Н.И. Артишевская, Т.Г. Раевнева, С.Е. Алексейчик, Э.А. Михневич, Е.М. Малюта
Белорусский государственный медицинский университет
Болезнь Стилла взрослых – редкое полигенное аутовоспалительное заболевание. Классические клинические проявления включают лихорадку, артрит и кожные высыпания. В предшествующее десятилетие уточнены некоторые патофизиологические механизмы заболевания, предложены чувствительные и специфичные диагностические критерии. В то же время диагноз болезни Стилла взрослых остается диагнозом исключения. А течение заболевания может быть как относительно благоприятным, так и инвалидизирующим. Лечение болезни Стилла взрослых на современном этапе базируется на применении глюкокортикоидов, иммуносупрессивной терапии и моноклональных антител.
ключевые слова: болезнь Стилла взрослых, беременность, синдром активации макрофагов
для цитирования: Н.И. Артишевская, Т.Г. Раевнева, С.Е. Алексейчик, Э.А. Михневич, Е.М. Малюта. Болезнь Стилла взрослых у беременной, осложненная синдромом активации макрофагов. Неотложная кардиология и кардиоваскулярные риски, 2020, Т. 4, № 1, С. 877–881
Adult-onset Still’s disease in pregnancy complicated by macrophage activation syndrome
N.I. Artishevskaia, T.G. Rayeuneva, S.E. Aliakseitshik, E.A. Mikhnevich, A.M. Malyuta
Adult-onset Still’s disease is a rare polygenicautoinflammatory disease characterized by the classic triad of persistent high spiking fevers, joint pain (arthritis), and a distinctive salmon-colored bumpy rash. In the past decade, some pathophysiological mechanisms of the disease have been clarified and some sensitive and specific diagnostic criteria have been suggested. The disease is considered a diagnosis of exclusion. The course of the disease can be either relatively favorable or severe and disabling. Treatment is based on the use of glucocorticoids, immunosuppressive therapy and monoclonal antibodies. In the early 21 st century, descriptions of isolated cases and small series of adult-onset Still’s disease in pregnancy appeared in literature.
keywords: adult-onset Still’s disease, pregnancy, macrophage activation syndrome
for references: N.I. Artishevskaia, T.G. Rayeuneva, S.E. Aliakseitshik, E.A. Mikhnevich, A.M. Malyuta. Adult-onset Still’s disease in pregnancy complicated by macrophage activation syndrome. Neotlozhnaya kardiologiya i kardiovaskulyarnye riski [Emergency cardiology and cardiovascular risks], 2020, vol. 4, no. 1, pp. 877–881
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