Остеосаркопения и артериальная гипертензия: современный взгляд на проблему

К.Ю. Антюх, Е.А. Григоренко, А.Ф. Шептулина, О.М. Драпкина, Н.П. Митьковская
Республиканский научно-практический центр «Кардиология», Минск, Беларусь, Белорусский государственный медицинский университет, Минск, Беларусь, Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр терапии и профилактической медицины» Министерства здравоохранения Российской Федерации, Москва, Россия, Федеральное государственное бюджетное образовательное учреждение высшего образования «Московский государственный медико-стоматологический университет, имени А.И. Евдокимова» Министерства здравоохранения Российской Федерации, Москва, Россия
О стеосаркопения характеризуется сочетанием низкой мышечной массы (саркопении) и сниженной минеральной плотности костной ткани (остеопении/остеопороза). Результаты научных исследований, проведенных в последние годы, свидетельствуют о наличии взаимосвязи между артериальной гипертензией, нарушениями метаболизма костной ткани и/или саркопенией. В частности, известно, что в развитии и прогрессировании как артериальной гипертензии, так и саркопении принимают участие системное воспаление, оксидативный стресс, инсулинорезистентность. Те же факторы могут играть роль в патогенезе остеопении и остеопороза, а патологические механизмы, лежащие в основе повышения артериального давления, как показано в экспериментальных и клинических исследованиях, способны дополнительно влиять на снижение минеральной плотности костной ткани. В данном обзоре изложены современные представления о диагностике, эпидемиологии, этиологии, а также возможных механизмах патогенеза остеосаркопении у пациентов с артериальной гипертензией.
ключевые слова: саркопения, остеопороз, артериальная гипертензия, миокины, скелетные мышцы.

для цитирования: К.Ю. Антюх, Е.А. Григоренко, А.Ф. Шептулина, О.М. Драпкина, Н.П. Митьковская. Остеосаркопения и артериальная гипертензия: современный взгляд на проблему. Неотложная кардиология и кардиоваскулярные риски, 2023, Т. 7, № 1, С. 1868–1875.

Osteosarcopenia and arterial hypertension: current approaches to the problem
K. Antyukh, E. Grigorenko, А. Sheptulina, O. Drapkina, N. Mitkovskaya
O steosarcopenia is characterized by a combination of low muscle mass (sarcopenia) and reduced bone mineral density (osteopenia/osteoporosis). The results of scientific studies conducted in recent years indicate the existence of a relationship between arterial hypertension, disorders of bone metabolism and / or sarcopenia. In particular, it is known that systemic inflammation, oxidative stress, and insulin resistance are involved in the development and progression of both arterial hypertension and sarcopenia. The same factors may play a role in the pathogenesis of osteopenia and osteoporosis, and the pathological mechanisms underlying the increase in blood pressure, as shown in experimental and clinical studies, can additionally influence the decrease in bone mineral density. This review outlines the current understanding of the diagnosis, epidemiology, etiology, and possible mechanisms of the pathogenesis of osteosarcopenia in patients with arterial hypertension.
keywords: sarcopenia, osteoporosis, arterial hypertension, myokines, skeletal muscle.

for references: K. Antyukh, E. Grigorenko, А. Sheptulina, O. Drapkina, N. Mitkovskaya. Osteosarcopenia and arterial hypertension: current approaches to the problem. Neotlozhnaya kardiologiya i kardiovaskulyarnye riski [Emergency cardiology and cardiovascular risks], 2023, vol. 7, no. 1, pp. 1868–1875.

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