al.]. 2018 ESC/ESH Guidelines for the management of arterial hypertension. Eur Heart J., vol. 39, no. 33, pp. 3021-3104. doi: 10.1093/eurheartj/ehy339.
3. Vel’kov V.V. Cistatin S i NGAL - markery’ preklinicheskoy renal’noy disfunkcii i subklinicheskogo ostrogo povrejdeniya pochek [Cystatin C and NGAL are markers of preclinical renal dysfunction and subclinical acute kidney injury]. Laboratornaya slujba, 2015, no. 2, pp. 38-43. doi: 10.17116/labs20154238-43. (in Russian).
4. Rysz J., Gluba-Brzózka A., Franczyk B., Jabłonowski Z., Ciałkowska-Rysz A. Novel Biomarkers in the Diagnosis of Chronic Kidney Disease and the Prediction of Its Outcome. Int J Mol Sci, 2017, vol. 18, no. 8, pp. 1702. doi: 10.3390/ijms18081702.
5. Chernyavina A.I., Koziolova N.A., Mironova S.V. Renovazal’ny’e vzaimootnosheniya u bol’ny’h neoslojnennoy gipertonicheskoy bolezn’yu [Renovalia relationship in patients with uncomplicated hypertension]. Perm. med. jurn, 2019, vol. 36, no. 4, pp. 5-12. doi: 10.17816/pmj3645-12. (in Russian).
6. Nitta K., Iimuro S., Imai E., Matsuo S., Makino H., Akizawa T., Watanabe T., Ohashi Y., Hishida A. Risk factors for increased left ventricular hypertrophy in patients with chronic kidney disease: findings from the CKD-JAC study. Clin Exp Nephrol, 2017, vol. 21, no. 6, pp. 1146. doi.org/10.1007/s10157-018-1624-9.
7. Amoako Y.A., Laryea D.O., Bedu-Addo G., Nkum B.C., Plange-Rhule J. Lef t ventricular hypertrophy among chronic kidney disease patients in Ghana. Pan Afr Med J, 2017, vol. 28, no. 6, pp. 79. doi:10.11604/pamj.2017.28.79.9183.
8. Angeli F., Ambrosio G. Mechanisms of Left Ventricular Hypertrophy in 9. Hypertension: More than Just Blood Pressure. Rev Argent Cardiol, 2015, vol. 83, pp. 5-6. doi.org/10.7775.rac.v83.i1.5771.
10. Thomas R., eds. Chronic Kidney Disease: from Pathophysiology to Clinical Improvements [electronic resource]. Available at: https://www.intechopen.com/books/chronic-kidney-disease-from-pathophysiology-to-clinical-improvements. (accessed 28.03.2020). doi: 10.5772/intechopen.69574.
11. Rangaswami J., Bhalla V., Blair J., Chang T.I., Costa S., Lentine K.L, Lerma E.V, Mezue K., Molitch M., Mullens W., Ronco C., Tang W.H.W., McCullough P.A. Cardiorenal Syndrome: Classification, Pathophysiology, Diagnosis, and Treatment Strategies: A Scientific Statement From the American Heart Association. Circulation, 2019, vol. 139, no. 16, pp. e840-e878. doi.org/10.1161/CIR.0000000000000664.
12. Di Lullo L., Bellasi А., Barbera V., Russo D., Russo L., Di Iorio B., Cozzolino M., Ronco C. Pathophysiology of the cardio-renal syndromes types 1-5: An uptodate. Indian Heart J, 2017, vol. 69, no. 2, pp. 255-265. doi.org/10.1016/j.ihj.2017.01.005.
13. Leibowitz D. Left ventricular hypertrophy and chronic renal insufficiency in the elderly. Cardiorenal Med, 2014, vol. 4, pp. 168-175. doi:10.1159/000366455.
14. Cao С., Hu J-X., Dong Y-F., Zhan R., Li P., Su H., Peng Q., Wu T., Huang X., Sun W.-H., Wu Q.-H., Cheng X.-S.. Association of Endothelial and Mild Renal Dysfunction With the Severity of Left Ventricular Hypertrophy in Hypertensive Patients. Am J Hypertens, 2016, vol. 29, no. 4, pp. 501-508. doi.org/10.1093/ajh/hpv128.
15. Kim I.Y., Kim J.H., Kim M.J., Lee D.W., Hwang C.G., Han M., Rhee H., Song S.H., Seong E.Y., Lee S.B. Plasma neutrophil gelatinase-associated lipocalin is independently associated with lef t ventricular hyper trophy and diastolic dysfunction in patients with chronic kidney disease. PLoS One, 2018, vol. 13, no. 10, pp. e0205848. doi:10.1371/journal.pone.0205848.
Формат файла: pdf (311.19 Кб)