Независимые предикторы и прогнозирование инфаркта миокарда в отдаленном периоде у пациентов с нестабильной стенокардией после стентирования коронарных артерий

Е.А. Медведева, Л.Г. Гелис, О.Л. Полонецкий, И.И. Русских
ГУ Республиканский научно-практический центр «Кардиология», Минск
Цель: разработать независимые предикторы для прогнозирования инфаркта миокарда в отдаленном периоде у пациентов с нестабильной стенокардией после стентирования коронарных артерий по результатам семилетнего наблюдения. Материалы и методы. За период 2014 г. – 2015 г. в исследование включено 165 пациентов с нестабильной стенокардией и стентированием коронарных артерий. Стентирование выполнялось на 3,2±1,6 сутки от поступления в стационар, использовались стенты с лекарственным покрытием, среднее количество стентов – 2,1±0,78 на человека. Всем пациентам выполнялось определение уровня тропонина I, миелопероксидазы, С-реактивного белка; проводилась оценка коагуляционного гемостаза, выполнение теста генерации тромбина, агрегатограмма. Пациентам выполнялась эхокардиография, коронароангиография. Двойная антитромботическая терапия назначалась на 12 месяцев. Срок наблюдения составил 7,0±1,6 года.
ключевые слова: нестабильная стенокардия, стентирование коронарных артерий, гемостаз, инфаркт миокарда

для цитирования: Е.А. Медведева, Л.Г. Гелис, О.Л. Полонецкий, И.И. Русских. Независимые предикторы и прогнозирование инфаркта миокарда в отдаленном периоде у пациентов с нестабильной стенокардией после стентирования коронарных артерий. Неотложная кардиология и кардиоваскулярные риски, 2021, Т. 5, № 1, С. 1109–1120.

Independent predictors and prognosis of long-term myocardial infarction in patients with unstable angina after coronary artery stenting
Miadzvedzeva Alena, Gelis Ludmila, Polonetsky Oleg, Russkikh Iryna
Objective. to develop independent predictors for predicting long-term myocardial infarction (MI) in patients (pts) with unstable angina (UA) after coronary artery stenting (PCI) based on the results of a seven-year follow-up. Materials and Methods. The study involved 165 pts with UA and coronary artery stenting (PCI). PCI was performed in 3.2±1.6 days after admission to the in-patient department. Drug-coated stents (Xience V and Biomatrix) were used, the average number of stents was 2.1±0.8 per person, the average length of the stented area was 43.12±25.6 mm, and the average diameter of the implanted stents was 3.12±0.5 mm. All patients were assessed for troponin I, myeloperoxidase, and C-reactive protein levels; coagulation hemostasis was assessed; and a thrombin generation test was performed. The aggregatogram was performed on the analyzer Multiplate (ASPI-test, ADP-test). The patients underwent echocardiography, coronary angiography. Double antithrombotic therapy with clopidogrel 75 mg and acetylsalicylic acid 75 mg was prescribed for 12 months. The follow-up period was 7.0±1.6 years.
keywords: unstable angina, coronary artery stenting, hemostasis, myocardial infarction

for references: Miadzvedzeva Alena, Gelis Ludmila, Polonetsky Oleg, Russkikh Iryna. Independent predictors and prognosis of long-term myocardial infarction in patients with unstable angina after coronary artery stenting. Neotlozhnaya kardiologiya i kardiovaskulyarnye riski [Emergency cardiology and cardiovascular risks], 2021, vol. 5, no. 1, pp. 1109–1120.

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