Ревматоидный артрит: современный взгляд на проблемные вопросы питания

Н.А. Мартусевич, Н.А. Павловская, Э.И. Кислач, Н.П. Митьковская

УО «Белорусский государственный медицинский университет», Минск, Беларусь

В статье рассматривается роль питания как дополнительного фактора в лечении ревматоидного артрита (далее – РА). Приведены данные фудомики о механизмах влияния питания на патогенез РА с позиции модуляции иммуновоспалительных процессов, изменения микробиоты кишечника, регуляции экспрессии генов, связанных с воспалением. Обобщены ключевые направления исследований – от отдельных нутриентов до комплексных диетических подходов; приведены научные данные о роли питательных веществ и напитков в снижении активности РА, а также представлены актуальные рекомендации международных ревматологических сообществ. Особое внимание уделено средиземноморской диете, имеющей наибольшую доказательную базу.

ключевые слова: диетотерапия, международные рекомендации, микроРНК, микробиота, нутриенты, ревматоидный артрит, фудомика

для цитирования: Н.А. Мартусевич, Н.А. Павловская, Э.И. Кислач, Н.П. Митьковская. Ревматоидный артрит: современный взгляд на проблемные вопросы питания. Неотложная кардиология и кардиоваскулярные риски, 2024, Т. 8, № 2, С. 2355–2365.

Rheumatoid arthritis: a modern look at problematic nutrition issues

N.A. Martusevich, N.A. Pavlovskaya, E.I. Kislach, N.P. Mitkovskaya

The article examines the role of nutrition as an additional factor in the treatent of rheumatoid arthritis (hereinafter – RA). Foodomics data on the mechanisms of nutrition influence on the pathogenesis of RA are presented from the perspective of modulation of immuno-inflammatory processes, changes in the intestinal microbiota, and regulation of gene expression associated with inflammation. The key areas of research are summarized – from individual nutrients to complex dietary approaches. Besides, we present scientific data on the role of nutrients and beverages in reducing RA activity, as well as current recommendations from international rheumatology communities. Special attention is paid to the Mediterranean diet, which has the greatest evidence base.

keywords: diet therapy, international recommendations, microRNAs, microbiota, nutrients, rheumatoid arthritis, foodomics

for references: N.A. Martusevich, N.A. Pavlovskaya, E.I. Kislach, N.P. Mitkovskaya. Rheumatoid arthritis: a modern look at problematic nutrition issues. Neotlozhnaya kardiologiya i kardiovaskulyarnye riski [Emergency cardiology and cardiovascular risks], 2024, vol. 8, no. 2, pp. 2355–2365.

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