Факторы кардиоваскулярного риска у реципиентов трансплантата почки в раннем послеоперационном периоде

М.В. Смолякова, Н.П. Митьковская, О.В. Калачик, Л.В. Картун

УО «Белорусский государственный медицинский университет», ГУ «Минский научно-практический центр хирургии, трансплантологии и гематологии»

В настоящее время трансплантация трупной донорской почки является оптимальным методом почечно-заместительной терапии, улучшающим качество и увеличивающим продолжительность жизни пациентов с хроническими заболеваниями почек. Высокая частота кардиоваскулярной патологии у данной категории пациентов требует поиска факторов риска сердечно-сосудистых нарушений с целью их своевременной коррекции. Цель исследования: определить факторы кардиоваскулярного риска у реципиентов трансплантата почки в раннем послеоперационном периоде.

ключевые слова: факторы кардиоваскулярного риска, трансплантация почки, послеоперационный период

для цитирования: М.В. Смолякова, Н.П. Митьковская, О.В. Калачик, Л.В. Картун. Факторы кардиоваскулярного риска у реципиентов трансплантата почки в раннем послеоперационном периоде. Неотложная кардиология и кардиооваскулярные риски, 2019, Т. 3, № 1, С. 513–518

Cardiovascular risk factors in renal transplant recipients in the early postoperative period

M.V. Smaliakova, N.P. Mitkovskaya, A.V. Kalachik, L.V. Kartun

The kidney transplantation is the optimal method of renal replacement therapy, which improves the quality and prolongs the life span of patients with chronic kidney diseases. A high frequency of cardiovascular pathology in these patients requires the search for cardiovascular risk factors. The aim of the study was to determine the cardiovascular risk factors in renal transplant recipients in the early postoperative period in the dialysis and early postoperative period.

keywords: cardiovascular risk factors, kidney transplantation, postoperative period

for references: M.V. Smaliakova, N.P. Mitkovskaya, A.V. Kalachik, L.V. Kartun. Cardiovascular risk factors in renal transplant recipients in the early postoperative period. Neotlozhnaya kardiologiya i kardioovaskulyarnye riski [Emergency cardiology and cardiovascular risks], 2019, vol. 3, no. 1, pp. 513–518

1. Wheeller D.C., Baigent C. Cardiovascular risk factors in chronic renal failure. In: Loscalzo J. Loscalzo G. eds. Cardiovascular disease in End-stage Renal Failure. Oxford University Press: Oxford, 2000. pp. 2–28.
2. Gregg L.P., Hedayati S.S. Management of Traditional Cardiovascular Risk Factors in CKD: What Are the Data? Am J Kidney Dis, 2018, vol. 71, no. 3, pp. 71–74. doi: 10.1053/j.ajkd.2017.12.007.
3. Morales J.M., Marcén R., del Castillo D., Andres A., Gonzalez-Molina M., Oppenheimer F., Serón D., Gil-Vernet S., Lampreave I., Gainza F.J., Valdés F., Cabello M., Anaya F., Escuin F., Arias M., Pallardó L., Bustamante J. Risk factors for graft loss and mortality after renal transplantation according to recipient age: a prospective multicentre study. Nephrol Dial Transplant, 2012, suppl. 4, pp. iv39–46.
4. Kasiske B., Chakkera H., Roel J. Explained and unexplained ischemic heart disease risk after renal transplantation. J Am Soc Nephrol, 2000, vol. 11, no. 9, pp. 1735–1743.
5. Haririan A., Sillix D.H., Morawski K., El-Amm J.M., Garnick J., Doshi M.D., West M.S., Gruber S.A. Shor t-term experience with early steroid withdrawal in African-American renal transplant recipients. Am J Transplant, 2006, vol. 6, no. 10, pp. 2396–2402.
6. Kasiske B.L., Anjum S., Shah R., Skogen J., Kandaswamy C., Danielson B., O’Shaughnessy E. A., Dahl D.C., Silkensen J.R., Sahadevan M., Snyder J.J. Hypertension after kidney transplantation. Am J Kidney Diseases, 2004, vol. 43, no. 6, pp. 1071–1081.
7. Sato Y., Fujimoto S., Konta T., Iseki K., Moriyama T., Yamagata K., Tsuruya K., Narita I., Kondo M., Kasahara M., Shibagaki Y., Asahi K., Watanabe T. Anemia as a risk factor for all-cause mortality: obscure synergic effect of chronic kidney disease. Clin Exp Nephrol, 2018, vol. 22, no. 2, pp. 388–394. doi: 10.1007/s10157-017-1468-8.
8. Kalantzi M., Kalliakmani P., Papachristou E., Papasotiriou M., Savvidaki E., Zavvos V., Karavias D., Goumenos D.S., Vlachojannis J.G. Parameters influencing blood erythropoietin levels of renal transplant recipients during the early post-transplantation period. Transplant Proc, 2014, vol. 4 6, no. 9, pp. 3179–3182.
9. Freiberg M., Chiurchiu C., Capra R., Eckhardt A., De La Fuente J., Douthat W., De Arteaga J., Massari P.U. Associirovanny’e faktory’ i klinicheskie posledstviya pochechnoy anemii posle transplantacii [Associated factors and clinical implications of post transplant renal anemia]. Medicina, 2013, vol. 73, no. 2, pp. 136–140. (in Russian).
10. Vanrenterghem I. Anemia after kidney transplantation. Transplantation, 2009, vol. 87, no. 9, pp. 1265–1267.
11. Meléndez G.C., McLarty J.L., Levick S.P., Du Y., Janicki J.S., Brower G.L. Interleukin 6 mediates myocardial fibrosis, concentric hypertrophy, and diastolic dysfunction in rats. Hypertension, 2010, vol. 56, no. 2, pp. 225–231.
12. Pchelin I.Ju., Shishkin A.N., Lapteva O.A. Rol’ sistemnogo i lokal’nogo vospalenija v razvitii diabeticheskoj nefropatii [The role of systemic and local inflammation in the development of diabetic nephropathy]. Nefrologija, 2011, vol. 15, no. 4, pp. 21–26. (in Russian).
13. Danesh J., Kaptoge S., Mann A.G., Sarwar N., Wood A., Angleman S.B., Wensley F., Higgins J.P., Lennon L., Eiriksdottir G., Rumley A., Whincup P.H., Lowe G.D., Gudnason V. Long-term interleukin-6 levels and subsequent risk of coronary heart disease: Two new prospective studies and a systematic review. PLoS Medicine, 2008, vol. 5, no. 4, pp. 78.
14. Paydas S., Karaer R., Centiner S. Hypervolemia and high tumor necrosis factor - α: An interesting finding during the six months’ posttransplant period in kidney transplant recipients with good renal function. Saudi J Kidney Dis Transpl, 2018, vol. 29, no. 4, pp. 889–892.
15. Jhee J.H., Park J., Kim H., Kee Y.K., Park J.T., Han S.H., Yang C.W., Kim N.H., Kim Y.S., Kang S.W., Kim Y.L., Yoo T.H. The Optimal Blood Pressure Target in Different Dialysis Populations. Sci Rep, 2018, vol. 8, no. 1, pp. 14123.
16. Vincenti F., Jensik S.C., Filo R.S., Miller J., Pirsch J. A long-term comparison of tacrolimus (FK506) and cyclosporine in kidney transplantation: Evidence for improved allograft survival at five years. Transplantation, 2002, vol. 73, no. 5, pp. 775–782.
17. Hwang S.Y., Hong Y.A., Oh S.Y., Seo J.H., Lee Y.M., Park S.W., Kim J.S., Wang J.K., Kim J.Y., Lee J.E., Ko G.J., Pyo H.J., Kwon Y.J. Optimal hemoglobin level for anemia treatment in a cohort of hemodialysis patients. Kidney Res Clin Pract, 2015, vol. 34, no. 1, pp. 20–27.
18. Klinicheskiy protokol diagnostiki i lecheniya pacientov (vzrosloe naselenie) s nefrologicheskimi zabolevaniyami pri okazanii medicinskoy pomosch’i v ambulatorny’h i stacionarny’h usloviyah rayonny’h, oblastny’h i respublikanskih organizaciy zdravoohraneniya Respubliki Belarus [elec tronic resource]: pril. 2 k prikazu M-va zdravoohraneniya Resp. Belarus’, 22 sent. 2011, № 920 [Clinical Protocol of diagnosis and treatment of patients (adults) with nephrological diseases in the provision of medical care in outpatient and inpatient settings of regional, regional and national health organizations of the Republic of Belarus]. Available at: ht tp://minzdrav.gov.by/. (accessed 2.10.2018). (in Russian).
19. KDOQI Clinical Practice Guideline and Clinical Practice Recommendations for anemia in chronic kidney disease: 2007 update of hemoglobin target. Am J Kidney Dis, 2007, vol. 50, no. 3, pp. 471–530.
20. Vatazin A.V., Zul’karnaev A.B., Kruglov E.E., Astahov P.V., Mirolyub K., Gubarev K.K., Vasilenko I.A., Ar temov D.V Profil’ interleykina- 6 v rannem posleoperacionnom periode posle transplantacii pochki [Interleukin- 6 profile in the early pos toperative period af ter kidney transplantation]. Vestn transplantologii i iskusstv organov, 2013, vol. 15, no. 1, pp. 51–59. (in Russian).

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