А.В. Котович, А.П. Якимчук, И.А. Махановский, О.О. Руммо, А.М. Дзядзько, Л.В. Рачок
ГУ «Минский научно-практический центр хирургии, трансплантологии и гематологии», г. Минск, Республика Беларусь, УО «Белорусский государственный медицинский университет», г. Минск, Республика Беларусь
В данной статье представлены данные проведенного систематического обзора и мета-анализа по эффективности коэнзима Q10 в рамках преабилитации. Оценивались такие исходы как: уровень CK-MB, значение сердечного индекса (CI) через 24 часа после вмешательства, длительность госпитализации уровень hsTroponin и степень вазопрессорной поддержки через 24 часа после кардиохирургического вмешательства. Ввиду множества ограничений, проведенный мета-анализ не показал эффективности коэнзима Q10, что требует исследований надлежащего качества для более подробного изучения данного препарата.
ключевые слова: коэнзим Q10, кардиохирургия, мета-анализ, преабилитация
для цитирования: А.В. Котович, А.П. Якимчук, И.А. Махановский, О.О. Руммо, А.М. Дзядзько, Л.В. Рачок. Систематический обзор и мета-анализ эффективности применения коэнзима Q10 с целью профилактики послеоперационных осложнений при кардиохирургических вмешательствах. Неотложная кардиология и кардиоваскулярные риски, 2024, Т. 8, № 2, С. 2348–2354.
Systematic review and meta-analysis of the effectiveness of coenzyme Q10 for the prevention of postoperative complications during cardiac surgery
A.V. Kotovich, A.P. Yakimchuk, I.A. Makhanovsky, O.O. Rummo, A.M. Dzyadzko, L.V. Rachok
This article presents the data from a systematic review and meta-analysis of the effectiveness of coenzyme Q10 in the framework of preabilitation. The outcomes assessed included: CK-MB level, cardiac index (CI) value 24 hours after intervention, duration of hospitalization, hsTroponin level and degree of vasopressor support 24 hours after cardiac surgery. Due to many limitations, the meta-analysis has not shown the effectiveness of coenzyme Q10, which requires investigations of proper quality for a more detailed study of this drug.
keywords: coenzyme Q10, cardiac surgery, meta-analysis, rehabilitation
for references: AA.V. Kotovich, A.P. Yakimchuk, I.A. Makhanovsky, O.O. Rummo, A.M. Dzyadzko, L.V. Rachok. Systematic review and meta-analysis of the effectiveness of coenzyme Q10 for the prevention of postoperative complications during cardiac surgery. Neotlozhnaya kardiologiya i kardiovaskulyarnye riski [Emergency cardiology and cardiovascular risks], 2024, vol. 8, no. 2, pp. 2348–2354.
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