АССОЦИАЦИЯ ПОЛИМОРФИЗМА ГЕНОВ СИСТЕМЫ ГЕМОСТАЗА С КЛИНИКО-ЛАБОРАТОРНЫМИ ПОКАЗАТЕЛЯМИ У ПАЦИЕНТОВ С ИНФАРКТОМ МИОКАРДА
Т.С. Королева , А.Г. Булгак , И.Б. Моссэ , Н.Г. Седляр , О.В. Зотова
Государственное учреждение «Республиканский научно-практический центр «Кардиология», Минск, Беларусь, Государственное учреждение образования «Белорусская медицинская академия последипломного образования», Государственной научное учреждение «Институт генетики и цитологии Национальной академии наук Беларуси»
Оценена взаимосвязь полиморфных вариантов генов FGA, FGG, F2, F5, F11, F13, PAI-1 и GP6 с данными клинико-инструментальных и лабораторных исследований среди пациентов с инфарктом миокарда из Республики Беларусь. Показано, что для пациентов с инфарктом миокарда имеются статистически значимые ассоциации между полиморфными вариантами генов F11 (rs2289252 и rs2036914), F13 (rs5985), F5 (rs6025), PAI-1 (rs1799889), FGG (rs2066865) и рядом лабораторных значений и функциональных показателей миокарда. Совокупный анализ как генетической компоненты (полиморфизм ДНК), так и результатов
динамичного наблюдения пациента в стационаре, способен корректно оценить риски возникновения и нежелательного прогрессирования заболеваний, включая инфаркт миокарда.
ключевые слова: инфаркт миокарда, полиморфизм, лабораторные исследования, функциональные показатели миокарда, ассоциация.
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